Tanshinone IIA ameliorates experimental diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress in cardiomyocytes via SIRT1

Phytotherapy Research, Год журнала: 2023, Номер 37(8), С. 3543 - 3558

Опубликована: Май 1, 2023

Abstract Diabetic cardiomyopathy (DCM) is a common complication in patients with diabetes, and ultimately leads to heart failure. Endoplasmic reticulum stress (ERS) induced by abnormal glycolipid metabolism critical factor that affects the occurrence development of DCM. Additionally, upregulation/activation silent information regulation 2 homolog‐1 (SIRT1) has been shown protect against Tanshinone II A (Tan IIA), main active component Salviae miltiorrhizae radix et rhizome (a valuable Chinese medicine), protective effects cardiovascular disease diabetes. However, its role mechanisms diabetes‐induced cardiac dysfunction remain unclear. Therefore, we explored whether Tan IIA alleviates ERS‐mediated DCM via SIRT1 elucidated underlying mechanism. The results suggested alleviated pathological changes hearts diabetic mice, ameliorated cytopathological morphology cardiomyocytes, reduced cell death rate, inhibited expression ERS‐related proteins mRNA. agonist activities glucose‐regulated protein 78 (GRP78). Furthermore, opposite under inhibitor. knockdown was siRNA‐SIRT1 transfection, degree GRP78 acetylation increased. Cumulatively, inhibiting ERS upregulating expression.

Язык: Английский

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Exploring the Significance of Gut Microbiota in Diabetes Pathogenesis and Management—A Narrative Review

Nutrients, Год журнала: 2024, Номер 16(12), С. 1938 - 1938

Опубликована: Июнь 19, 2024

Type 2 diabetes is a disease with significant health consequences for the individual. Currently, new mechanisms and therapeutic approaches that may affect this are being sought. One of them association type microbiota. Through enteric nervous system gut–microbiota axis, microbiota affects functioning body. It has been proven to have real impact on influencing glucose lipid metabolism insulin sensitivity. With dysbiosis, there increased bacterial translocation through disrupted intestinal barrier inflammation in In diabetes, microbiota’s composition altered with, example, more abundant class Betaproteobacteria. The these disorders linked involving short-chain fatty acids, branched-chain amino lipopolysaccharide, among others. Interventions focusing gut gaining traction as promising approach management. Studies currently conducted effects supply probiotics prebiotics, well fecal transplantation, course diabetes. Further research will allow us fully develop our knowledge subject possibly best treat prevent

Язык: Английский

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Sodium-Glucose Transporter-2 Inhibitors (SGLT2i) and Myocardial Ischemia: Another Compelling Reason to Consider These Agents Regardless of Diabetes

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 2103 - 2103

Опубликована: Фев. 27, 2025

In recent years, the introduction of sodium-glucose transporter-2 inhibitors (SGLT2is) marked a significant advancement in treatment cardiovascular disease (CVD). Beyond their known effects on glycemic control and lipid profile, SGLT2is demonstrate notable benefits for morbidity mortality, regardless diabetic status. These agents are currently recommended as first-line therapies patients with heart failure, both reduced preserved ejection fraction, they improve symptoms reduce risk hospitalization. While several studies have demonstrated that can incidence major adverse events (MACEs), true impact these atherosclerosis progression myocardial ischemia remains to be fully understood. A global beneficial effect related improved could hypothesized, even though substantial evidence shows direct molecular pathways enhance endothelial function, exhibit anti-inflammatory properties, provide protection. this context, narrative review summarizes current knowledge regarding novel anti-diabetic drugs preventing treating ischemia, aiming define an additional area application beyond failure.

Язык: Английский

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Protective effect of Astragaloside IV on chronic intermittent hypoxia-induced vascular endothelial dysfunction through the calpain-1/SIRT1/AMPK signaling pathway

Frontiers in Pharmacology, Год журнала: 2022, Номер 13

Опубликована: Авг. 2, 2022

Vascular endothelial dysfunction (VED) is linked with the pathogenesis of obstructive sleep apnea (OSA) comorbidities, such as cardiovascular disease. Astragaloside IV (As-IV) has exhibited significant improvement for dysfunction. Nonetheless, protective mechanism not clear. Therefore, present study investigated potential As-IV on VED. Calpain-1 knockout and wild-type C57BL/6 mice exposed to chronic intermittent hypoxia (CIH) were established treated (40, 80 mg/kg) 4 weeks. Human coronary artery cells (HCAECs) subjected CIH exposure pretreated As-IV, MDL-28170 (calpain-1 inhibitor) SRT1720 (SIRT1 activator) 48 h in vitro . The function, inflammation, oxidative stress mitochondrial function measured evaluate Our data revealed that treatment ameliorated CIH-induced endothelial-dependent vasomotion augmented nitric oxide (NO) production. administration suppressed secretion reduced expression calpain-1 restored downregulated SIRT1 Thr 172 AMPK Ser 1177 eNOS phosphorylation. effects similar effect These findings demonstrated VED induced by via calpain-1/SIRT1/AMPK signaling pathway.

