Introducing the antibacterial and photocatalytic degradation potentials of biosynthesized chitosan, chitosan–ZnO, and chitosan–ZnO/PVP nanoparticles

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Июнь 26, 2024

The development of nanomaterials has been speedily established in recent years, yet nanoparticles synthesized by traditional methods suffer unacceptable toxicity and the sustainability procedure for synthesizing such is inadequate. Consequently, green biosynthesis, which employs biopolymers, gaining attraction as an environmentally sound alternative to less sustainable approaches. Chitosan-encapsulated exhibit exceptional antibacterial properties, offering a wide range uses. Chitosan, obtained from shrimp shells, aided friendly synthesis high-purity zinc oxide (ZnO NPs) with desirable features extraction yield (41%), deacetylation (88%), crystallinity index (74.54%). particle size ZnO NPs was 12 nm, while that chitosan-ZnO 21 bandgap energies these were 3.98 3.48, respectively. strong action demonstrated NPs, chitosan-ZnO/PVP, particularly against Gram-positive bacteria, making them appropriate therapeutic use. photocatalytic degradation abilities also assessed all nanoparticles. At concentration 6 × 10

Язык: Английский

---

Phenylpyrazolone-1,2,3-triazole Hybrids as Potent Antiviral Agents with Promising SARS-CoV-2 Main Protease Inhibition Potential

Pharmaceuticals, Год журнала: 2023, Номер 16(3), С. 463 - 463

Опубликована: Март 20, 2023

COVID-19 infection is now considered one of the leading causes human death. As an attempt towards discovery novel medications for pandemic, nineteen compounds containing 1,2,3-triazole side chains linked to phenylpyrazolone scaffold and terminal lipophilic aryl parts with prominent substituent functionalities were designed synthesized via a click reaction based on our previous work. The assessed using in vitro effect growth SARS-CoV-2 virus-infested Vero cells different compound concentrations: 1 10 μM. data revealed that most these derivatives showed potent cellular anti-COVID-19 activity inhibited viral replication by more than 50% no or weak cytotoxic harboring cells. In addition, assay employing SARS-CoV-2-Main protease inhibition was done test inhibitors' ability block common primary virus as mode action. obtained results show non-linker analog 6h two amide-based linkers 6i 6q active IC50 values 5.08, 3.16, 7.55 μM, respectively, against comparison selective antiviral agent GC-376. Molecular modeling studies placement within binding pocket which reveal conserved residues hydrogen bonding non-hydrogen interactions fragments: triazole scaffold, part, linker. Moreover, stability their target also studied analyzed molecular dynamic simulations. physicochemical toxicity profiles predicted, behave low organ toxicity. All research point potential usage new chemotype promising leads be explored vivo might open door rational drug development Main medicines.

Язык: Английский

---

Targeted potent antimicrobial and antitumor oxygen-heterocyclic-based pyran analogues: synthesis and computational studies

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Апрель 29, 2024

Abstract The process of creating a series 3-amino-1-aryl-8-methoxy-1 H -benzo[ f ]chromene-2-carbonitriles ( 4a-q ) involved reacting 6-methoxynaphthalen-2-ol 1 ), the appropriate aromatic aldehydes 2a-q and malononitrile 3 in an absolute ethanol/piperidine solution under Ultrasonic irradiation. However, attempt to create 3-amino-1-aryl-1 ]chromene-2,8-dicarbonitrile 6a, d, e was unsuccessful when 6-cyanonaphthalen-2-ol 5 stirred at room temperature, reflux, Microwave irradiation, or In addition, target molecules were screened against Staphylococcus aureus (MRSA) , Bacillus subtilis, cereus, Escherichia coli Klebsiella pneumonia, as well panel three human cancer cells lines such MCF-7, HCT-116, HepG-2 two normal cell HFL-1 WI-38. obtained results confirmed that pyran derivatives 4 m, i, k which have double chlorine 3,4/2,3/2,5-positions, single halogen atom 3-Cl/4-Br 4c, bromine 3,5-positions with methoxy group 2-position 4n phenyl ring, and, lesser extent, other monoihalogenated 4a, b, dihalogenated g, h, j, l trisubstituent ring 4o, p, q ). Furthermore, compounds 4b-e, n showed negligible activity lines, Moreover, compound g exhibited strongest antimicrobial among 4a-f, g-q compared Ciprofloxacin. MIC assessed for revealing bactericidal effects. Lastly, SAR molecular docking studied.

