Gut-to-brain regulation of Drosophila aging through neuropeptide F, insulin, and juvenile hormone
Proceedings of the National Academy of Sciences,
Год журнала:
2024,
Номер
121(43)
Опубликована: Окт. 16, 2024
Dietary
restriction
(DR)
slows
aging
in
many
animals,
while
some
cases,
the
sensory
signals
from
diet
alone
are
sufficient
to
retard
or
accelerate
lifespan.
The
digestive
tract
is
a
candidate
location
sense
nutrients,
where
neuropeptides
secreted
by
enteroendocrine
cells
(EEC)
produce
systemic
response
food.
Here,
we
measure
how
Drosophila
neuropeptide
F
(NPF)
into
adult
circulation
EEC
and
find
that
specific
differentially
respond
dietary
sugar
yeast.
Female
lifespan
increased
when
gut
NPF
genetically
depleted,
this
manipulation
blunt
longevity
benefit
conferred
DR.
Depletion
of
receptors
at
insulin-producing
neurons
brain
also
increases
female
lifespan,
consistent
with
observations
loss
decreases
neuronal
insulin
secretion.
repressing
reversed
treating
adults
juvenile
hormone
(JH)
analog.
JH
produced
corpora
allata,
inhibition
receptor
tissue
titer
extends
both
males
females,
restored
wild
type
Overall,
modulate
through
interorgan
communication
mediated
gut–brain–corpora
allata
axis,
impacts
its
control
titer.
These
data
suggest
consider
human
incretins
their
analogs,
which
used
treat
obesity
diabetes,
may
impact
aging.
Язык: Английский
Perception and Longevity Control in Invertebrate Model Organisms—A Mini-Review of Recent Advances
Biomolecules,
Год журнала:
2025,
Номер
15(2), С. 187 - 187
Опубликована: Янв. 28, 2025
Perception
alone
can,
in
some
cases,
be
sufficient
to
modulate
aging
and
longevity.
These
influences
on
are
perhaps
mediated
by
changes
motivational
states
that
regulate
metabolism
physiology
impact
health.
Simple
invertebrate
models
uniquely
enable
detailed
dissection
of
integrative
pathways
linking
perceptions
remain
the
leading
systems
for
advancing
this
field.
Over
past
25
years,
studies
using
fruit
fly
Drosophila
melanogaster
nematode
Caenorhabditis
elegans
have
demonstrated
sensory
cues,
such
as
those
related
food
or
mating,
can
influence
independently
physical
acts
associated
with
them.
In
review,
we
highlight
recent
advancements
these
models,
focusing
two
key
areas
progress:
(i)
discovery
lifespan
modulation
driven
novel
cues
across
multiple
modalities,
including
non-sexual
social
experience,
light,
dietary
choices;
(ii)
assignment
new
aging-regulation
functions
specific
neurons
downstream
perception.
The
latter
offers
an
exciting
first
glimpse
at
neuronal
circuits
integrating
states,
physiology,
aging.
Язык: Английский
A gut hormone governing protein appetite and longevity
Nature Metabolism,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 14, 2025
Язык: Английский
Duplicated paralog of insulin receptor functions distinctively in locust reproduction for high fecundity
Insect Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 25, 2025
Abstract
Insulin
receptor
(InR)
mediates
the
highly
conserved
insulin/insulin‐like
growth
factor
signaling
pathway
that
regulates
a
broad
range
of
life‐history
traits.
Most
insects
encode
2
InR
paralogs,
but
their
functional
divergence
and
redundancy
remain
to
be
explored.
Here,
we
pursued
functionality
InRs,
LmInR1,
LmInR2,
in
migratory
locust
Locusta
migratoria
.
LmInR1
is
clustered
into
clade
ancestral
,
LmInR2
belongs
gene
duplication.
While
expression
was
at
highest
levels
nymphal
stage
adult
ovary,
predominantly
expressed
fat
body.
Loss
function
led
defective
nymph‐adult
transition
reproduction.
depletion
had
little
effect
on
metamorphosis,
caused
severe
defects
female
reproduction,
including
remarkable
reduction
Vitellogenin
(
Vg
)
arrested
egg
development.
Interestingly,
responded
lower
glucose,
whereas
response
increasing
concentrations
glucose.
Moreover,
not
responsive
juvenile
hormone
(JH)
its
receptor.
The
results
suggest
has
evolved
neofunctionalization
for
massive
synthesis
required
synchronous
maturation
dozens
oocytes
high‐fecundity
insect.
This
study
reveals
novel
aspect
differential
functions
paralogs
provides
new
insights
understanding
insulin
cascade
insects.
Язык: Английский
Sleep timing in flies from “adolescence” to adulthood
Fly,
Год журнала:
2024,
Номер
19(1)
Опубликована: Дек. 30, 2024
The
aim
of
the
present
study
was
to
assess
sleep
timing
in
Drosophila
melanogaster
at
different
ages,
within
setting
an
enforced
schedule
varying
light-dark
stimuli,
simulating
light
exposure
variations
between
four
typical
office
working
days
and
one
free
day
spent
outside
by
a
human,
for
total
30
days.
Locomotor
activity
recording
started
when
male
flies
were
3
old.
Flies
exhibited
bimodal
pattern,
with
morning
evening
peak,
clear
anticipation
lights
on
off
transitions.
From
experimental
10
(i.e.
12-day-old
flies)
onwards,
decrease
counts/increase
amount
observed.
On
days,
rise
counts
reduction
during
interval
observed
also
present,
albeit
less
obvious,
subsequent
interval.
A
progressive
delay
onset
first
experiment,
peaking
4
6-day-old
flies),
after
which
gradually
advanced.
offset
13
stabilized.
In
conclusion,
'adolescent'
changes
that
reminiscent
those
human
adolescents.
Язык: Английский