iScience,
Год журнала:
2023,
Номер
26(12), С. 108454 - 108454
Опубликована: Ноя. 14, 2023
Understanding
the
pathways
of
human
exposure
to
micro(nano)plastics
(MNPs)
is
crucial
for
assessing
their
health
impacts.
Intravenous
infusion
can
induce
MNPs
direct
entry
into
blood,
posing
serious
risks
on
health,
but
remains
unclear.
Herein,
we
developed
comprehensive
analytical
methods
detect
polyvinyl
chloride
(PVC)
down
20
nm,
and
found
about
0.52
μg
equal
105-1011
particles
PVC-MNPs
released
from
intravenous
products
(IVIPs)
during
each
250
mL
injection.
The
amounts
IVIPs
were
dependent
plastic
materials,
injection
volume
composition.
These
findings
indicated
that
should
be
directly
introduced
blood
circulatory
system,
causing
impacts
health.
Our
study
reveals
a
previously
ignored
important
pathway
MNPs,
calls
further
research
potential
these
Environment International,
Год журнала:
2024,
Номер
186, С. 108617 - 108617
Опубликована: Март 30, 2024
Microplastics
(MPs)
and
nanoplastics
(NPs)
pollution
has
emerged
as
a
significant
widespread
environmental
issue.
Humans
are
inevitably
exposed
to
MPs
NPs
via
ingestion,
inhalation,
dermal
contacts
from
various
sources.
However,
mechanistic
knowledge
of
their
distribution,
interaction,
potency
in
the
body
is
still
lacking.
To
address
this
gap,
we
have
undertaken
task
elucidating
toxicokinetic
(TK)
behaviors
NPs,
aiming
provide
information
for
constructing
conceptual
physiologically
based
(PBTK)
model
support
silico
modeling
approaches.
Our
effort
involved
thorough
examination
existing
literature
data
collation
on
presence
human
vitro/ex
vivo/in
vivo
biodistribution
across
cells
tissues.
By
comprehending
absorption,
metabolism,
excretion
mechanisms
relation
physicochemical
attributes,
established
foundational
understanding
link
between
external
exposure
internal
tissue
dosimetry.
We
observed
that
particle
size
surface
chemistry
been
thoroughly
explored
previous
experimental
studies.
certain
such
polymer
type,
shape,
biofilm/biocorona,
warrant
attention
further
examination.
discussed
fundamental
disparities
TK
properties
MPs/NPs
those
engineered
nanoparticles.
proposed
preliminary
PBTK
framework
with
several
possible
approaches
challenges
investigation.
Overall,
article
provides
comprehensive
compilation
MPs/NPs,
critical
overview
processes
mechanisms,
proposes
potential
approaches,
particularly
regarding
applicability
system,
outlines
future
perspectives
developing
models
integration
into
health
risk
assessment
NPs.
Microplastics,
as
an
emerging
environmental
pollutant,
have
received
widespread
attention
for
their
potential
impact
on
ecosystems
and
human
health.
Microplastics
are
defined
plastic
particles
less
than
5
millimeters
in
diameter
can
be
categorized
primary
secondary
microplastics.
Primary
microplastics
usually
originate
directly
from
industrial
production,
while
formed
by
the
degradation
of
larger
items.
capable
triggering
cytotoxicity
chronic
inflammation,
may
promote
cancer
through
mechanisms
such
pro-inflammatory
responses,
oxidative
stress
endocrine
disruption.
In
addition,
improved
bring
new
perspectives
to
therapy,
studies
drug
carriers
underway,
showing
high
targeting
bioavailability.
Although
current
suggest
association
between
certain
cancers
(e.g.,
lung,
liver,
breast
cancers),
long-term
effects
specific
still
need
studied.
This
review
aimed
at
exploring
carcinogenicity
promising
applications
therapy
provides
important
directions
future
research
emphasizes
multidisciplinary
collaboration
address
this
global
health
challenge.
Journal of Hazardous Materials,
Год журнала:
2025,
Номер
unknown, С. 137795 - 137795
Опубликована: Март 1, 2025
Microplastics
(MPs)
and
nanoplastics
(NPs)
represent
an
emerging
issue
for
human
animal
health.
This
review
critically
examines
in
vitro
vivo
studies
to
elucidate
their
mechanisms
of
action
toxicological
effects.
Key
objectives
included:
providing
a
comprehensive
overview
MP-NPs
literature,
assessing
experimental
conditions
relative
real
environmental
scenarios,
identifying
pathways
at
the
molecular
level.
The
findings
revealed
significant
progress
understanding
impacts.
In
particular,
it
has
been
observed
promotion
inflammation,
oxidative
stress,
apoptosis,
autophagy,
endoplasmic
reticulum
(ER)
stress
via
specific
signaling
axes.
Reproductive
toxicity
emerged
as
primary
research
focus,
particularly
male
models,
whereas
effects
on
gastrointestinal,
neurological,
cardiovascular
systems
were
insufficiently
studied,
especially
affected.
Most
disproportionately
focused
polystyrene
particles,
neglecting
other
prevalent
polymers
such
polyethylene
polypropylene.
Furthermore,
reliance
synthetic
microspheres
non-realistic
concentrations
limits
relevance
real-world
conditions.
Limited
long-term
exposure
further
constrain
persistence
risks.
view
this,
future
should
integrate
environmentally
relevant
particles
doses,
size
composition,
assessments,
advanced
methodologies
omics
computational
modeling.
addition,
therapeutic
interventions
targeting
ER
inflammation
apoptosis
may
be
excellent
solution
mitigate
toxicity.
At
same
time,
standardized
global
approach
is
needed
fully
understand
risks
posed
by
MP-NPs,
attempting
safeguard
public
iScience,
Год журнала:
2023,
Номер
26(12), С. 108454 - 108454
Опубликована: Ноя. 14, 2023
Understanding
the
pathways
of
human
exposure
to
micro(nano)plastics
(MNPs)
is
crucial
for
assessing
their
health
impacts.
Intravenous
infusion
can
induce
MNPs
direct
entry
into
blood,
posing
serious
risks
on
health,
but
remains
unclear.
Herein,
we
developed
comprehensive
analytical
methods
detect
polyvinyl
chloride
(PVC)
down
20
nm,
and
found
about
0.52
μg
equal
105-1011
particles
PVC-MNPs
released
from
intravenous
products
(IVIPs)
during
each
250
mL
injection.
The
amounts
IVIPs
were
dependent
plastic
materials,
injection
volume
composition.
These
findings
indicated
that
should
be
directly
introduced
blood
circulatory
system,
causing
impacts
health.
Our
study
reveals
a
previously
ignored
important
pathway
MNPs,
calls
further
research
potential
these
