An engineered model of metastatic colonization of human bone marrow reveals breast cancer cell remodeling of the hematopoietic niche
Proceedings of the National Academy of Sciences,
Год журнала:
2024,
Номер
121(42)
Опубликована: Окт. 7, 2024
Incomplete
understanding
of
metastatic
disease
mechanisms
continues
to
hinder
effective
treatment
cancer.
Despite
remarkable
advancements
toward
the
identification
druggable
targets,
options
for
patients
in
remission
following
primary
tumor
resection
remain
limited.
Bioengineered
human
tissue
models
sites
capable
recreating
physiologically
relevant
milieu
colonization
may
strengthen
our
grasp
cancer
progression
and
contribute
development
therapeutic
strategies.
We
report
use
an
engineered
model
bone
marrow
(eBM)
identify
microenvironmental
cues
regulating
cell
proliferation
investigate
how
triple-negative
breast
(TNBC)
lines
influence
hematopoiesis.
Notably,
individual
stromal
components
niche
(osteoblasts,
endothelial
cells,
mesenchymal
stem/stromal
cells)
were
each
critical
quiescence
three-dimensional
eBM
niche.
found
that
hematopoietic
stem
progenitor
cells
(HSPCs)
impacted
TNBC
growth
responded
presence
with
a
shift
HSPCs
(CD34
+
CD38
−
)
downstream
myeloid
lineages
(CD11b
CD14
).
To
account
heterogeneity
show
proof-of-concept
ability
patient-specific
studies,
we
demonstrate
patient-derived
organoids
survive
proliferate
eBM,
resulting
distinct
shifts
myelopoiesis
are
similar
those
observed
aggressively
lines.
envision
this
will
facilitate
studies
niche-specific
individualized
responses
treatment.
Язык: Английский
Regulation of metastatic organotropism
Trends in cancer,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 1, 2024
Язык: Английский
Symptomatic bone marrow metastasis in triple-negative breast cancer: a case report and literature review
Frontiers in Oncology,
Год журнала:
2025,
Номер
15
Опубликована: Март 28, 2025
Bone
metastasis
is
common
in
breast
cancer,
but
symptomatic
bone
marrow
involvement
exceedingly
rare.
This
report
presents
a
case
of
young
female
patient
with
triple-negative
cancer
(TNBC)
initially
presenting
metastasis.
Upon
admission,
blood
tests
revealed
severe
thrombocytopenia.
biopsy
confirmed
tumor
cell
infiltration,
and
immunohistochemistry
identified
metastatic
cells.
The
received
paclitaxel
eribulin
chemotherapy
combined
transfusion
support,
achieving
significant
symptom
control.
rare
highlights
the
importance
early
detection
aggressive
management
TNBC
Язык: Английский
A novel perspective on bone tumors: advances in organoid research
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 8, 2025
Bone
tumor
organoids
are
three-dimensional
cell
culture
models
derived
from
patient
tissues
or
cells,
capable
of
highly
replicating
the
growth
patterns
and
interactions
bone
tumors
in
vitro
.
Current
treatments
for
hindered
by
challenges
such
as
drug
resistance,
recurrence,
metastasis.
Organoids
enhance
physiological
relevance
models,
thereby
improving
treatment
precision
overcoming
limitations
current
therapeutic
approaches.
Organoid
technology
has
made
preliminary
applications
research,
including
primary
tumors,
metastatic
marrow-derived
tumors.
This
review
will
explore
establishment
organoids,
summarize
their
prospects
various
diseases,
discuss
integration
with
emerging
technologies.
Additionally,
future
directions
organoid
research
be
discussed.
In
future,
expected
to
promote
further
development
medicine.
Язык: Английский