2-Aminobenzothiazoles in anticancer drug design and discovery

Bioorganic Chemistry, Год журнала: 2023, Номер 135, С. 106477 - 106477

Опубликована: Март 20, 2023

Язык: Английский

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Recent Studies of Nitrogen and Sulfur Containing Heterocyclic Analogues as Novel Antidiabetic Agents: A Review

Chemistry & Biodiversity, Год журнала: 2023, Номер 21(2)

Опубликована: Дек. 21, 2023

The prevalence of diabetes mellitus is on the rise, which demands identification novel antidiabetic drugs. There a need for safer and more effective alternatives because therapy methods now available to manage have limits. Due their diverse pharmacological characteristics, heterocyclic molecules with nitrogen Sulfur atoms become intriguing candidates in medicinal chemistry. These substances wide variety structures that can be customized target different pathways associated affect important biological targets involved glucose homeostasis. This review provides thorough summary most recent studies analogues as prospective agents. examines structural forms, action, assesses results preclinical clinical investigations effectiveness safety. Additionally, further optimization development innovative medications are highlighted, well difficulties prospects future utilizing therapeutic potential these analogues. study seeks stimulate additional investigation cooperation between researchers chemists, promoting improvements creation efficient secure medicines fulfill needs management diabetes.

Язык: Английский

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Benzothiazole a privileged scaffold for Cutting-Edges anticancer agents: Exploring drug design, structure-activity relationship, and docking studies

European Journal of Medicinal Chemistry, Год журнала: 2024, Номер 279, С. 116831 - 116831

Опубликована: Сен. 6, 2024

Язык: Английский

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A β-ketoenamine-linked covalent organic framework as a heterogeneous photocatalyst for the synthesis of 2-arylbenzothiazoles by cyclization reaction

Green Chemistry, Год журнала: 2023, Номер 25(13), С. 5195 - 5205

Опубликована: Янв. 1, 2023

A series of 2-arylbenzothiazoles and their derivatives were prepared in high yields by visible light-induced intramolecular cyclization under mild conditions using TAPT-TP-COF as a photocatalyst.

Язык: Английский

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Assessment of the Inhibitory Efficacy of a Thiazole Derivative as an Efficient Corrosion Inhibitor for Augmenting the Resistance of MS in Acidic Environments

Langmuir, Год журнала: 2024, Номер 40(31), С. 16367 - 16383

Опубликована: Июль 26, 2024

Numerous thiazole compounds have been developed as cutting-edge inhibitors because of a rising fascination with using corrosion (CIs) and preventative measures to prevent mild steel (MS) from deteriorating. In this study, the ability novel derivative, 2-hydrazono-3-methyl-2,3-dihydrobenzo[d]thiazole hydrochloride (HMDBT), MS in HCl has reconnoitered various approaches, Viz. gravimetric analysis, electrochemical (EC) different surface characterizations. With an inhibition efficiency (IE %) 95.35%, outcomes elucidate that HMDBT functions potent CI is environmentally friendly sustainable. The computed activation thermodynamic factors were also employed better explain process underpinning inhibiting tendency HMDBT. According values, molecules physically chemically adhered following Langmuir model, generating dense protective layer may be associated presence benzene ring heteroatoms (S & N) architecture. Based on findings EIS studies, intensification CI's concentration (50 →800) ppm ushered by increases polarization resistance (Rp) (80.72, 354.31) Ω cm2, attenuation double-layer capacitance (Cdl) (198.78 → 44.13) μF cm–2, respectively, confirming inhibitory proficiency IE inhibitor was reported around 95.35% weight loss measurement 89.94% through EC measurement. Theoretical analysis including density functional theory (DFT) molecular dynamics (MD) simulations carried out investigate additional effects anticorrosion effectiveness mechanism inhibition. theoretical parameters calculated provided important assistance comprehending moieties disclosed are strong concord experimental methods. To create "green" system, work presented here technique reduce adding new inhibitor.

