Pathology - Research and Practice, Год журнала: 2024, Номер 263, С. 155591 - 155591
Опубликована: Сен. 10, 2024
Язык: Английский
DNA and Cell Biology, Год журнала: 2025, Номер unknown
Опубликована: Март 21, 2025
The occurrence of diabetic kidney disease (DKD), a critical microvascular issue in diabetes, is progressively on the rise. In recent years, long noncoding RNAs (lncRNAs) have garnered considerable attention as novel and layer biological regulation. Our knowledge regarding roles underlying mechanisms lncRNAs various diseases, including DKD, continues to evolve. Similarly, microRNAs (miRNAs), which are small RNAs, been recognized crucial contributors cellular processes pathogenesis. Emerging studies highlighted complex interactions between miRNAs, particularly context underscoring their importance human diseases. Renal intrinsic cell damage an important cause inducing DKD. Persistent high glucose stimulation leads remodeling renal cells cascade pathological changes. This article aims review literature lncRNAs-mediated regulation miRNAs affecting DKD propose molecular-level therapeutic strategies for Through in-depth investigation this dynamic molecular interaction, we can gain profound understanding potential nephropathy, potentially identifying new targets intervention paving way personalized effective treatments.
Язык: Английский
Процитировано
1
International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 3007 - 3030
Опубликована: Март 1, 2025
Abstract: Kidney disease is a major public health concern that has significant effect on patient's life span and quality of life. However, effective treatment for most kidney diseases lacking. Nanotechnology mainly explores the design, characterization, production, applications objects in nanoscale range been widely used medical field. To date, there an increasing amount research application nanotechnology disease. systematic bibliometric studies remain rare. In this review, data collected from Web Science Core Collection database until December 31, 2024, were subjected to analysis. A total 1179 articles reviews included. The publication trends, countries, institutions, authors, co-authorship, co-citations, journals, keywords, references pertaining topic examined. results showed increasing. leading country, organization, author China, Sichuan University, Professor Peng Huang, respectively. ACS APPLIED MATERIALS & INTERFACES was top journal among 464 journals which published. KIDNEY INTERNATIONAL cited increases shown "acute disease", "drug delivery", "oxidative stress", "diabetic nephropathy", "chronic indicating current hotspots. Furthermore, development prospects challenges discussed review. How achieve precise drug delivery render kidney-targeting therapy reality may be problematic future studies. Keywords: nanomedicine, disease, analysis, delivery, diagnosis,
Язык: Английский
Процитировано
0
Clinical and Applied Thrombosis/Hemostasis, Год журнала: 2025, Номер 31
Опубликована: Март 1, 2025
Carotid artery stenosis (CAS) often goes undetected until it reaches an advanced stage, which can result in serious complications. The present study evaluated the potential of long noncoding RNA (lncRNA) LINC01088 as a biomarker for CAS. 92 CAS patients and healthy controls (Control group) were included. RT-qPCR was performed to assess relative levels miR-195-5p. Receiver operating characteristic (ROC) curve used evaluate diagnostic LINC01088. relationship between miR-195-5p identified by luciferase reporter assay. Proliferation, migration, apoptosis human aortic endothelial cells (HAECs) assessed using CCK8, transwell, flow cytometry DAVID employed Kyoto Encyclopedia Genes Genomes (KEGG) Gene Ontology (GO) analyses. showed decreased expression increased compared Control, with negative correlation their demonstrated high sensitivity specificity distinguishing from individuals. directly targets Upregulation reversed effects ox-LDL treatment, restoring proliferation migration while reducing HAECs. However, mimic reduced protection on HAECs proliferation, apoptosis. For target genes, GO revealed protein metabolism pathways KEGG highlighted p53 MAPK signaling pathways. diagnosis value ox-LDL-induced apoptosis, acting sponges may serve protective progression.
Язык: Английский
Процитировано
0
Pathology - Research and Practice, Год журнала: 2024, Номер 263, С. 155591 - 155591
Опубликована: Сен. 10, 2024
Язык: Английский
Процитировано
1