Journal of Psychopharmacology,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 3, 2024
Posttraumatic
stress
disorder
(PTSD)
is
a
condition
that
can
develop
after
traumatic
event,
causing
distressing
symptoms,
including
intrusive
re-experiencing
alterations
in
mood
and
cognition,
changes
arousal
reactivity.
Few
treatment
options
exist
for
patients
who
find
conventional
psychotherapy
pharmacotherapy
to
be
inaccessible,
ineffective,
or
intolerable.
We
explore
psilocybin
as
potential
option
PTSD
by
examining
the
neurobiology
of
well
psilocybin’s
mechanism
action.
Based
on
both
pharmacodynamic
psychoanalytic
principles,
may
an
underexplored
with
PTSD,
though
further
research
required.
Post-traumatic
stress
disorder
(PTSD)
is
an
anxiety
that
often
presents
after
exposure
to
a
traumatic,
life-threatening
event.
Experiencing
traumatic
event
not
rare,
with
inciting
incidents
ranging
from
being
burglarized
politically
motivated
genocide.
While
traditional
psychopharmacology
and
psychotherapy
are
the
mainstays
of
treatment
PTSD
currently,
psychoactive
drugs
(otherwise
known
as
psychedelics)
explored
for
their
novel
role
in
patients.
Psychoactive
such
MDMA,
ketamine,
psilocybin
have
been
shown
specifically
target
decrease
fear
pathways
brain.
These
unique
properties
hold
potential
be
utilized
addressing
symptoms
trauma
those
refractory
or
treatment-resistant
PTSD.
Historically,
federal
state
laws
restricted
research
into
how
can
used
treat
mental
illness
due
widespread
belief
these
present
more
harm
than
benefit.
However,
current
shift
public
opinion
on
psychedelics
has
propelled
look
benefits
patients
illness.
This
article
aims
discuss
mechanisms
work
brain,
well
beneficial
treatment.
Neuropsychopharmacology Reports,
Год журнала:
2024,
Номер
44(1), С. 292 - 297
Опубликована: Фев. 6, 2024
Abstract
Aim
Psychedelics
have
recently
gained
attention
as
potential
therapeutic
agents
for
various
psychiatric
disorders.
Previous
research
has
highlighted
that
a
diminished
sense
of
self,
commonly
termed
“ego‐dissolution”
is
pivotal
feature
the
psychedelic‐induced
state.
While
Ego‐Dissolution
Inventory
(EDI)
widely
acknowledged
instrument
measuring
this
phenomenon,
no
Japanese
version
been
available.
This
study
aimed
to
develop
EDI.
Methods
We
adhered
“Guidelines
Best
Practices
in
Translation
and
Cultural
Modification
Process
Patient‐Reported
Outcomes
Instruments:
Document
from
ISPOR
Committee
on
Modification”
during
our
translation
approach.
Two
psychiatrists
independently
conducted
initial
translations,
consolidated
was
achieved
via
mutual
agreement.
then
back‐translated
English
assessed
by
original
authors
consistency.
The
repetitive
modification
process
continuous
dialogues
with
until
they
accepted
concluding
version.
Results
finalized,
approved
EDI
presented
accompanying
figure.
In
addition,
authorized
included
Appendix.
Conclusions
study,
we
successfully
developed
will
assist
assessing
ego‐dissolution
experiences
associated
psychedelic‐assisted
therapy
among
speakers.
Additional
studies
are
necessary
evaluate
reliability
validity
newly
translated
instrument.
Journal of Psychopharmacology,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 3, 2024
Posttraumatic
stress
disorder
(PTSD)
is
a
condition
that
can
develop
after
traumatic
event,
causing
distressing
symptoms,
including
intrusive
re-experiencing
alterations
in
mood
and
cognition,
changes
arousal
reactivity.
Few
treatment
options
exist
for
patients
who
find
conventional
psychotherapy
pharmacotherapy
to
be
inaccessible,
ineffective,
or
intolerable.
We
explore
psilocybin
as
potential
option
PTSD
by
examining
the
neurobiology
of
well
psilocybin’s
mechanism
action.
Based
on
both
pharmacodynamic
psychoanalytic
principles,
may
an
underexplored
with
PTSD,
though
further
research
required.
