SARS‐CoV‐2 Vaccination is Not Associated With Involuntary Childlessness in Female Healthcare Workers: A Multicenter Cohort Study DOI Creative Commons

Tamara Dörr,

Sabine Güsewell,

Alexia Cusini

и другие.

Influenza and Other Respiratory Viruses, Год журнала: 2024, Номер 18(6)

Опубликована: Июнь 1, 2024

ABSTRACT Background There is debate about the causes of recent birth rate decline in high‐income countries worldwide. During pandemic, concern effects on reproductive health has caused vaccine hesitancy. We investigated association SARS‐CoV‐2 vaccination and infection with involuntary childlessness. Methods Females fertility age within a prospective multicenter cohort healthcare workers (HCW) were followed since August 2020. Data baseline health, SARS‐CoV‐2‐infection, obtained regularly updated, which serum samples collected repetitively screened for anti‐nucleocapsid anti‐spike antibodies. In October 2023, participants indicated presence childlessness onset during whereas those indicating an before pandemic excluded. The SARS‐CoV‐2‐vaccination was using univariable multivariable analysis. Sensitivity analysis performed to compare reporting birthing child Results Of 798 participants, 26 (3.2%) reported starting pandemic. childless women, 73.1% (19/26) vaccinated compared 86.0% (664/772) without ( p = 0.73). by 76.9% (20/26) 72.4% (559/772) controls 0.64). Neither (aOR 0.91 per dose, 95%CI 0.67–1.26) nor 1.05, 0.62–1.71) associated confirmed these results. Conclusions Among female HCW age, 3.2% childlessness, comparable pre‐pandemic data. No between or found.

Язык: Английский

Birth rate decline in the later phase of the COVID-19 pandemic: the role of policy interventions, vaccination programmes and economic uncertainty DOI Creative Commons
Maria Winkler‐Dworak, Kryštof Zeman, Tomáš Sobotka

и другие.

Human Reproduction Open, Год журнала: 2024, Номер 2024(3)

Опубликована: Янв. 1, 2024

Abstract STUDY QUESTION What are the factors influencing decline in birth rates observed higher-income countries later phase of COVID-19 pandemic? SUMMARY ANSWER Our results suggest that economic uncertainty, non-pharmaceutical policy interventions, and first wave population-wide vaccination campaign were associated with during 2022. WHAT IS KNOWN ALREADY During pandemic, most briefly declined then shortly recovered, showing no common trends afterwards until early 2022, when they unexpectedly dropped. DESIGN, SIZE, DURATION This study uses data on monthly total fertility (TFRs) adjusted for seasonality calendar effects provided Human Fertility Database (HFD). Births taking place between November 2020 October 2022 correspond to conceptions occurring February January i.e. after onset pandemic but prior Russian invasion Ukraine. The cover 26 countries, including 21 Europe, USA, Canada, Israel, Japan, Republic Korea. PARTICIPANTS/MATERIALS, SETTING, METHODS First, we a descriptive analysis changes TFR. Second, employed linear fixed regression models estimate association explanatory seasonally TFRs. considered three broader sets factors: interventions restricting mobility social activities outside home, progression programmes. MAIN RESULTS AND THE ROLE OF CHANCE We found as measured by increased inflation (P < 0.001), whereas unemployment did not show any link births = 0.677). stringency was linked postponement births, only lower institutional trust 0.003). In higher trust, stricter containment measures positively rates, both year 0.019) and, albeit weakly significant, 0.057). Furthermore, negative share population having received dose TFRs completed primary course (usually consisting two doses) recovery 0.001). LARGE SCALE DATA N/A. LIMITATIONS, REASONS FOR CAUTION research is restricted relatively strong support policies government well wide access modern contraception. allow analyses key characteristics, such age, order, status. WIDER IMPLICATIONS FINDINGS multi-country drivers pandemic. past, periods following epidemics health crises typically births. contrast, our gradual phasing out measures, allowing return more normal work life, contributed declining some countries. addition, indicates women avoided pregnancy completion protocol. FUNDING/COMPETING INTEREST(S) use external funding. authors acknowledge funding from their home institution, Vienna Institute Demography Austrian Academy Sciences, Open-Access Fund Sciences. For purpose open access, have applied CC BY public copyright licence Author Accepted Manuscript versions arising this submission. All declare conflicts interest.

