Phytochemical Profile and Biological Activities of the Endemic Thymbra nabateorum Occurring in AlUla County, South-West Saudi Arabia
Molecules,
Год журнала:
2025,
Номер
30(3), С. 657 - 657
Опубликована: Фев. 1, 2025
Thymbra
nabateorum,
a
plant
species
from
the
Lamiaceae
family,
is
endemic
to
Nabatian
region,
which
spans
southern
Jordan
and
northwestern
Saudi
Arabia.
It
renowned
for
its
traditional
uses
rich
phytochemical
profile.
This
study
aims
examine
composition
of
T.
nabateorum
evaluate
biological
activities,
including
antioxidant
capacity,
cytotoxic
effects
on
cancer
cell
lines,
enzyme
inhibition
relevant
diabetes
neurodegenerative
diseases.
The
essential
oil
(EO)
methanol
extract
were
analyzed
using
Gas
Chromatography–Mass
Spectrometry
(GC-MS)
High-Performance
Liquid
Chromatography
(HPLC).
Antioxidant
activity
was
assessed
DPPH
radical
scavenging
assay.
Cytotoxicity
evaluated
against
MDA-MB231
LNCaP
lines
MTT
Enzyme
assays
conducted
determine
inhibitory
α-amylase,
α-glucosidase,
butyrylcholinesterase.
GC-MS
analysis
revealed
thymol
(82.30%)
as
major
component
oil,
while
HPLC
identified
significant
phenolic
compounds
in
extract,
diosmin
(118.75
mg/g)
hesperidin
(22.18
mg/g).
assay
demonstrated
strong
activity,
with
showing
an
IC50
11.97
μg/mL
α-amylase
31.99
indicating
notable
antidiabetic
potential.
tests
antiproliferative
both
lower
values
compared
standard
treatments.
exhibits
substantial
antioxidant,
cytotoxic,
supporting
medicinal
uses.
These
findings
provide
scientific
basis
further
research
into
bioactive
potential
applications
modern
pharmacology,
particularly
developing
natural
therapeutic
agents
oxidative
stress-related
diseases
cancer.
Язык: Английский
Updating the Distribution and Conservation Status of the Endemic Nabatean Thyme (Thymbra nabateorum)
Conservation,
Год журнала:
2025,
Номер
5(1), С. 9 - 9
Опубликована: Фев. 18, 2025
Nabatean
thyme
(Thymbra
nabateorum
(Danin
&
Hedge)
Bräuchler)
is
a
perennial
herb
species
under
the
Lamiaceae
family,
first
described
in
1998.
The
thought
to
be
endemic
Jordan
with
only
six
known
records.
However,
recent
fieldwork
has
uncovered
new
patches
of
northwestern
Saudi
Arabia.
This
study
aimed
determine
global
conservation
status
and
update
distribution
thyme.
To
achieve
this,
we
conducted
extensive
used
collected
occurrences
calculate
Extent
Occurrence
(EOO)
Area
Occupancy
(AOO).
We
recorded
sandstone
grooves
within
open
plains
at
altitudes
850
1350
m,
its
largest
population
occurring
outside
historical
range,
rendering
it
northwest
primary
threats
across
range
include
overgrazing,
excessive
harvesting
for
medicinal
purposes,
habitat
fragmentation.
an
EOO
47,585
km²
AOO
136
km².
Accordingly,
recommend
considering
as
Endangered
B2ab(iii)
C2a(ii)
IUCN
criteria.
integrating
both
situ
ex
programs
improve
ensure
sustainability
Язык: Английский