The Effects of Heat Stress on the Ovary, Follicles and Oocytes: A Systematic Review DOI Creative Commons
Luhan T. Zhou, Dilan Gokyer, Krystal Madkins

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Дек. 5, 2024

Climate change is driving significant environmental changes with profound implications for human health, including fertility. While the detrimental effects of heat on spermatogenesis are well-documented, impact elevated temperatures ovaries and female fertility remains less explored. This review systematically examines literature stress (HS) mammalian ovaries, follicles, oocytes. Evidence from models indicates that HS significantly impairs ovarian function, disrupting hormone profiles, reducing size weight, altering histology, decreasing granulosa cell viability, compromising oocyte quality. Efforts to develop strategies substances mitigate these adverse ongoing, but further research into underlying mechanisms urgently needed.

Язык: Английский

Single-cell profiling reveals transcriptome dynamics during bovine oocyte growth DOI Creative Commons

Lais Barbosa Latorraca,

António Galvão, María Belén Rabaglino

и другие.

BMC Genomics, Год журнала: 2024, Номер 25(1)

Опубликована: Апрель 5, 2024

Mammalian follicle development is characterized by extensive changes in morphology, endocrine responsiveness, and function, providing the optimum environment for oocyte growth, development, resumption of meiosis. In cattle, first signs transcription activation are observed secondary follicle, later than during mouse human oogenesis. While many studies have generated datasets characterizing gene expression bovine oocytes, they mostly limited to analysis fully grown matured oocytes. The aim present study was apply single-cell RNA sequencing interrogate transcriptome growing from stage through mid-antral stage.

Язык: Английский

Процитировано

7
Genetic parameters and genome-wide association studies including the X chromosome for various reproduction and semen quality traits in Nellore cattle DOI Creative Commons

Felipe E. de Carvalho,

José Bento Sterman Ferraz, Victor Breno Pedrosa

и другие.

BMC Genomics, Год журнала: 2025, Номер 26(1)

Опубликована: Янв. 10, 2025

Abstract Background The profitability of the beef industry is directly influenced by fertility rate and reproductive performance both males females, which can be improved through selective breeding. When performing genomic analyses, genetic markers located on X chromosome have been commonly ignored despite being one largest chromosomes in cattle genome. Therefore, primary objectives this study were to: (1) estimate variance components parameters for eighteen male five female traits Nellore including analyses; (2) perform genome-wide association studies functional analyses to better understand background cattle. Results percentage total direct heritability (h 2 ) explained x ranged from 3 32% (average: 16.4%) 9 67% 25.61%) traits, respectively. Among related breeding soundness evaluation, overall bull semen evaluation quality accounted highest proportion h relative with an average 39.5% 38.75%, number significant per trait 7 (seminal vesicle width) 43 (total major defects). zero five. A 683, 252, 694, 382, 61, 77 genes overlapped regions identified performance, quality, morphology, defects, bulls’ key candidate are PRR32 , STK26 TMSB4X TLR7 PRPS2 SMS SMARCA1 UTP14A BCORL1 . main gene ontology terms “Oocyte Meiosis”, “Progesterone Mediated Oocyte Maturation”, “Thermogenesis”, “Sperm Flagellum”, “Innate Immune Response”. Conclusions Our findings indicate role phenotypic variability reproduction Breeding programs aiming improve these should consider adding information their analyses.

Язык: Английский

Процитировано

0
Identification of selection signatures and genetic diversity in the sheep DOI Creative Commons
Mustafa Karabaş, Onur Yılmaz

Tropical Animal Health and Production, Год журнала: 2025, Номер 57(2)

Опубликована: Фев. 18, 2025

Abstract In the study, data obtained from OvineSNP50K SNP chips using Illumina® iScan platform for Eşme sheep were used. The integrated haplotype score (iHS) and runs of homozygosity (ROH) statistical approaches used to identify selection signatures. Using iHS analysis, it was discovered that there are 10 genomic regions 51 genes on ovine chromosomes 1, 9, 11, 12 under selection. Three 97 6 11 found be ROH analysis. Candidate associated with economic ecological traits detected both approaches. Among genetic diversity parameters considered in this minor allele frequency (MAF), distance between individuals (D), as well observed (Ho) expected heterozygosities (He) values 0.300, 0.309, 0.388, 0.390, respectively. Ho, He D indicate a moderate level diversity. ratio polymorphic SNPs (PN) 0.947, average F HOM 0.030 0.029, Considering PN value is evident population exhibit high polymorphism at 94.7%. While indicates among present suggests predominantly composed heterozygous individuals. As result, evidence indicating advancements have been made target breeding programs within population. Additionally, candidate suitable future molecular marker-supported identified. addition, better understanding structure production potential has achieved. Findings shown breed meat strong adaptation abilities.

