Journal of Macromolecular Science Part A, Год журнала: 2024, Номер 61(9), С. 675 - 690
Опубликована: Авг. 24, 2024
In this study, hydrogels were synthesized using Prunus persica ev. Bayramiç Beyazı extract as a crosslinker. N-3-(Dimethylamino)propyl methacrylamide (DMAPMA) and 2-Hydroxyethyl methacrylate (HEMA) monomers used in by redox polymerization. Hydrogel@Ag composites created synthesizing Ag0 nanoparticles within hydrogel network structures cross-linked with plant an in-situ green synthesis method. These characterized swelling, FTIR, TEM, XRD, TGA methods. The hydrogel@Ag loaded Naproxen Cefazolin drugs. in-vitro drug release profiles of the examined pH = 5.5 PBS environment, it was determined that approximately 75% drugs released 5 h. kinetics model for Higuchi model, followed Korsmeyer-Peppas model. nanoparticle encapsulation significantly affected degree swelling. MBA showed swelling capacity 370.16% mass, while fruit exhibited 1000.78% mass. silver-encapsulated demonstrated even higher 2313% Additionally, antibacterial tests against Staphylococcus aureus, Pseudomonas aeruginosa, Enterococcus faecalis microorganisms, Ag-free did not exhibit activity.
Язык: Английский