Bimetallic Plasmonic Nanozyme‐Based Microneedle for Synergistic Ferroptosis Therapy of Melanoma DOI Creative Commons
Wei Duan, Keying Xu, Yue Gao

и другие.

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Май 19, 2025

Abstract Melanoma is the most common malignant skin tumor, characterized by complexity, invasiveness, and heterogeneity. Conventional therapies often yield poor outcomes, posing significant clinical challenges. Here, a microneedle (MN) patch that integrates nanozyme traditional Chinese medicine (TCM) for ferroptosis pathway‐dependent combined therapy of melanoma designed. To amplify therapeutic activity, novel Au@MoS 2 bimetallic plasmonic (BPNzyme) prepared through simple aqueous synthesis strategy involving two‐step process. Owing to synergy between heterostructures, this rationally designed BPNzyme exhibits significantly enhanced characteristics, including near‐infrared (NIR) photothermal effect, peroxidase‐like glutathione property, which can effectively reshape tumor microenvironment disrupt redox homeostasis. Under action TCM β‐elemene (β‐ELE) NIR light, further enhancement oxidative damage, lipid peroxidation, peroxidase 4 expression downregulation are observed cells, validating synergistic amplification ferroptosis. Moreover, transdermal delivery β‐ELE using soluble hyaluronic acid MN achieves 99.8% growth suppression without systemic toxicity in vivo. These findings highlight potential BPNzyme‐based system as promising innovative non‐invasive, efficient, safe combination melanoma.

Язык: Английский

Bimetallic Plasmonic Nanozyme‐Based Microneedle for Synergistic Ferroptosis Therapy of Melanoma DOI Creative Commons
Wei Duan, Keying Xu, Yue Gao

и другие.

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Май 19, 2025

Abstract Melanoma is the most common malignant skin tumor, characterized by complexity, invasiveness, and heterogeneity. Conventional therapies often yield poor outcomes, posing significant clinical challenges. Here, a microneedle (MN) patch that integrates nanozyme traditional Chinese medicine (TCM) for ferroptosis pathway‐dependent combined therapy of melanoma designed. To amplify therapeutic activity, novel Au@MoS 2 bimetallic plasmonic (BPNzyme) prepared through simple aqueous synthesis strategy involving two‐step process. Owing to synergy between heterostructures, this rationally designed BPNzyme exhibits significantly enhanced characteristics, including near‐infrared (NIR) photothermal effect, peroxidase‐like glutathione property, which can effectively reshape tumor microenvironment disrupt redox homeostasis. Under action TCM β‐elemene (β‐ELE) NIR light, further enhancement oxidative damage, lipid peroxidation, peroxidase 4 expression downregulation are observed cells, validating synergistic amplification ferroptosis. Moreover, transdermal delivery β‐ELE using soluble hyaluronic acid MN achieves 99.8% growth suppression without systemic toxicity in vivo. These findings highlight potential BPNzyme‐based system as promising innovative non‐invasive, efficient, safe combination melanoma.

Язык: Английский

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