High-Precision Biochemical Sensing with Resonant Monocrystalline Plasmonic Ag Microcubes in the Mid-Infrared Spectrum DOI
Aidana Beisenova, Wihan Adi,

Shin-Won Kang

и другие.

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Март 27, 2025

Infrared (IR) spectroscopic fingerprinting is a powerful analytical tool for characterizing molecular compositions across biological, environmental, and industrial samples through their specific vibrational modes. Specifically, when the sample characterized in resonant plasmonic cavities, as surface-enhanced mid-IR absorption spectroscopy (SEIRAS), highly sensitive detection can be achieved. However, current SEIRAS techniques rely on nanofabricated subwavelength antennas, limited by low-throughput lithographic processes, lacking scalability to address broad biochemical sensing applications. To this, we present an on-resonance method utilizing silver (Ag) cubic microparticles (Ag-CMPs) with robust resonances. These monocrystalline Ag-CMPs, featuring sharp edges vertices, are synthesized via high-throughput, wet-chemical process. When dispersed gold mirror substrates aluminum oxide spacer, Ag-CMPs support enhanced near-field light-matter interactions nanocavities while enabling far-field imaging-based optical interrogation due strong extinction cross sections. We demonstrate of polydimethylsiloxane (PDMS) bovine serum albumin (BSA) monolayers simply probing individual enabled amplification characteristic absorptions. Furthermore, our single-particle (SP-SEIRAS) approach effectively analyzes complex human peritoneal fluid (PF) samples, eliminating challenges standard bulk measurements. This scalable efficient SP-SEIRAS addresses key limitations IR techniques, unlocking possibilities widespread adoption real-world

Язык: Английский

High-Precision Biochemical Sensing with Resonant Monocrystalline Plasmonic Ag Microcubes in the Mid-Infrared Spectrum DOI
Aidana Beisenova, Wihan Adi,

Shin-Won Kang

и другие.

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Март 27, 2025

Infrared (IR) spectroscopic fingerprinting is a powerful analytical tool for characterizing molecular compositions across biological, environmental, and industrial samples through their specific vibrational modes. Specifically, when the sample characterized in resonant plasmonic cavities, as surface-enhanced mid-IR absorption spectroscopy (SEIRAS), highly sensitive detection can be achieved. However, current SEIRAS techniques rely on nanofabricated subwavelength antennas, limited by low-throughput lithographic processes, lacking scalability to address broad biochemical sensing applications. To this, we present an on-resonance method utilizing silver (Ag) cubic microparticles (Ag-CMPs) with robust resonances. These monocrystalline Ag-CMPs, featuring sharp edges vertices, are synthesized via high-throughput, wet-chemical process. When dispersed gold mirror substrates aluminum oxide spacer, Ag-CMPs support enhanced near-field light-matter interactions nanocavities while enabling far-field imaging-based optical interrogation due strong extinction cross sections. We demonstrate of polydimethylsiloxane (PDMS) bovine serum albumin (BSA) monolayers simply probing individual enabled amplification characteristic absorptions. Furthermore, our single-particle (SP-SEIRAS) approach effectively analyzes complex human peritoneal fluid (PF) samples, eliminating challenges standard bulk measurements. This scalable efficient SP-SEIRAS addresses key limitations IR techniques, unlocking possibilities widespread adoption real-world

Язык: Английский

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