Язык: Английский

---

Design, synthesis, and mechanistic insight of novel imidazolones as potential EGFR inhibitors and apoptosis inducers

Bioorganic Chemistry, Год журнала: 2024, Номер 144, С. 107105 - 107105

Опубликована: Янв. 8, 2024

Язык: Английский

---

Novel fused imidazotriazines acting as promising top. II inhibitors and apoptotic inducers with greater selectivity against head and neck tumors: Design, synthesis, and biological assessments

European Journal of Medicinal Chemistry, Год журнала: 2023, Номер 259, С. 115661 - 115661

Опубликована: Июль 18, 2023

Язык: Английский

---

A novel class of phenylpyrazolone-sulphonamides rigid synthetic anticancer molecules selectively inhibit the isoform IX of carbonic anhydrases guided by molecular docking and orbital analyses

Journal of Biomolecular Structure and Dynamics, Год журнала: 2023, Номер 41(24), С. 15243 - 15261

Опубликована: Март 13, 2023

All the previously reported phenylpyrazoles as carbonic anhydrase inhibitors (CAIs) were found to have small sizes and high levels of flexibility, hence showed low selectivity profiles toward a particular isoform CA. Herein, we report development more rigid ring system bearing sulfonamide hydrophilic head lipophilic tail develop novel molecules that are suggested better special CA isoform. Accordingly, three sets pyrano[2,3-c]pyrazoles attached with aryl hydrophobic synthesized enhance specific human anhydrases (hCAs). The impact both attachments on potency has been extensively discussed in terms vitro cytotoxicity evaluation under hypoxic conditions, structure-activity relationship enzyme assay. new candidates displayed good cytotoxic activities against breast colorectal carcinomas. Results assay demonstrated preferential compounds 22, 24 27 inhibit IX hCAs selectively. Wound-healing also performed revealed potential decrease wound closure percentage MCF-7 cells. Molecular docking molecular orbital analysis finally conducted. indicate binding interactions several crucial amino acids hCA IX.Communicated by Ramaswamy H. Sarma.

Язык: Английский

---

Discovery of pyranocoumarin derivatives as dual cytotoxic activity against the resistant cancer cell MCF-7/ADR and inhibitory effect of the P-glycoprotein expression levels and function

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 142007 - 142007

Опубликована: Март 1, 2025

Язык: Английский

---

Synthesis, Characterization, Antimicrobial Activity and Molecular Docking Studies of Novel Pyrano[2,3- c ]Pyrazole Derivatives

Polycyclic aromatic compounds, Год журнала: 2025, Номер unknown, С. 1 - 25

Опубликована: Фев. 12, 2025

Язык: Английский

---

Combination therapy and dual-target inhibitors based on cyclin-dependent kinases (CDKs): Emerging strategies for cancer therapy

European Journal of Medicinal Chemistry, Год журнала: 2025, Номер 289, С. 117465 - 117465

Опубликована: Март 1, 2025

Язык: Английский

---

A decade of research effort in synthesis, biological activity assessments, and mechanistic investigations of sulfamethazine‐incorporating molecules

Archiv der Pharmazie, Год журнала: 2025, Номер 358(3)

Опубликована: Март 1, 2025

Abstract Because of its importance in medicinal chemistry, scientific researchers have been interested incorporating sulfamethazine developing biologically active candidates. To achieve this, several synthetic approaches adopted. The adopted included condensation with electrophilic reactants, coupling nucleophilic aromatics and methylene compounds, Knoevenagel condensation, Doebner Miller reaction, microwave‐assisted click cycloaddition, green reaction routes, multicomponent reaction. Linking this molecular scaffold to a variety heterocycles the last 10 years furnished set potential anti‐inflammatory, antiviral, anticancer, antiparkinsonian, neuroprotective, antidiabetic candidates targeting H5N1 NA, epidermal growth factor receptor, acetylcholinesterase (AChE), butylcholinesterase (BChE), human carbonic anhydrase ( h CA), α‐amylase, α‐glucosidase. This review reports all approaches, biological activities studied, structure‐activity relationship analyses, mechanistic investigations reported organic sulfamethazine‐incorporating molecules throughout 2015–2024, based on information retrieved from three search engines: Scopus, PubMed, Google Scholar.

Язык: Английский

---