Язык: Английский

Процитировано

5

Fertility decline in the later phase of the COVID-19 pandemic: The role of policy interventions, vaccination programmes, and economic uncertainty DOI Creative Commons
Maria Winkler‐Dworak, Kryštof Zeman, Tomáš Sobotka

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Апрель 28, 2024

Abstract BACKGROUND During the COVID-19 pandemic, birth rates in most higher-income countries first briefly declined and then shortly recovered, showing no common trends afterwards until early 2022, when they unexpectedly dropped. STUDY FOCUS We analyse monthly changes total fertility during with a special focus on countries. consider three broader sets of explanatory factors: economic uncertainty, policy interventions restricting mobility social activities outside home, role vaccination programmes. DESIGN, DATA This study uses population-wide data adjusted for seasonality calendar effects provided Human Fertility Database (HFD, 2023). Births taking place between November 2020 October 2022 correspond to conceptions occurring February January i.e., after onset pandemic but prior Russian invasion Ukraine. The cover 26 countries, including 21 Europe, United States, Canada, Israel, Japan Republic Korea. METHODS First, we provide descriptive analysis rate (TFR). Second, estimate factors observed swings using linear fixed (within) regression models. MAIN RESULTS find that were associated as measured by increased inflation, stringency interventions, progression campaign, whereas unemployment did not show any link pandemic. LIMITATIONS, REASONS FOR CAUTION Our research is restricted relatively strong support policies government well wide access modern contraception. do allow analysing key characteristics, such age, order status. WIDER IMPLICATIONS OF THE FINDINGS multi-country drivers later phase In past, periods following epidemics health crises typically recovery fertility. contrast, our results gradual phasing out containment measures, allowing return more normal work life, contributed declining addition, indicates some women avoided pregnancy initial roll-out.

Язык: Английский

Процитировано

4

Fertility dynamics through historical pandemics and COVID-19 in Switzerland, 1871–2022 DOI Creative Commons
Katarina L. Matthes, Mathilde Le Vu, Kaspar Staub

и другие.

Population Studies, Год журнала: 2025, Номер unknown, С. 1 - 16

Опубликована: Март 11, 2025

We follow general fertility rates (GFRs) in Switzerland up to 2022, with a focus on their dynamics during and after pandemics. Historical influenza pandemics (1889–90, 1918–20, 1957) have consistently led temporary declines births between six nine months the pandemic peak. High of miscarriage may explain these findings. After 1889–90 1918–20 pandemics, short-term baby booms occurred. For recent Covid-19 pandemic, appear more complex. The GFR had already been declining since 2018, before hit Switzerland. During shortly first two waves 2020, there was an increase conceptions, leading higher 2021: shutdown measures brought planned pregnancies forwards. Subsequently, declined from February 2022; one possible explanation is that were intentionally postponed until vaccination. Following population-level observations, in-depth studies are needed understand better why affected by

Язык: Английский

Процитировано

0

COVID-19 vaccination and birth outcomes of 186,990 women vaccinated before pregnancy: an England-wide cohort study DOI Creative Commons
Arun S Karthikeyan, Rachel Denholm,

Matthew Retford

и другие.

