Dynamics of primary cilia in endothelial and mesenchymal cells throughout mouse lung development

Developmental Dynamics, Год журнала: 2025, Номер unknown

Опубликована: Март 8, 2025

Cilia are specialized structures found on a variety of mammalian cells, with variable roles in the transduction mechanical and biological signals (by primary cilia, PC), as well generation fluid flow motile cilia). Their critical role establishment left-right axis early development is described, defense immune function multiciliated upper airway epithelium. By contrast, detailed analysis ciliary status specific cell types during organogenesis postnatal has received less attention. In this study, we investigate progression within endothelium mesenchyme lung. Remarkably, find that pulmonary endothelial cells (ECs) lack PC at all stages development, except low numbers proximal portions older arteries. Mesenchymal by widely exhibit large subset PDGFRα+ fibroblasts maintain into adulthood. The dynamic differential ciliation multiple cellular populations developing lung both challenges prior assertions highlights need to understand their spatiotemporal functions.

Язык: Английский

Phosphorylation at the Helm: Kinase‐Mediated Regulation of Primary Cilia Assembly and Disassembly

Cytoskeleton, Год журнала: 2025, Номер unknown

Опубликована: Март 10, 2025

The primary cilium serves as an antenna of most vertebrate cells and is important for conveying cues from several signaling pathways into appropriate cellular responses during development homeostasis. Cilia assembly disassembly processes are thought to be strictly controlled; however, the precise nature molecular events underlying this control still awaits full resolution. Through their enzymatic activity, kinases function flexible yet highly controllable regulators a vast variety processes. Their activity ranges cell cycle regulation motility, signal transduction, metabolism. This review focuses on emerging role in cilia biology. We underscore functions formation, maintenance, resorption while examining available models respective mechanisms actions.

Язык: Английский

Comprehensive mapping of primary cilia dynamics throughout mouse development and aging

Science Bulletin, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский