Integrative systems biology framework discovers common gene regulatory signatures in mechanistically distinct inflammatory skin diseases
npj Systems Biology and Applications,
Год журнала:
2025,
Номер
11(1)
Опубликована: Фев. 27, 2025
More
than
20%
of
the
population
across
world
is
affected
by
non-communicable
inflammatory
skin
diseases
including
psoriasis,
atopic
dermatitis,
hidradenitis
suppurativa,
rosacea,
etc.
Many
these
chronic
are
painful
and
debilitating
with
limited
effective
therapeutic
interventions.
This
study
aims
to
identify
common
regulatory
pathways
master
regulators
that
regulate
molecular
pathogenesis
diseases.
We
designed
an
integrative
systems
biology
framework
significant
several
Network
analytics
unraveled
55
high-value
proteins
as
in
which
can
serve
putative
drug
targets
for
more
treatments.
identified
IKZF1
a
shared
regulator
rosacea
known
disease-derived
molecules
developing
efficacious
combinatorial
treatments
The
proposed
very
modular
indicates
path
mechanism-based
development
from
complex
transcriptomics
data
other
multi-omics
data.
Язык: Английский
Single-cell transcriptome integrated with genome-wide association study reveals heterogeneity of carotid and femoral plaques and its association with plaque stability
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Апрель 7, 2025
Carotid
and
femoral
plaques
exhibit
varying
degrees
of
stability;
however,
the
relationships
different
genes/cell
types
with
plaque
embolism
are
poorly
understood.
We
evaluated
differential
gene/cell
expression
investigated
cells/genes
associated
carotid
artery
embolism.
sc-RNA-seq
bulk
RNA
data
were
obtained
to
identify
differentially
expressed
genes
(DEGs).
Seven
machine
learning
models
trained,
top
10
DEGs
across
all
selected.
The
most
disturbed
cells
in
identified
using
Augur,
while
analyzed
through
scPagwas.
differences
embolism-related
further
analyzed.
Compared
plaques,
had
80
downregulated
90
upregulated
genes.
Machine
key
between
predominantly
from
HOX
gene
family.
Natural
Killer
(NK)
significantly
they
may
be
strongly
Among
NK
cells,
CD2
was
Our
research
offer
new
insights
into
atherosclerosis
at
locations.
Язык: Английский
Evaluation of the influenza vaccine protection in the house dust mite-induced chronic allergic asthma mice model and the evaluation of squalene oil in water emulsion as an adjuvant candidate
Respiratory Research,
Год журнала:
2025,
Номер
26(1)
Опубликована: Апрель 9, 2025
Язык: Английский
Hidradenitis Suppurativa Preclinical Studies: Models and Results
Experimental Dermatology,
Год журнала:
2025,
Номер
34(S1)
Опубликована: Март 1, 2025
ABSTRACT
Hidradenitis
suppurativa
is
a
solely
human
disease
for
which—unlike
other
inflammatory
dermatoses—applied
animal
models
are
not
available.
In
order
to
study
skin
cell
immunology
under
conditions
which
approximate
the
in
vivo
functions,
maintenance
of
structural
tissue
integrity
experimental
essential.
Consequently,
several
ex
using
lesional,
perilesional
hidradenitis
and
control
healthy
skin,
have
been
described,
claim
represent
fast
relatively
simple
methods
investigate
pathophysiology
preclinically
detect
effectiveness
candidate
therapeutic
agents.
At
least
some
these
seem
situation
by
maintaining
patients'
architecture
days
expressing
biomarkers
also
detected
vivo.
Validation
still
remains
be
performed
majority
evaluating
efficacy
drugs,
introduced
clinical
studies
and/or
approved
HS
treatment.
Язык: Английский