Adjuvant Properties of Caffeic Acid in Cancer Treatment DOI Open Access

Nicole Cortez,

Cecilia Villegas,

Viviana Burgos

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(14), С. 7631 - 7631

Опубликована: Июль 11, 2024

Caffeic acid (CA) is a polyphenol belonging to the phenylpropanoid family, commonly found in plants and vegetables. It was first identified by Hlasiwetz 1867 as breakdown product of caffetannic acid. CA biosynthesized from amino acids tyrosine or phenylalanine through specific enzyme-catalyzed reactions. Extensive research since its discovery has revealed various health benefits associated with CA, including antioxidant, anti-inflammatory, anticancer properties. These effects are attributed ability modulate several pathways, such inhibiting NFkB, STAT3, ERK1/2, thereby reducing inflammatory responses, activating Nrf2/ARE pathway enhance antioxidant cell defenses. The consumption been linked reduced risk certain cancers, mitigation chemotherapy radiotherapy-induced toxicity, reversal resistance first-line chemotherapeutic agents. This suggests that could serve useful adjunct cancer treatment. Studies have shown be generally safe, few adverse (such back pain headaches) reported. review collates latest information Google Scholar, PubMed, Phenol-Explorer database, ClinicalTrials.gov, incorporating total 154 articles, underscore potential prevention overcoming chemoresistance.

Язык: Английский

Adjuvant Properties of Caffeic Acid in Cancer Treatment DOI Open Access

Nicole Cortez,

Cecilia Villegas,

Viviana Burgos

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(14), С. 7631 - 7631

Опубликована: Июль 11, 2024

Caffeic acid (CA) is a polyphenol belonging to the phenylpropanoid family, commonly found in plants and vegetables. It was first identified by Hlasiwetz 1867 as breakdown product of caffetannic acid. CA biosynthesized from amino acids tyrosine or phenylalanine through specific enzyme-catalyzed reactions. Extensive research since its discovery has revealed various health benefits associated with CA, including antioxidant, anti-inflammatory, anticancer properties. These effects are attributed ability modulate several pathways, such inhibiting NFkB, STAT3, ERK1/2, thereby reducing inflammatory responses, activating Nrf2/ARE pathway enhance antioxidant cell defenses. The consumption been linked reduced risk certain cancers, mitigation chemotherapy radiotherapy-induced toxicity, reversal resistance first-line chemotherapeutic agents. This suggests that could serve useful adjunct cancer treatment. Studies have shown be generally safe, few adverse (such back pain headaches) reported. review collates latest information Google Scholar, PubMed, Phenol-Explorer database, ClinicalTrials.gov, incorporating total 154 articles, underscore potential prevention overcoming chemoresistance.

Язык: Английский

Процитировано

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