The Lancet Regional Health - Europe, Год журнала: 2024, Номер 45, С. 101025 - 101025

Опубликована: Авг. 13, 2024

COVID-19 vaccination in pregnancy is recommended by the World Health Organisation as effective and safe. However, there remains a lack of robust evidence to inform choices for women childbearing potential relation their future pregnancies. Here we investigated association between starting course before birth outcomes. We analysed England-wide linked electronic health records all pregnancies reaching at least 24 weeks gestation 25th May 2021 28th October 2022. estimated incidence rates hazard ratios outcomes pre-pregnancy status. Based on 186,990 women, compared unvaccinated, receiving within 12 months was associated with lower risks very extremely preterm small-for-gestational age term babies any vaccine type (adjusted ratio 95% confidence interval: 0.74 [0.63, 0.88] 0.94 [0.88, 1.00], respectively), stillbirth risk those an mRNA (0.72 [0.52, 1.00]). Incidence venous thromboembolism during higher amongst viral-vector, but not (1.54 [1.10, 2.16] 1.02 [0.70, 1.50], respectively). Results were generally consistent different dose regimens across sensitivity analyses. found that from first vaccination, unvaccinated experienced fewer adverse outcomes, overall or selected subgroups general population, accounting confounders. An should be preferred viral-vector vaccine, minimise safety issues, where latter only choice, it still unvaccinated. The substantially attributable SARS-CoV-2 infection commonly used medications such hormone replacement therapy oral contraceptives non-pregnant population. UK National Institute Care Research (NIHR), UKRIMedical Council, Innovation, Alan Turing Institute, Data UK, Department Social Care.

Язык: Английский

Процитировано

3

Oncofertility and Fertility Preservation for Women with Gynecological Malignancies: Where Do We Stand Today? DOI Creative Commons
Valentina Di Nisio, Nikoletta Daponte, Christina I. Messini

и другие.

Biomolecules, Год журнала: 2024, Номер 14(8), С. 943 - 943

Опубликована: Авг. 3, 2024

Oncofertility is a growing medical and research field that includes two main areas: oncology reproductive medicine. Nowadays, the percentage of patients surviving cancer has exponentially increased, leading to need for intervention fertility preservation in both men women. Specifically, gynecological malignancies women pose an additional layer complexity due organs being affected. In present review, we report options with cancer- stage-specific focus. We explore drawbacks necessity planning applications during emergency statuses (i.e., COVID-19 pandemic) comment on importance repro-counseling multifaceted their oncological journey.

Язык: Английский

Процитировано

2

Intention to vaccinate chronic disease children against COVID-19; a multicenter survey DOI Creative Commons
Ramy Mohamed Ghazy, Sally Waheed Elkhadry, Engy Saad Abdelmoneim Elkaragy

и другие.

Egyptian Pediatric Association Gazette, Год журнала: 2023, Номер 71(1)

Опубликована: Дек. 4, 2023

Abstract Background Vaccination against severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) has gained recognition as a crucial strategy to prevent and reduce the risk of infection, including emerging variants, due its proven safety, immunogenicity, effectiveness. This study aimed evaluate vaccination hesitancy (VH) among Egyptian parents towards SARS-CoV-2 vaccination, specifically focusing on with chronically ill children. Method A multicentered cross-sectional survey was conducted at outpatient clinics El-Raml Pediatric Hospital, Ministry Health Population (MOHP) in Alexandria, Alexandria Main University Hospital for Maternity Children (AMUH), Al-Galaa Teaching General Organization Hospitals Institutes (GOTHI) Cairo, Department, Menoufia from May 1 st till December 15 th , 2022. Parents children chronic diseases were recruited using simple random sampling technique respond validated Arabic version parental attitudes about childhood (PACV). Results In this study, we enrolled 527 caregivers, 55.4% them aged 30–39 years old, 85.2% females, 46.9% had diseases. Commonly mentioned information sources included television radio (69.8%), social media (35.3%). Among studied, 59.6% refused vaccination. The predictors PACV score governorate, (β = 11.30, 95%CI [5.32, 17.27], p < 0.001), setting, -20.07, [-25.40, -14.75] -10.74, [-14.50, -6.98], income; not enough loans repaid 3.18, [0.54, 5.82], 0.018) 3.57,95%CI [0.08, 7.07], 0.045). Conclusions reveals geographic economic factors PACV, emphasizes need region-specific interventions financial barriers improve vaccine acceptance child well-being.

