Progress in Biophysics and Molecular Biology, Год журнала: 2024, Номер unknown
Опубликована: Дек. 1, 2024
Язык: Английский
Functional & Integrative Genomics, Год журнала: 2025, Номер 25(1)
Опубликована: Фев. 6, 2025
Abstract Long non-coding RNAs (lncRNAs) have emerged as essential regulators of gene expression, significantly influencing various biological processes. Approximately half all lncRNAs are classified long intergenic (lincRNAs), which situated among coding genes. Recent studies documented the role lincRNAs in pathogenesis lung diseases, including cancer, pulmonary fibrosis, and arterial hypertension. These can modulate expression through mechanisms, epigenetic modifications, transcriptional regulation, post-transcriptional regulation. By functioning competing endogenous (ceRNAs), affect activity microRNAs (miRNAs) their corresponding target This review delves into intricate mechanisms by contribute to development progression diseases. Furthermore, it discusses potential therapeutic targets.
Язык: Английский
Процитировано
1
Indus journal of bioscience research., Год журнала: 2025, Номер 3(1), С. 325 - 336
Опубликована: Янв. 16, 2025
Nanoparticles have become a transforming platform in drug delivery systems. Their remarkable advancement over traditional methods builds upon an improvement bioavailability, stability, and controlled of therapeutic agents. Here, we discuss the broad spectrum potential nanoparticle-based Challenges, innovations, surface modification strategies that affect their clinical translation are discussed. Notwithstanding they present, challenges including biocompatibility, toxicity, targeting efficiency persist restricting extensive utilization. The review emphasizes recent advancements, stimuli-responsive nanoparticles, which provide release reaction to environmental triggers, as well targeted delivery, facilitates selective accumulation agents at designated sites disease. Besides, techniques, such PEGylation, ligand conjugation, charge modulation, been highly promising improving stability reducing immunogenicity, enhancing cellular uptake. future systems based on nanoparticles will address these through new innovations nanoparticle design effect more effective treatments. While research advances, likely bring revolution personalized medicine, tailoring medical therapy for different diseases with minimal side effects better patient outcomes.
Язык: Английский
Процитировано
0
BMC Cancer, Год журнала: 2025, Номер 25(1)
Опубликована: Фев. 19, 2025
To explore the potential of serum exosomal miRNAs as novel biomarkers for pancreatic ductal adenocarcinoma (PDAC). Serum were screened and verified by microarray analysis quantitative real-time PCR (qRT-PCR) in patients with PDAC healthy controls. The correlation between clinical characteristics candidate was analyzed, diagnostic performance evaluated. miR-7977 miR-451a significantly upregulated compared controls, levels exosomes closely associated stage metastasis patients. area under curve (AUC) values 0.825 0.804 training set 0.796 0.830 validation set, respectively. A biomarker panel consisting these two resulted a power an AUC 0.901 0.918 set. might be PDAC. These miRNAs, when combined, exhibit optimal performance.
Язык: Английский
Процитировано
0
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Фев. 24, 2025
Metformin, widely used for the treatment of type 2 diabetes, has recently gained attention its potential anticancer properties. Several studies have shown that metformin inhibits cell viability in colon adenocarcinoma (COAD); however, research related to tumor-node-metastasis (TNM) stage is limited. As COAD frequently diagnosed at an advanced stage, understanding genetic factors regulate pathogenesis each TNM and effects treatment. Therefore, we identified differentially expressed metformin-treated cells investigated their regulatory mechanisms using microRNAs (miRNAs). Through bioinformatics analyses, four-jointed box kinase 1 (FJX1) hsa-miR-1306-3p were as upon Metformin significantly reduced viability, with observed decrease approximately 50%. Analysis quantitative real-time PCR showed increase a FJX1 expression compared untreated cells. Luciferase assay confirmed sequence-specific binding FJX1. These findings highlight therapeutic agent by modulating via upregulation hsa-miR-1306-3p, revealing novel avenues
Язык: Английский
Процитировано
0
Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown
Опубликована: Март 18, 2025
Язык: Английский
Процитировано
0
Discover Nano, Год журнала: 2025, Номер 20(1)
Опубликована: Март 30, 2025
The aim of this study was to explore the bibliometric analysis nanomaterials-based therapies for hepatocellular carcinoma as a means assessing current state development and future trends in field. Literature on nanomedicine interactions searched from core database Web Science visualisation analyses were performed using VOSviewer, CiteSpace GraphPad Prism data software. We focused important keywords, countries, authors, affiliations, journals, literature field nanomaterials HCC. search resulted finalization 421 documents. From 2008 2023, research HCC has developed rapidly, number published papers steadily increased, increasing by about 2300%. There are currently 57 countries involved area. Among them, USA had strongest international cooperation network cooperated most closely with China. Gene delivery carbon nanotubes early immunotherapy nanocarriers recent hotspots. It is that selection drug have become driving carcinoma. combination traditional imaging techniques such MRI can improve diagnosis rate Nanomaterials achieve precise targeting cancer cells encapsulating drugs, loading bioactive molecules or modifying specific ligands, thus significantly improving efficacy effectively reducing adverse reactions therapy.