Язык: Английский

Процитировано

0
Identification of Selection Signatures and Genetic Diversity in the Sheep DOI Creative Commons
Mustafa Karabaş, Onur Yılmaz

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Янв. 8, 2024

Abstract The study utilized genome-wide data from the Illumina OvineSNP50K platform and specifically targeted Eşme sheep population. integrated haplotype score (iHS) runs of homozygosity (ROH) statistical approaches were used to identify selection signatures. Using iHS analysis, it was discovered that there are 10 genomic regions 51 genes on chromosomes 1, 9, 11, 12 under selection. Three 97 6 11 found be using ROH analysis. Candidate associated with economic ecological traits detected both approaches. Among genetic diversity parameters considered in study, minor allele frequency (MAF), distance between individuals (D), observed heterozygosity (Ho), expected (He) values 0.300, 0.309, 0.388, 0.390, respectively. ratio polymorphic SNPs (PN) 0.947, average FROH FHOM 0.030 0.029, demonstrates signature can define characteristics farm animals phenotypic information. information obtained through these breeding conservation programs for resources animals.

Язык: Английский

Процитировано

2
Comprehensive time-course gene expression evaluation of high-risk beef cattle to establish immunological characteristics associated with undifferentiated bovine respiratory disease DOI Creative Commons
Matthew A. Scott, Robert Valeris-Chacín, Alexis C. Thompson

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Сен. 13, 2024

Bovine respiratory disease (BRD) remains the leading infectious in beef cattle production systems. Host gene expression upon facility arrival may indicate risk of BRD development and severity. However, a time-course approach would better define how influences immunological inflammatory responses after occurrences. Here, we evaluated whole blood transcriptomes high-risk at three time points to elucidate BRD-associated host response. Sequenced jugular mRNA from 36 (2015:

Язык: Английский

Процитировано

0
Applications of Next-Generation Sequencing Technologies and Statistical Tools in Identifying Pathways and Biomarkers for Heat Tolerance in Livestock DOI Creative Commons
Gajendirane Kalaignazhal, Veerasamy Sejian, M. V. Silpa

и другие.

Veterinary Sciences, Год журнала: 2024, Номер 11(12), С. 616 - 616

Опубликована: Дек. 2, 2024

The climate change-associated abnormal weather patterns negatively influences the productivity and performance of farm animals. Heat stress is major detrimental factor hampering production, causing substantial economic loss to livestock industry. Therefore, it important identify heat-tolerant breeds that can survive produce optimally in any given environment. To achieve this goal, a clearer understanding genetic differences underlying molecular mechanisms associated with change impacts heat tolerance are prerequisite. Adopting next-generation biotechnological statistical tools like whole transcriptome analysis, metagenome sequencing, bisulphite genome-wide association studies (GWAS), selection signatures provides an opportunity goal. Through these techniques, possible permanent markers for tolerance, by incorporating those marker-assisted breeding selection, target livestock. This review gives overview recent advancements assessing using such ‘omics’ approaches models. salient findings from research highlighted several candidate biomarkers have potential be incorporated into future heat-tolerance studies. Such could revolutionise production changing scenario support food demands growing human population.

Язык: Английский

Процитировано

0
The Effects of Heat Stress on the Ovary, Follicles and Oocytes: A Systematic Review DOI Creative Commons
Luhan T. Zhou, Dilan Gokyer, Krystal Madkins

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Дек. 5, 2024

Climate change is driving significant environmental changes with profound implications for human health, including fertility. While the detrimental effects of heat on spermatogenesis are well-documented, impact elevated temperatures ovaries and female fertility remains less explored. This review systematically examines literature stress (HS) mammalian ovaries, follicles, oocytes. Evidence from models indicates that HS significantly impairs ovarian function, disrupting hormone profiles, reducing size weight, altering histology, decreasing granulosa cell viability, compromising oocyte quality. Efforts to develop strategies substances mitigate these adverse ongoing, but further research into underlying mechanisms urgently needed.

Язык: Английский

Процитировано

0