Human and Murine Toll-like Receptor-Driven Disease in Systemic Lupus Erythematosus
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(10), С. 5351 - 5351
Опубликована: Май 14, 2024
The
pathogenesis
of
systemic
lupus
erythematosus
(SLE)
is
linked
to
the
differential
roles
toll-like
receptors
(TLRs),
particularly
TLR7,
TLR8,
and
TLR9.
TLR7
overexpression
or
gene
duplication,
as
seen
with
Y-linked
autoimmune
accelerator
(Yaa)
locus
agonist
imiquimod,
correlates
increased
SLE
severity,
specific
polymorphisms
gain-of-function
variants
are
associated
enhanced
susceptibility
severity.
In
addition,
X-chromosome
location
its
escape
from
inactivation
provide
a
genetic
basis
for
female
predominance
in
SLE.
absence
TLR8
TLR9
have
been
shown
exacerbate
detrimental
effects
leading
upregulated
activity
disease
severity
mouse
models
regulatory
functions
proposed
involve
competition
endosomal
trafficking
chaperone
UNC93B1.
However,
recent
evidence
implies
more
direct,
on
activity.
association
between
age-associated
B
cells
(ABCs)
autoantibody
production
positions
these
potential
targets
treatment
SLE,
but
lack
markers
necessitates
further
research
precise
therapeutic
intervention.
Therapeutically,
targeting
TLRs
promising
strategy
treatment,
drugs
like
hydroxychloroquine
already
clinical
use.
Язык: Английский
Animal models of autoimmunity: a relentless pursuit of accurate pre-clinical models
Autoimmunity,
Год журнала:
2025,
Номер
58(1)
Опубликована: Фев. 5, 2025
Язык: Английский
Drug repurposing for glomerular diseases: an underutilized resource
Nature Reviews Nephrology,
Год журнала:
2024,
Номер
20(11), С. 707 - 721
Опубликована: Июль 31, 2024
Язык: Английский
Progress in the field of animal models of antiphospholipid syndrome
Autoimmunity,
Год журнала:
2024,
Номер
57(1)
Опубликована: Авг. 18, 2024
Antiphospholipid
syndrome
(APS)
is
an
autoimmune
disease
characterized
by
recurrent
arteriovenous
thrombosis
and
pathological
pregnancy,
accompanied
persistent
antiphospholipid
antibodies,
(aPL).
The
incidence
of
APS
increasing
year
year,
clinicians
lack
understanding
this
type
disease,
easy
to
misdiagnose
miss
the
diagnosis.
Therefore,
it
extremely
important
establish
a
suitable
animal
model
reduce
process
development
as
much
possible
improve
clinicians'
understanding.
This
review
will
summarize
models
from
aspects
modeling
methods,
mechanism,
evaluation
indicators
advantages
disadvantages
providing
reference
for
finding
highly
similar
human
APS,
helping
researchers
further
clarify
pathogenesis
find
potential
therapeutic
targets,
so
achieve
early
diagnosis,
intervention,
ultimately
prognosis
patients.
Язык: Английский
Plasma exosomes may mediate the development of lupus nephritis in patients with systemic lupus erythematosus
Lupus,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 31, 2024
Background
Lupus
nephritis
(LN)
is
the
most
serious
complication
of
systemic
lupus
erythematosus
(SLE),
and
plasma
exosomes
may
serve
as
a
bridge.
MicroRNAs
(miRNAs)
are
abundant
in
exosomes,
so
this
study
aimed
to
explore
role
exosome-derived
miRNA
development
LN.
Methods
The
publicly
available
data
containing
exosomal
miRNAs
SLE
patients
healthy
controls
were
researched,
differential
expression
functional
enrichment
analysis
was
conducted.
Then,
from
extracted,
accuracy
preliminarily
verified.
PKH26
dye
used
label
detect
whether
can
enter
HK2
cells.
Evaluation
impact
on
cell
viability
done
by
utilizing
CCK-8
assay.
Flow
cytometry
measure
apoptosis.
Results
Plasma
successfully
extracted
identified.
Through
pulbilic
subsequent
qPCR
validation,
we
observed
that
miR-20b-5p
overexpressed
patients,
whereas
miR-181a-2-3p
downregulated.
Then
revealed
these
primarily
regulate
processes
such
apoptosis,
autophagy,
inflammation.
flow
conducted
after
co-incubation
peripheral
blood
mononuclear
cells
confirmed
indeed
And
without
affecting
activity.
In
addition,
promote
apoptosis
autophagy.
Overexpression
could
inhibit
upregulate
bcl2,
beclin1.
At
same
time,
trend
towards
increased
rates
miR-20b-5p,
although
difference
did
not
reach
statistical
significance.
enhance
caspase3
becin1
while
suppressing
bcl2
LC3β.
Conclusion
Our
research
indicates
presence
depletion
mediate
promotion
autophagy
cells,
thereby
causing
kidney
damage
Язык: Английский
Characterization of Dendritic Cells and Myeloid-Derived Suppressor Cells Expressing Major Histocompatibility Complex Class II in Secondary Lymphoid Organs in Systemic Lupus Erythematosus-Prone Mice
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(24), С. 13604 - 13604
Опубликована: Дек. 19, 2024
Systemic
lupus
erythematosus
(SLE)
is
an
autoimmune
disease
characterized
by
self-antibody
production
and
widespread
inflammation
affecting
various
body
tissues.
This
driven
the
breakdown
of
immune
tolerance,
which
promotes
activation
autoreactive
B
T
cells.
A
key
feature
SLE
dysregulation
in
antigen
presentation,
where
antigen-presenting
cells
(APCs)
play
a
central
role
perpetuating
responses.
Dendritic
(DCs)
are
highly
specialized
for
presentation
among
APCs.
At
same
time,
myeloid-derived
suppressor
(MDSCs)
can
also
express
MHC-II
molecules,
although
their
less
understood.
Utilizing
model,
MRL/MpJ-Faslpr/J,
we
determined
presence
different
phenotypes
DCs
MDSCs
expressing
secondary
lymphoid
organs,
along
with
gene
expression
ICOSL,
CD80
CD86
spleen.
Our
study
that
most
abundant
population
APCs
organs
corresponds
to
cDC
CD103−CD11b+
MHC-II+
throughout
development.
Additionally,
ICOSL
increased
over
becoming
more
preponderant
week
16
could
indicate
it
crucial
pathway
development
progression
pathology.
In
16,
observed
positive
correlation
between
M-MDSC
IFN-γ-producing
CD4+
Язык: Английский