ZFT is the major iron and zinc transporter inToxoplasma gondii

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Апрель 17, 2025

Abstract Transition metals, such as iron and zinc, are indispensable trace elements for eukaryotic life, acting co-factors in essential processes ranging from respiration metabolism to DNA replication. These metals can be transported into cells by an evolutionary-conserved family of metal transporters; however, how the ubiquitous mammalian parasite Toxoplasma gondii acquired has been unknown. Here, we have identified characterised first zinc importer T. . This transporter, named ZFT, localised plasma membrane is parasite’s life cycle. We find ZFT regulated availability overexpression sensitises excess zinc. Using a conditional knockdown system, that leads reduction mitochondrial switch more quiescent lifecycle stage. To confirm transport activity, parasite-associated iron, complements loss transporter activity yeast model. Overall, uptake demonstrated importance cell. finding reveals critical piece puzzle understanding this obligate intracellular thrives within its host.

Язык: Английский

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Iron gatekeeper in malaria

Nature Reviews Microbiology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 19, 2024

Язык: Английский

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