From Compression to Itch: Exploring the Link Between Nerve Compression and Neuropathic Pruritus
American Journal of Clinical Dermatology,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 17, 2024
Neuropathic
itch
is
a
type
of
chronic
pruritus
resulting
from
neural
dysfunction
along
the
afferent
pathway.
It
often
accompanied
by
abnormal
sensations
such
as
paresthesia,
hyperesthesia,
or
hypoesthesia.
This
condition,
which
may
involve
motor
autonomic
damage,
significantly
impacts
patients'
quality
life,
causing
severe
and
associated
comorbidities
depression,
disrupted
sleep,
social
strain.
accounts
for
8%
cases,
though
this
be
underestimated.
comprehensive
review
focuses
on
nerve
impingement
primary
pathophysiological
mechanism
various
forms
neuropathic
including
brachioradial
(BRP),
notalgia
paresthetica
(NP),
anogenital
itch.
BRP,
seen
in
middle-aged
white
women,
manifests
dorsolateral
forearms
typically
exacerbated
ultraviolet
(UV)
exposure
related
to
cervical
spine
pathology.
NP,
prevalent
presents
upper
back
due
thoracic
compression.
Anogenital
pruritus,
affecting
1-5%
adults,
linked
lumbosacral
issues
after
ruling
out
dermatologic
conditions
lichen
sclerosus
simplex
chronicus.
The
pathophysiology
involves
both
peripheral
central
mechanisms,
with
damage
being
key
factor.
Diagnosis
requires
thorough
history,
physical
examination,
potentially
imaging
studies.
Topical
agents
menthol,
capsaicin,
lidocaine
are
used
mild
while
systemic
medications
gabapentin,
pregabalin,
antidepressants
prescribed
moderate
cases;
however,
no
US
Food
Drug
Administration
(FDA)-approved
therapies
currently
exist
specifically
Understanding
underlying
appropriate
therapeutic
strategies
crucial
managing
effectively.
Язык: Английский
Practical guide for the diagnosis and treatment of localized and generalized cutaneous pruritus (chronic itch with no underlying pruritic dermatosis)
The Journal of Dermatology,
Год журнала:
2024,
Номер
52(2), С. 204 - 220
Опубликована: Дек. 12, 2024
Abstract
Itch,
also
known
as
pruritus,
is
one
of
the
most
prevalent
symptoms
observed
in
dermatological
practices.
Itch
frequently
arises
from
primary
pruritic
dermatoses,
although
it
may
manifest
absence
a
skin
rash.
The
latter
itchy
condition
referred
to
“cutaneous
pruritus”
Japanese
guidelines
published
2020.
Cutaneous
pruritus
can
be
classified
into
two
categories
based
on
its
distribution:
localized
cutaneous
and
generalized
pruritus.
Localized
indicative
neuropathic
cause,
whereas
suggests
underlying
systemic
disease(s),
drug‐induced
itch,
psychogenic
itch
(also
functional
disorder),
or
chronic
unknown
origin
(CPUO).
Systemic
diseases
associated
with
include
disorders
iron
metabolism,
kidney
disease,
liver
disease
(especially
cholestasis),
endocrine/metabolic
diseases,
hematological
disorders,
malignant
solid
tumors.
CPUO
term
used
describe
that
often
for
which
no
cause
identified
despite
comprehensive
careful
diagnostic
workup.
A
variety
treatment
approaches
are
available
including
device‐based
physical
therapies
(such
phototherapy)
medications
act
itch‐perception
processing
pathway
skin,
peripheral
sensory
nerves,
spinal
cord,
brain.
This
review
presents
an
overview
current
knowledge
regarding
pathophysiologic
mechanisms
procedures
currently
available.
Язык: Английский