Язык: Английский

Процитировано

6

The remarkable ups and downs of birth rate in Switzerland 2020 to 2023 in a historical context DOI Creative Commons
Mathilde Le Vu, Katarina L. Matthes, Kaspar Staub

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Дек. 5, 2023

Abstract We follow population trends in the monthly birth rate Switzerland almost up to present and place latest developments a historical context. Birth rates 2022 were lowest since 1870s, trend is continuing 2023. The decline had already begun 1-2 years before Covid-19. Previous pandemics (1890, 1918, 1920, 1957) led temporary births ∽9 months after epidemic peaks. With Covid-19, this appears more complex. During shortly first two waves shutdowns 2020, there conceptions thus excess 2021, all available subgroups except Italian-speaking Switzerland, somewhat pronounced among >30-year-old mothers second parities. Possible reasons for mini-boom include: increased time at home during has – planned or not which brought pregnancies forward; corona virus was still circulat-ing too infrequently 1st phase of pandemic have negative impact on fertility; end shutdowns, perceived threat could an optimistic mood also conceptions. subsequent from January stronger than in-crease before. part most likely due rebound advance-ment 2020/2021 deliberately postponed start vaccination pro-gram. associated with large Omicron wave winter 2021/2022, when many people fell ill. In addition, prices been rising real wages falling global political situation become unstable, general change values regarding willingness children may be underway. Following these observations level (with limited depth variables), in-depth studies must now better under-stand dynamic ups downs recent years.

Язык: Английский

Процитировано

3

Influences of race, ethnicity, and other social factors on coronavirus disease 2019 vaccination uptake among patients undergoing in vitro fertilization DOI
Leigh Ann Humphries, Jeremy Applebaum, Florencia Greer Polite

и другие.

Fertility and Sterility, Год журнала: 2024, Номер 122(2), С. 376 - 378

Опубликована: Апрель 19, 2024

Язык: Английский

Процитировано

0

SARS‐CoV‐2 Vaccination is Not Associated With Involuntary Childlessness in Female Healthcare Workers: A Multicenter Cohort Study DOI Creative Commons

Tamara Dörr,

Sabine Güsewell,

Alexia Cusini

и другие.

Influenza and Other Respiratory Viruses, Год журнала: 2024, Номер 18(6)

Опубликована: Июнь 1, 2024

ABSTRACT Background There is debate about the causes of recent birth rate decline in high‐income countries worldwide. During pandemic, concern effects on reproductive health has caused vaccine hesitancy. We investigated association SARS‐CoV‐2 vaccination and infection with involuntary childlessness. Methods Females fertility age within a prospective multicenter cohort healthcare workers (HCW) were followed since August 2020. Data baseline health, SARS‐CoV‐2‐infection, obtained regularly updated, which serum samples collected repetitively screened for anti‐nucleocapsid anti‐spike antibodies. In October 2023, participants indicated presence childlessness onset during whereas those indicating an before pandemic excluded. The SARS‐CoV‐2‐vaccination was using univariable multivariable analysis. Sensitivity analysis performed to compare reporting birthing child Results Of 798 participants, 26 (3.2%) reported starting pandemic. childless women, 73.1% (19/26) vaccinated compared 86.0% (664/772) without ( p = 0.73). by 76.9% (20/26) 72.4% (559/772) controls 0.64). Neither (aOR 0.91 per dose, 95%CI 0.67–1.26) nor 1.05, 0.62–1.71) associated confirmed these results. Conclusions Among female HCW age, 3.2% childlessness, comparable pre‐pandemic data. No between or found.

Язык: Английский

Процитировано

0