Язык: Английский

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Design, Synthesis and Biological Activities of (Thio)Urea Benzothiazole Derivatives

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(11), С. 9488 - 9488

Опубликована: Май 30, 2023

(Thio)ureas ((T)Us) and benzothiazoles (BTs) each have demonstrated to a great variety of biological activities. When these groups come together, the 2-(thio)ureabenzothizoles [(T)UBTs] are formed, improving physicochemical as well properties, making compounds very interesting in medicinal chemistry. Frentizole, bentaluron methabenzthiazuron examples UBTs used for treatment rheumatoid arthritis wood preservatives herbicides winter corn crops, respectively. With this antecedent, we recently reported bibliographic review about synthesis class compounds, from reaction substituted 2-aminobenzothiazoles (ABTs) with iso(thio)cyanates, (thio)phosgenes, (thio)carbamoyl chlorides, 1,1’-(thio)carbonyldiimidazoles, carbon disulfide. Herein, prepared those features design, chemical synthesis, activities relating (T)UBTs potential therapeutic agents. This is synthetic methodologies generated 1968 present day, highlighting focus transform containing range substituents, illustrated 37 schemes 11 figures concluded 148 references. In topic, scientists dedicated chemistry pharmaceutical industry will find useful information design group aim repurposing compounds.

Язык: Английский

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An ROS-Responsive Donor That Self-Reports Its H₂S Delivery by Forming a Benzoxazole-Based Fluorophore

Journal of the American Chemical Society, Год журнала: 2023, Номер 145(46), С. 25486 - 25494

Опубликована: Ноя. 11, 2023

Hydrogen sulfide (H2S), an endogenous signaling molecule, is known to play a pivotal role in neuroprotection, vasodilation, and hormonal regulation. To further explore the biological effects of H2S, refined donors that facilitate its delivery, especially under specific (patho) physiological conditions, are needed. In present study, we demonstrate ortho-substituted, aryl boronate esters provide two unique distinct pathways for H2S release from thioamide-based donors: Lewis acid-facilitated hydrolysis reactive oxygen species (ROS)-induced oxidation/cyclization. Through detailed structure–activity relationship resist solely via latter mechanism were identified, which have added benefit providing potentially useful heterocycle as lone byproduct this novel chemistry. highlight this, developed ROS-activated donor (QH642) simultaneously synthesizes benzoxazole-based fluorophore en route delivery. A advantage design over earlier self-reporting formation possible only if has been discharged donor. This key feature eliminates potential false positives provides more accurate depiction reaction progress delivery including complex cellular environments.

Язык: Английский

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2-(Diarylalkyl)Aminobenzothiazole Derivatives Induce Autophagy And Apoptotic Death Through SIRT Inhibition And P53 Activation In MCF7 Breast Cancer Cells

Computational Biology and Chemistry, Год журнала: 2025, Номер 116, С. 108395 - 108395

Опубликована: Фев. 21, 2025

Язык: Английский

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Multifunctional Catalysis of Nanosheet Defective Molybdenum Sulfide Basal Planes for Tandem Reactions Involving Alcohols and Molecular Hydrogen

ACS Sustainable Chemistry & Engineering, Год журнала: 2023, Номер 11(33), С. 12265 - 12279

Опубликована: Авг. 9, 2023

Establishing tandem catalytic synthetic strategies based on the use of readily available, stable, and renewable feedstocks is great significant for sustainable advancement chemical-related industries. The key to success largely relies applying efficient multifunctional catalysts that allow carrying out one-pot single-step synthesis. In this work, we have demonstrated defect-engineered basal planes a molybdenum sulfide nanomaterial ({Mo3S4}n) offer platform chemical process intensification. By catalyst, besides borrowing hydrogen-type processes, herein exemplified thioetherification alcohols, also disclosed novel rare coupling reactions requiring hydrogen activation alcohol dehydrogenation processes in fashion. More specifically, oxidized nucleophiles, such as o-dinitroarenes dinitrophenyl disulfides, are reacted with alcohols presence H2 yield respectively benzimidazoles benzothiazoles. uncommon reactivity {Mo3S4}n arises from coordinatively unsaturated species, which work Lewis acid basic sites, respectively. As suggested by situ infrared (IR) spectroscopy investigations, involves participation both types active sites while dissociation takes place species.

Язык: Английский

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Advances in chalcone derivatives: Unravelling their anticancer potential through structure-activity studies

Journal of Molecular Structure, Год журнала: 2023, Номер 1299, С. 137154 - 137154

Опубликована: Ноя. 30, 2023

Язык: Английский

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