Biomedicines,
Год журнала:
2025,
Номер
13(4), С. 858 - 858
Опубликована: Апрель 2, 2025
Background/Objectives:
Patients
with
central
nervous
system
injuries
who
are
hospitalized
in
intensive
care
units
(ICUs)
at
high
risk
for
nosocomial
infections.
Limited
data
available
on
the
incidence
and
patterns
of
microbial
colonization
infection
this
patient
population.
Methods:
To
fill
gap,
we
performed
an
electronic
health
record-based
study
1614
chronic
patients
brain
injury
admitted
to
ICU
from
2017
2023.
Results:
Among
infectious
complications,
pneumonia
was
most
common
(n
=
879;
54.46%).
Sepsis
diagnosed
54
patients,
whom
46
(85%)
were
pneumonia.
The
only
pathogen
that
showed
association
development
sepsis
colonized
Pseudomonas
aeruginosa
(pneumonia:
p
7.2
×
10−9;
sepsis:
1.7
10−5).
Bacterial
isolates
without
did
not
differ
titer
or
dynamics,
but
monomicrobial
culture
more
likely
develop
than
polymicrobial
(1
vs.
2
pathogens,
0.014;
1
+
pathogens
3
4
2.8
10−6),
although
lower
monoculture
polyculture.
all
sites
levels
multidrug
resistance
(Gram-negative
bacteria:
88–100%;
Gram-positive
48–97%),
no
differences
multidrug-resistant
organism
(MDRO)
rates.
Conclusions:
Our
results
highlight
burden
MDROs
neurological
ICUs
provide
novel
ecosystem-based
insights
into
mono-
development.
These
findings
may
be
useful
developing
strategies
protect
against
Frontiers in Bioscience-Elite,
Год журнала:
2024,
Номер
16(4)
Опубликована: Дек. 3, 2024
Since
infections
associated
with
microbial
communities
threaten
human
health,
research
is
increasingly
focusing
on
the
development
of
biofilms
and
strategies
to
combat
them.
Bacterial
may
include
bacteria
one
or
several
species.
Therefore,
examining
all
microbes
identifying
individual
community
responsible
for
infectious
process
important.
Rapid
accurate
detection
bacterial
pathogens
paramount
in
healthcare,
food
safety,
environmental
monitoring.
Here,
we
analyze
biofilm
composition
describe
main
groups
whose
presence
a
leads
infection
(Staphylococcus
aureus,
Enterococcus
spp.,
Cutibacterium
HACEK,
etc.).
Particular
attention
paid
that
can
lead
device-associated
infections,
damage,
disruption
normal
functioning
medical
devices,
such
as
cardiovascular
implants,
biliary
stents,
neurological,
orthopedic,
urological
penile
etc.
Special
consideration
given
tissue-located
oral
cavity,
lungs
lower
respiratory
tract,
upper
middle
ear,
system,
skeletal
wound
surface,
urogenital
system.
We
also
methods
used
biofilms,
microbiologically
testing,
staining,
microcolony
formation,
cellular
extracellular
components,
other
methods.
Finally,
present
ways
reduce
incidence
biofilm-caused
infections.
Pathogens,
Год журнала:
2025,
Номер
14(2), С. 163 - 163
Опубликована: Фев. 7, 2025
Quorum
sensing
(QS)
is
a
molecular
communication
mechanism
among
bacterial
cells.
It
critical
in
regulating
virulence
factors,
motility,
antibiotic
resistance,
and
biofilm
formation.
Pseudomonas
aeruginosa
Gram-negative
opportunistic
pathogen
linked
to
healthcare-associated
infections,
food
poisoning,
Treating
infections
caused
by
pathogenic
bacteria
has
become
challenge
due
the
development
of
multi-antibiotic
resistance
upon
continuous
exposure
antibiotics.
An
alternative
strategy
conventional
antimicrobials
decrease
pathogenicity
QS
inhibition,
also
known
as
quorum
quenching.
Using
plant-derived
compounds
an
environmentally
friendly
block
inhibit
growth.
Portulaca
oleracea
popular
plant
different
countries
used
traditional
medicine.
widely
consumed
raw
salads
garnishes,
though
it
can
be
cooked
vegetarian
dish.
This
study
evaluates
antimicrobial
activity
methanolic
extract
P.
its
effectiveness
blocking
or
attenuating
aeruginosa.
The
agar
well
diffusion
method
for
screening
antibacterial
showed
significant
growth
inhibition
at
500
mg/mL
with
minimum
inhibitory
concentration
31.25
mg/mL.
A
bioindicator
bacterium,
Chromobacterium
violaceum
CV026,
was
determine
effect
on
results
indicated
reduction
formation,
pyocyanin
production,
LasA
staphylolytic
activity.
phytochemical
analysis
Gas
Chromatography–Mass
Spectrometry
that
contained
several
phenols,
alkaloids,
esters,
other
previously
reported
have
antioxidant
effects.
These
findings
highlight
factors
suggests
important
source
natural
use
would
beneficial
pharmaceutical
applications.
Biomedicines,
Год журнала:
2025,
Номер
13(4), С. 858 - 858
Опубликована: Апрель 2, 2025
Background/Objectives:
Patients
with
central
nervous
system
injuries
who
are
hospitalized
in
intensive
care
units
(ICUs)
at
high
risk
for
nosocomial
infections.
Limited
data
available
on
the
incidence
and
patterns
of
microbial
colonization
infection
this
patient
population.
Methods:
To
fill
gap,
we
performed
an
electronic
health
record-based
study
1614
chronic
patients
brain
injury
admitted
to
ICU
from
2017
2023.
Results:
Among
infectious
complications,
pneumonia
was
most
common
(n
=
879;
54.46%).
Sepsis
diagnosed
54
patients,
whom
46
(85%)
were
pneumonia.
The
only
pathogen
that
showed
association
development
sepsis
colonized
Pseudomonas
aeruginosa
(pneumonia:
p
7.2
×
10−9;
sepsis:
1.7
10−5).
Bacterial
isolates
without
did
not
differ
titer
or
dynamics,
but
monomicrobial
culture
more
likely
develop
than
polymicrobial
(1
vs.
2
pathogens,
0.014;
1
+
pathogens
3
4
2.8
10−6),
although
lower
monoculture
polyculture.
all
sites
levels
multidrug
resistance
(Gram-negative
bacteria:
88–100%;
Gram-positive
48–97%),
no
differences
multidrug-resistant
organism
(MDRO)
rates.
Conclusions:
Our
results
highlight
burden
MDROs
neurological
ICUs
provide
novel
ecosystem-based
insights
into
mono-
development.
These
findings
may
be
useful
developing
strategies
protect
against