Язык: Английский
Процитировано
0
BMC Cancer, Год журнала: 2025, Номер 25(1)
Опубликована: Фев. 21, 2025
The interaction between T cells, particularly naïve CD4 cells (CD4Tn), and colorectal cancer (CRC) is highly complex. CD4Tn play a crucial role in modulating immune responses within the tumor microenvironment, yet precise mechanisms by which they influence progression remain elusive. This study aims to explore relationship CRC CD4Tn, identify biomarkers therapeutic targets, focus on of shaping environment CRC. Single-cell transcriptomics, alongside scPagwas algorithm, were employed pivotal cell subsets involved progression. Bulk transcriptomic data further analyzed using deconvolution algorithms elucidate roles these key subsets. abundance (CD4Tn) was specifically assessed gauge patient immunotherapy, alterations correlations with genetic mutations. Key genes linked identified weighted gene co-expression network analysis Pearson correlation scores. SMR algorithm subsequently used for validation, experimental verification following. Through single-cell transcriptomics confirmed as critical type High infiltration patients correlated poorer prognosis suboptimal immunotherapy. suggested potential causal link DRAM2 expression Experimental knockdown significantly inhibited growth. gene, associated appears advancement may represent promising target treatment.
Язык: Английский
Процитировано
0
Frontiers in Medicine, Год журнала: 2025, Номер 12
Опубликована: Март 10, 2025
Many biomolecules and signaling pathways are involved in the development of alcoholic liver disease (ALD). The molecular mechanisms ALD not fully understood there is no effective treatment. Numerous studies have demonstrated critical role non-coding RNAs, including long RNAs (lncRNAs) microRNAs (miRNAs), ALD. miRNAs play an important regulatory pathogenesis by controlling biological processes such as inflammation, oxidative stress, lipid metabolism, apoptosis fibrosis. Among them, miR-155, miR-223 miR-34a a central these influence pathological process In addition, lncRNAs regulating injury repair interacting with to form complex network. These findings help elucidate provide scientific basis for new diagnostic markers therapeutic targets. this article, we review roles LncRNAs their potential use
Язык: Английский
Процитировано
0
Mathematical Biosciences & Engineering, Год журнала: 2024, Номер 21(12), С. 7707 - 7739
Опубликована: Янв. 1, 2024
In the pursuit of personalized medicine, there is a growing demand for computational models with parameters that are easily obtainable to accelerate development potential solutions. Blood tests, owing their affordability, accessibility, and routine use in healthcare, offer valuable biomarkers assessing hemostatic balance thrombotic bleeding disorders. Incorporating these into blood coagulation crucial creating patient-specific models, which allow analysis influence on clot formation. This systematic review aims examine how clinically relevant integrated formation, thereby advancing discussions integration methodologies, identifying current gaps, recommending future research directions. A was conducted following PRISMA protocol, focusing ten significant associated disorders: D-dimer, fibrinogen, Von Willebrand factor, factor Ⅷ, P-selectin, prothrombin time (PT), activated partial thromboplastin (APTT), antithrombin Ⅲ, protein C, S. By utilizing this set biomarkers, underscores emphasizes context venous thromboembolism hemophilia. Eligibility criteria included mathematical thrombin generation, clotting, or fibrin formation under flow, incorporating at least one biomarkers. total 53 articles were review. Results indicate commonly used such as PT, APTT rarely superficially models. Additionally, kinetic governing dynamics demonstrated variability across studies, discrepancies up 1, 000-fold. highlights critical gap availability based phenomenological first-principles approaches effectively incorporate affordable routinely clinical test results predicting coagulation. hinders practical tools application, often fail consider precise, values. limitation especially pronounced patients conditions hemophilia, C S deficiencies, deficiency. Addressing challenges by developing account medicine field hemostasis.
Язык: Английский
Процитировано
1
Progress in Biophysics and Molecular Biology, Год журнала: 2024, Номер unknown
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
0