Язык: Английский

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Protective Effects of Berberine on Nonalcoholic Fatty Liver Disease in db/db Mice via AMPK/SIRT1 Pathway Activation

Current Medical Science, Год журнала: 2024, Номер 44(5), С. 902 - 911

Опубликована: Июль 23, 2024

Язык: Английский

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Sirtuins Modulation: A Promising Strategy for HIV-Associated Neurocognitive Impairments

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(2), С. 643 - 643

Опубликована: Янв. 7, 2022

HIV-Associated neurocognitive disorder (HAND) is one of the major concerns since it persists in 40% this population. Nowadays, HAND neuropathogenesis considered to be caused by infected cells that cross brain–blood barrier and produce viral proteins can secreted internalized into neurons leading disruption cellular processes. The evidence points such as Tat causal agent for neuronal alteration thus HAND. hallmarks Tat-induced neurodegeneration are endoplasmic reticulum stress mitochondrial dysfunction. Sirtuins (SIRTs) NAD+-dependent deacetylases involved mitochondria biogenesis, unfolded protein response, intrinsic apoptosis pathway. interaction with these causes inhibition SIRT1 SIRT3. Studies revealed SIRTs activation promotes neuroprotection neurodegenerative diseases Alzheimer’s Parkinson’s disease. Therefore, review focuses on neurotoxicity mechanisms involve key regulators their modulation a therapeutic strategy tackling thereby improving quality life people living HIV.

Язык: Английский

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Sirtuins and Their Implications in the Physiopathology of Gestational Diabetes Mellitus

Pharmaceuticals, Год журнала: 2025, Номер 18(1), С. 41 - 41

Опубликована: Янв. 1, 2025

Gestational diabetes mellitus (GDM) imposes serious short- and long-term health problems for the mother her child. An effective therapeutic that can reduce incidence of GDM improve outcomes is a major research priority very important public health. Unfortunately, despite numerous studies, molecular mechanisms underlying are not fully defined require further study. Chronic low-grade inflammation, oxidative stress, insulin resistance central features pregnancies complicated by GDM. There evidence involvement sirtuins, which NAD+-dependent histone deacetylases, in energy metabolism inflammation. Taking these facts into consideration, role sirtuins pathomechanism will be discussed.

Язык: Английский

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Advances in the Regulation of Growth by SIRT1

Medical Diagnosis, Год журнала: 2025, Номер 15(01), С. 22 - 27

Опубликована: Янв. 1, 2025

Язык: Английский

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Association of SIRT1 rs3758391 Polymorphism With T2DM in Bangladeshi Population: Evidence From a Case‐Control Study and Meta‐Analysis

Health Science Reports, Год журнала: 2025, Номер 8(2)

Опубликована: Фев. 1, 2025

Type 2 diabetes mellitus (T2DM) remains one of the major causes morbidity and mortality worldwide, including Bangladesh. SIRT1, an NAD-dependent deacetylase, is involved in energy homeostasis protects β-cells pancreas from oxidative stress. Single nucleotide polymorphisms (SNPs) SIRT1 gene have been found to be associated with T2DM several populations, however, conflicting results. The aim this present case-control study, along meta-analysis, was elucidate association rs3758391 polymorphism susceptibility Bangladeshi population. 72 patients 90 healthy controls were enrolled our study polymerase chain reaction-restriction fragment length (PCR-RFLP) employed for genotyping SNP. Odds ratio (OR) 95% confidence interval (95% CI) used represent T2DM. For meta-analysis six studies included pooled odds CI calculated genetic models using random effects model. Heterogeneity publication bias also each study. A significant between increased risk under codominant TT versus CC (OR = 3.88, 1.34-11.25, p 0.012), recessive + CT 2.83, 1.12-7.09, 0.027) allelic T C 1.67, 1.07-2.60, 0.024) models. However, no other biochemical anthropometric parameters found. Our showed statistically polymorphism. We conclude that, at conferred

Язык: Английский

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Melatonin promotes diabetic wound healing by mediating mitochondrial function in endothelial cells through the AMPK/SIRT1/HIF-1α pathway

Tissue and Cell, Год журнала: 2025, Номер unknown, С. 102884 - 102884

Опубликована: Март 1, 2025

Язык: Английский

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