Increased MASH-associated liver cancer in younger demographics
Hepatology Communications,
Год журнала:
2025,
Номер
9(1)
Опубликована: Янв. 1, 2025
Background:
The
incidence
of
cancer
and
the
prevalence
metabolic
disease
dysfunction–associated
steatotic
liver
is
increasing
in
young
adults.
However,
updated
global
data
on
steatohepatitis
(MASH)-associated
primary
(PLC)
adults
remains
scarce.
Methods:
This
study
analyzed
from
Global
Burden
Disease
between
2000
2021
to
assess
age-standardized
incidence,
mortality,
disability-adjusted
life
years
rates
MASH-associated
PLC
(15–49
y).
Results:
In
2021,
there
were
4300
cases,
3550
deaths,
179,340
Among
various
etiologies
adults,
only
had
increased
(annual
percent
change:
+0.26,
95%
CI:
0.16%–0.35%),
with
Eastern
Mediterranean
region
having
largest
observed
increase
1.46%,
1.40%–1.51%).
made
up
6%
(+1%
2000)
incident
(+2%
all
this
age
group.
Over
half
countries
exhibited
an
rate
2021.
Conclusions:
significantly
increasing,
signaling
likely
future
increases
among
older
as
cohort
ages.
trend
necessitates
urgent
strategies
worldwide
mitigate
epidemics
Язык: Английский
Global burden and cross-country health inequalities of early-onset colorectal cancer and its risk factors from 1990 to 2021 and its projection until 2036
BMC Public Health,
Год журнала:
2024,
Номер
24(1)
Опубликована: Ноя. 12, 2024
To
explore
the
worldwide,
regional,
and
country-specific
burden
of
early-onset
colorectal
cancer
(EO-CRC)
identify
its
associated
risk
factors
between
1990
2021,
to
project
incidence
mortality
rates
for
2036.
We
acquired
data
on
EO-CRC
categorized
by
gender,
socio-demographic
index
(SDI),
based
Global
Burden
Disease
(GBD)
Study
2021.
Joinpoint
regression
analysis
was
utilized
variation
in
disease
burden.
The
autoregressive
integrated
moving
average
(ARIMA)
model
performed
forecast
up
Globally,
rate,
prevalence
disability-adjusted
life
years
(DALYs)
rate
were
estimated
at
5.37
(95%UI:
4.91
5.86)/100,000,
34
30.96
37.35)/100,000,
2.01
1.84
2.19)/100,000,
101.37
(95%:
92.85
110.18)/100,000
showed
an
ascending
trajectory,
whilst
DALYs
demonstrated
a
downward
trajectory
high-middle
SDI
regions
East
Asia
exhibited
highest
among
five
21
GBD
respectively.
A
low-whole-grains
diet
chief
factor
contributing
EO-CRC.
It
predicted
that
age-standardized
(ASR)
would
increase
5.56%,
while
ASR
decrease
13.9%
globally
until
current
future
global
is
heavy
varies
significantly
across
different
countries.
Язык: Английский
An update on the incidence rates of early onset vs late onset colon cancer among Whites, Blacks, Hispanics, and Asian-American/Pacific Islanders in the United States
Baylor University Medical Center Proceedings,
Год журнала:
2025,
Номер
unknown, С. 1 - 4
Опубликована: Апрель 22, 2025
Язык: Английский
Young Onset Colorectal Cancer
Lietuvos chirurgija,
Год журнала:
2025,
Номер
24(2), С. 92 - 97
Опубликована: Май 5, 2025
Early
onset
colorectal
cancer
-
cacner,
appearing
in
a
patient
population
below
50
years
of
age.
Disease
is
more
aggressive,
and
diagnosis
likely
an
advanced
stage.
The
increase
the
incidence
this
form
disease
globally
requires
mature
prevention
treatment
options.
Язык: Английский