International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(6), С. 3512 - 3512
Опубликована: Март 20, 2024
Soybean
phytophthora
blight
is
a
severe
menace
to
global
agriculture,
causing
annual
losses
surpassing
USD
1
billion.
Present
crop
loss
mitigation
strategies
primarily
rely
on
chemical
pesticides
and
disease-resistant
breeding,
frequently
surpassed
by
the
pathogens'
quick
adaptive
evolution.
In
this
urgent
scenario,
our
research
delves
into
innovative
antimicrobial
peptides
characterized
low
drug
resistance
environmental
friendliness.
Inhibiting
chitin
synthase
gene
activity
in
Phytophthora
sojae
impairs
vital
functions
such
as
growth
sporulation,
presenting
an
effective
method
reduce
its
pathogenic
impact.
study,
we
screened
16
previously
tested
evaluate
their
effects
against
using
structure-guided
design,
which
involves
molecular
docking,
saturation
mutagenesis,
dynamics,
toxicity
prediction.
The
silico
analysis
identified
AMP_04
with
potential
inhibitory
sojae's
synthase.
Through
three
rounds
of
pin-pointed
most
triple
mutant,
TP
(D10K,
G11I,
S14L).
Molecular
dynamic
simulations
revealed
TP's
stability
synthase-TP
complex
transmembrane
mechanism,
employing
all-atom
force
field.
Our
findings
demonstrate
efficacy
occupying
substrate-binding
pocket
translocation
catalytic
channel.
Effective
inhibition
enzyme
can
be
achieved.
Specifically,
mutant
demonstrates
enhanced
potency
decreased
relative
wild-type
AMP_04,
utilizing
mechanism
akin
barrel-stave
model
during
membrane
translocation.
Collectively,
study
provides
new
strategy
that
could
used
potent
agent
combatting
soybean
blight,
contributing
sustainable
agricultural
practices.
New Zealand Journal of Agricultural Research,
Год журнала:
2024,
Номер
unknown, С. 1 - 10
Опубликована: Янв. 24, 2024
Science
ensures
that
explanations
and
predictions
about
the
biological
physical
worlds
are
verifiable,
while
also
providing
an
approach
enables
improved
understanding
to
develop
be
permanently
recorded.
There
several
terms
in
common
usage
describe
approaches
used
scientific
research,
but
at
extremes,
words
such
as
‘reductionism’
‘holism’
now
frequently
encountered.
While
singular
reductionism
can
result
key
relationships
linkages
being
missed,
holism
appears
ignore
need
identify
how
confounding
factors
affect
quality
of
derived
from
complex
systems.
Here
we
suggest
science
is
not
a
simple
dichotomy
versus
holism.
Instead,
it
comprises
more
fluid
mission.
However,
within
multidisciplinary
agricultural
horticultural
one
regularly
finds
like
‘systems’,
‘integration’,
‘unifying’.
Reductionist
certainly
part
pursuit
holistic
solutions
problems,
least
transdisciplinary
research.
New Zealand Journal of Agricultural Research,
Год журнала:
2024,
Номер
unknown, С. 1 - 44
Опубликована: Ноя. 24, 2024
Pasture
productivity
gains
are
critical
for
maintaining
global
competitiveness
of
New
Zealand's
$38
billion
p.a.
animal
product
export
industries.
This
review
reveals
that
in
pasture
eaten
on
dairy
farms
declined
sharply
after
∼
2001/02,
from
+1.48%
yr−1
to
+0.26%
despite
continued
increases
nitrogen
(N)
fertiliser
use,
stocking
rate,
irrigation,
atmospheric
carbon
dioxide
(CO2)
concentrations
and
products
plant
breeding
programmes.
Thus,
(outputs
relative
inputs)
have
also
declined.
Almost
all
the
increase
since
1990
can
be
explained
by
N
rate.
Many
may
reached
peak
yields
possible
within
climatic
environment
late
twentieth
century.
Meanwhile,
climate
change
northern
regions
is
placing
downward
pressure
growth
persistence.
Climate
emerges
as
a
key
cause
declining
production
sheep/beef
some
regions,
while
elsewhere
predicted
under
warming
elevated
CO2
not
materialised.
There
major
strategic
knowledge
gap
regarding
state
resilience
national
resource
which
potentially
constrains
optimal
allocation
scarce
research
resources
issues
affecting
future
financial
environmental
sustainability.
IntechOpen eBooks,
Год журнала:
2024,
Номер
unknown
Опубликована: Фев. 21, 2024
Amidst
a
period
characterised
by
swift
technological
progress,
risk
management
encounters
unparalleled
obstacles
and
prospects.
The
many
facets
of
this
paradigm
change
are
examined
in
paper.
Conventional
assessment
techniques
need
to
as
businesses
revolutionised
technologies
like
blockchain,
IoT,
artificial
intelligence.
Even
though
these
advances
increase
production
efficiency,
they
also
bring
new
vulnerabilities,
which
means
profiles
be
reevaluated.
Furthermore,
cascading
risks
made
more
likely
the
growing
interconnection
global
systems.
Cybersecurity
becomes
critical,
necessitating
advanced
precautions
protect
private
data.
Moreover,
instruments
for
prediction
mitigation
possible
combination
machine
learning
predictive
analytics.
ethical
implications
automated
decision-making,
on
other
hand,
necessitate
careful
examination.
Organisations
must
promote
adaptability
volatile
terrain
fostering
culture
constant
innovation.
Navigating
difficulties
effectively
will
define
an
enterprise’s
resilience
durability
digitally
driven
future.
This
chapter
explores
era
advancements
how
those
could
mitigated.
methodology
employed
was
secondary
sources,
gathered
data
evaluated
using
text
content
generate
key
insights.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(6), С. 3512 - 3512
Опубликована: Март 20, 2024
Soybean
phytophthora
blight
is
a
severe
menace
to
global
agriculture,
causing
annual
losses
surpassing
USD
1
billion.
Present
crop
loss
mitigation
strategies
primarily
rely
on
chemical
pesticides
and
disease-resistant
breeding,
frequently
surpassed
by
the
pathogens'
quick
adaptive
evolution.
In
this
urgent
scenario,
our
research
delves
into
innovative
antimicrobial
peptides
characterized
low
drug
resistance
environmental
friendliness.
Inhibiting
chitin
synthase
gene
activity
in
Phytophthora
sojae
impairs
vital
functions
such
as
growth
sporulation,
presenting
an
effective
method
reduce
its
pathogenic
impact.
study,
we
screened
16
previously
tested
evaluate
their
effects
against
using
structure-guided
design,
which
involves
molecular
docking,
saturation
mutagenesis,
dynamics,
toxicity
prediction.
The
silico
analysis
identified
AMP_04
with
potential
inhibitory
sojae's
synthase.
Through
three
rounds
of
pin-pointed
most
triple
mutant,
TP
(D10K,
G11I,
S14L).
Molecular
dynamic
simulations
revealed
TP's
stability
synthase-TP
complex
transmembrane
mechanism,
employing
all-atom
force
field.
Our
findings
demonstrate
efficacy
occupying
substrate-binding
pocket
translocation
catalytic
channel.
Effective
inhibition
enzyme
can
be
achieved.
Specifically,
mutant
demonstrates
enhanced
potency
decreased
relative
wild-type
AMP_04,
utilizing
mechanism
akin
barrel-stave
model
during
membrane
translocation.
Collectively,
study
provides
new
strategy
that
could
used
potent
agent
combatting
soybean
blight,
contributing
sustainable
agricultural
practices.