The Role of Concomitant Nrf2 Targeting and Stem Cell Therapy in Cerebrovascular Disease

Antioxidants, Год журнала: 2022, Номер 11(8), С. 1447 - 1447

Опубликована: Июль 26, 2022

Despite the reality that a death from cerebrovascular accident occurs every 3.5 min in United States, there are few therapeutic options which typically limited to narrow window of opportunity time for damage mitigation and recovery. Novel therapies have targeted pathological processes secondary initial insult, such as oxidative peripheral inflammation. One greatest challenges therapy is frequently permanent within CNS, attributed lack sufficient neurogenesis. Thus, recent use cell-based stroke shown promising results. Unfortunately, stroke-induced inflammatory limit potential these stem cells. Nuclear factor erythroid 2-related 2 (Nrf2) has been implicated endogenous antioxidant anti-inflammatory activity, thus presenting an attractive target novel therapeutics enhance cell promote This review assesses current literature on concomitant Nrf2 targeting via pharmaceutical natural agents, highlighting need elucidate both upstream downstream pathways optimizing treatments setting disease.

Язык: Английский

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The influence of diet on glycaemic control, sleep, and cognition

Опубликована: Фев. 24, 2024

The overarching aim of this thesis was to examine the impact diet on glycaemic control, cognition, and sleep using three different approaches. In Chapter 2, a systematic review effect load acute cognition in children, adolescents, adults conducted. A meta-analysis 15 studies revealed that breakfast influenced by timing testing, sample age, glucose tolerance, cognitive subdomain. Relative high load, low associated with significantly better immediate episodic memory during late postprandial period (>120 minutes). beneficial greater younger those tolerance. No differences working attention were revealed. 16 involving children adolescents suggested may prevent decline accuracy period. remaining five administered meals or drinks differing after time, two which reported lunch benefitted performance. However, conclusions cannot be made given paucity studies.In 3, effects consuming HGL drink LGL fifteen minutes before bedtime sleep, sleep-dependent consolidation, nocturnal metabolism examined young, healthy males (n = 20). There tentative evidence measures architecture continuity affected consumption GL shortly bedtime. most either non-significant trends no longer significant controlling for multiple comparisons, reflect lack statistical power, removal several outliers, conservative nature Bonferroni correction.In 4, chronic cinnamon turmeric/curcumin months apparently middle-aged older 28). Primary outcome included control secondary lipid profiles, c-reactive protein, mood, satiety, thirst, body mass index, fat percentage. any these between placebo group active one, two, supplementation. It is likely heterogeneity played key role absence effects.A series guiding principles created drawing from strengths limitations conducted as part past research. These outline some factors should considered when designing studies. goal facilitate understanding complex relationship blood levels, future.

Язык: Английский

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Genipin crosslinked hydrogels for food and biomedical applications: A scientometric review

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 282, С. 137478 - 137478

Опубликована: Ноя. 12, 2024

Язык: Английский

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Promoting remyelination in central nervous system diseases: potentials and prospects of natural products and herbal medicine

Pharmacological Research, Год журнала: 2024, Номер unknown, С. 107533 - 107533

Опубликована: Ноя. 1, 2024

Язык: Английский

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