Genes,
Год журнала:
2023,
Номер
14(8), С. 1648 - 1648
Опубликована: Авг. 18, 2023
(1)
Background:
It
was
found
that
the
melanin
of
black-bone
chicken
has
various
effects
such
as
scavenging
DPPH
free
radicals
and
anti-oxidation,
synthesis
is
affected
by
factors
including
hormones.
In
addition,
several
studies
have
melatonin
affects
melanoma
cell
melanin,
which
not
been
reported
in
primary
melanocytes;
so,
relevant
were
conducted.
(2)
Methods:
this
study,
melanocytes
isolated
characterized,
then
treated
with
different
concentrations
to
investigate
on
terms
synthesis-related
genes,
content,
tyrosinase
activity,
combined
RNA
seq
detect
change
gene
expression
level
after
treatment.
(3)
Results:
We
characterized
melanocytes,
indirect
immunofluorescence
assay
results
showed
positive
melanocyte
marker
genes.
RT-qPCR
decreased
reduced
content
activity
group.
A
total
1703
differentially
expressed
genes
screened
RNA-seq,
KEGG
results,
signaling
pathway
associated
synthesis,
mTOR
enriched.
(4)
Conclusions:
Melatonin
could
decrease
melanocytes.
Investigative Ophthalmology & Visual Science,
Год журнала:
2025,
Номер
66(1), С. 19 - 19
Опубликована: Янв. 8, 2025
Purpose:
This
study
investigated
the
impact
of
hyperglycemia
in
type
2
diabetes
mellitus
(T2DM)
on
circadian
rhythms
and
function
lacrimal
glands
(LGs)
contributing
to
dry
eye
syndrome.
We
assessed
effects
gene
expression,
immune
cell
recruitment,
neural
activity,
metabolic
pathways,
evaluated
effectiveness
insulin
restoring
normal
LG
function.
Methods:
Using
a
T2DM
mouse
model
(db/db
mice),
transcriptomic
changes
LGs
were
analyzed
through
RNA
sequencing
over
24-hour
period.
Rhythmic
expression
core
clock
genes,
pathways
evaluated.
The
treatment
these
parameters
also
assessed.
Results:
Hyperglycemia
disrupted
genes
LGs,
leading
50%
reduction
rhythmic
expression.
was
associated
with
altered
impaired
changes.
Insulin
lowered
blood
glucose
levels
but
did
not
restore
or
tear
secretion,
exacerbating
syndrome
diabetic
mice.
Conclusions:
significantly
disrupts
glands,
limited
efficacy
regulation
suggests
that
hyperglycemia-induced
dysfunction
is
solely
dependent
levels,
highlighting
need
for
therapies
targeting
ocular
complications.
Biology,
Год журнала:
2023,
Номер
13(1), С. 22 - 22
Опубликована: Дек. 30, 2023
This
study
explores
the
relationship
between
light
features
of
Arctic
spring
equinox
and
circadian
rhythms,
sleep
metabolic
health.
Residents
(N
=
62)
provided
week-long
actigraphy
measures,
including
exposure,
which
were
related
to
body
mass
index
(BMI),
leptin
cortisol.
Lower
wrist
temperature
(wT)
higher
evening
blue
exposure
(BLE),
expressed
as
a
novel
index,
nocturnal
excess
(NEIbl),
most
sensitive
measures
associated
with
BMI.
A
BMI
was
linked
BLE
within
distinct
time
windows.
These
associations
present
specifically
in
carriers
MTNR1B
rs10830963
G-allele.
larger
wake-after-sleep
onset
(WASO),
smaller
24
h
amplitude
earlier
phase
activity
rhythm
leptin.
Higher
cortisol
an
M10
our
other
Daylight
Deficit
Index
light,
DDIbl.
We
also
found
sex-,
age-
population-dependent
differences
parametric
non-parametric
indices
BLE,
wT
physical
activity,
while
there
no
any
characteristics.
Overall,
this
determined
markers
predictive
health
showed
that
these
are
melatonin
receptor
polymorphism.
Science Signaling,
Год журнала:
2025,
Номер
18(881)
Опубликована: Апрель 8, 2025
Sleep
loss
dysregulates
cellular
metabolism
and
energy
homeostasis.
Highly
metabolically
active
cells,
such
as
neurons,
enter
a
catabolic
state
during
periods
of
sleep
loss,
which
consequently
disrupts
physiological
functioning.
Specific
to
the
central
nervous
system,
results
in
impaired
synaptogenesis
long-term
memory,
effects
that
are
also
characteristic
neurodegenerative
diseases.
In
this
review,
we
describe
how
deprivation
increases
resting
expenditure,
leading
development
negative
balance—a
with
insufficient
metabolic
resources
support
expenditure—in
highly
cells
like
neurons.
This
disruption
energetic
homeostasis
alters
balance
metabolites,
including
adenosine,
lactate,
lipid
peroxides,
energetically
costly
processes,
synapse
formation,
attenuated.
During
shunt
away
from
those
processes
not
acutely
essential,
memory
cell
survival.
Ultimately,
these
findings
characterize
disorder.
World Journal of Diabetes,
Год журнала:
2025,
Номер
16(5)
Опубликована: Апрель 24, 2025
BACKGROUND
There
are
conflicting
results
on
the
potential
correlation
between
folic
acid
and
gestational
diabetes
mellitus
(GDM),
genetic
factors
related
to
metabolism
pathways
GDM
remains
be
revealed.
AIM
To
examine
association
single-nucleotide
polymorphisms
(SNPs)
of
enzyme
genes
in
folate
metabolite
pathway
as
well
that
GDM-related
risk
for
GDM.
METHODS
A
nested
case-control
study
was
conducted
with
cases
(n
=
412)
healthy
controls
412).
DNA
extracted
blood
samples
SNPs
were
genotyped
using
Agena
Bioscience’s
MassARRAY
gene
mass
spectrometry
system.
The
associations
different
estimated
logistic
regression
models.
generalized
multi-factor
dimensionality
reduction
(GMDR)
method
used
analyze
gene-gene
gene-environment
interactions
GMDR
0.9
software.
RESULTS
variation
allele
frequency
melatonin
receptor
1B
(MTNR1B
)
rs10830963
higher
group
than
(P
<
0.05).
MTNR1B
mutant
G
associated
[adjusted
odds
ratio
(aOR):
1.43;
95%
confidence
interval
(95%CI):
1.13-1.80]
additive
model.
GG
+
GC
significantly
(aOR:
1.65;
95%CI:
1.23-2.22)
dominant
two-locus
model
CHEMERIN
rs4721
best
0.05)
results.
high-risk
×
type
interaction
a
factor
2.09;
1.49-2.93).
CONCLUSION
This
does
not
find
an
metabolic
enzymes
is
identified
model,
there
may
rs4721.
It
conducive
studying
causes
provides
new
perspective
precise
prevention
this
disease.
