Nested likelihood-ratio testing of the nonsynonymous:synonymous ratio suggests greater adaptation in the piRNA machinery of Drosophila melanogaster compared with Drosophila ananassae and Drosophila willistoni, two species with higher repeat content

G3 Genes Genomes Genetics, Год журнала: 2025, Номер unknown

Опубликована: Фев. 21, 2025

Abstract Numerous studies have revealed a signature of strong adaptive evolution in the piwi-interacting RNA (piRNA) machinery Drosophila melanogaster, but cause this pattern is not understood. Several hypotheses been proposed. One hypothesis that transposable element (TE) families and piRNA are co-evolving under an evolutionary arms race, perhaps due to antagonism by TEs against machinery. A related, though co-evolutionary, recurrent TE invasion drives adapt novel strategies. third ongoing fluctuation abundance leads adaptation must constantly adjust between sensitivity for detecting new elements specificity avoid cost off-target gene silencing. Rapid may also be driven independently TEs, instead from other functions such as role piRNAs suppressing sex-chromosome meiotic drive. We sought evaluate impact on D. melanogaster 2 species with higher repeat content—Drosophila ananassae willistoni. This comparison was achieved employing likelihood-based testing framework based McDonald–Kreitman test. show we can reject faster rate these species. propose high either recent influx occurred during range expansion or selection

Язык: Английский

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The ever-diversifying landscape of intra-genomic conflict

Seminars in Cell and Developmental Biology, Год журнала: 2025, Номер 169, С. 103603 - 103603

Опубликована: Март 27, 2025

Язык: Английский

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An innovation in host responses to escalating genomic conflicts

Trends in Genetics, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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