Metabolic-Associated Fatty Liver Disease: The Influence of Oxidative Stress, Inflammation, Mitochondrial Dysfunctions, and the Role of Polyphenols

Pharmaceuticals, Год журнала: 2024, Номер 17(10), С. 1354 - 1354

Опубликована: Окт. 10, 2024

Metabolic-Associated Fatty Liver Disease (MAFLD) is a clinical-pathological scenario that occurs due to the accumulation of triglycerides in hepatocytes which considered significant cause liver conditions and contributes an increased risk death worldwide. Even though possible causes MAFLD can involve interaction genetics, hormones, nutrition, lifestyle (diet sedentary lifestyle) most influential factor developing this condition. Polyphenols comprise many natural chemical compounds be helpful managing metabolic diseases. Therefore, aim review was investigate impact oxidative stress, inflammation, mitochondrial dysfunction, role polyphenols MAFLD. Some reverse part damage related or among them are anthocyanin, baicalin, catechin, curcumin, chlorogenic acid, didymin, epigallocatechin-3-gallate, luteolin, mangiferin, puerarin, punicalagin, resveratrol, silymarin. These have actions reducing plasma enzymes, body mass index, waist circumference, adipose visceral indices, lipids, glycated hemoglobin, insulin resistance, HOMA index. They also reduce nuclear factor-KB (NF-KB), interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), blood pressure, fat content, steatosis fibrosis. On other hand, they improve HDL-c, adiponectin levels, fibrogenesis markers. results show promising prevention treatment

Язык: Английский

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Molecular Mechanisms Underlying Neuroinflammation Intervention with Medicinal Plants: A Critical and Narrative Review of the Current Literature

Pharmaceuticals, Год журнала: 2025, Номер 18(1), С. 133 - 133

Опубликована: Янв. 20, 2025

Neuroinflammation is a key factor in the progression of neurodegenerative diseases, driven by dysregulation molecular pathways and activation brain’s immune system, resulting release pro-inflammatory oxidative molecules. This chronic inflammation exacerbated peripheral leukocyte infiltration into central nervous system. Medicinal plants, with their historical use traditional medicine, have emerged as promising candidates to mitigate neuroinflammation offer sustainable alternative for addressing conditions green healthcare framework. review evaluates effects medicinal plants on neuroinflammation, emphasizing mechanisms action, effective dosages, clinical implications, based systematic search databases such PubMed, SCOPUS, Web Science. The findings highlight that like Cleistocalyx nervosum var. paniala, Curcuma longa, Cannabis sativa, Dioscorea nipponica reduce cytokines (TNF-α, IL-6, IL-1β), inhibit enzymes (COX-2 iNOS), activate antioxidant pathways, particularly Nrf2. NF-κB primary pathway inhibited across studies. While anti-inflammatory potential these significant, variability dosages phytochemical compositions limits translation. Here, we are modulators underscoring therapeutic potential. Future research should focus animal models, standardized protocols, safety assessments, integrating advanced methodologies, genetic studies nanotechnology, enhance applicability disease management.

Язык: Английский

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The health benefits of fermented fruits and vegetables and their underlying mechanisms

Comprehensive Reviews in Food Science and Food Safety, Год журнала: 2024, Номер 23(6)

Опубликована: Ноя. 1, 2024

Abstract Fermented fruits and vegetables are rich in phenolic compounds, minerals, vitamins, which have potential health benefits for the prevention of many diseases such as cardiovascular disease Type 2 diabetes. There is a growing demand development nondairy probiotic products based on view changing lifestyles (e.g., vegetarianism, veganism, allergy to dairy products) rise nutritional diet therapy. In this review, processes fermented described. The study focuses role bacteria fungi vegetables, outlines process transformation bioactive components, systematically summarizes possible mechanisms antioxidant, anti‐inflammatory, blood pressure‐lowering effects. effects depend mainly microorganisms present fermentation components they produce, phenols, organic acids. These active compounds exert anti‐obesity, hypotensive, hypoglycemic, other benefits. Therefore, foods can be promising way adapt market reduce wastage agriculturally produced vegetables.

Язык: Английский

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Detection of Peak Intensity Using an Integrated Optical Modeling Method for Identifying Defective Apple Leaves

Опубликована: Ноя. 26, 2024

Язык: Английский

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