Lipid nanoparticle (LNP) mediated mRNA delivery in neurodegenerative diseases
Journal of Controlled Release,
Год журнала:
2025,
Номер
unknown, С. 113641 - 113641
Опубликована: Март 1, 2025
Язык: Английский
Advances in clinical neurorestorative treatments of Parkinson’s disease
Yixuan Yin,
Dongning Su,
Joyce S. T. Lam
и другие.
Journal of Neurorestoratology,
Год журнала:
2025,
Номер
unknown, С. 100204 - 100204
Опубликована: Март 1, 2025
Язык: Английский
A Comprehensive Overview of the Current Status and Advancements in Various Treatment Strategies against Epilepsy
ACS Pharmacology & Translational Science,
Год журнала:
2024,
Номер
7(12), С. 3729 - 3757
Опубликована: Ноя. 1, 2024
Epilepsy
affects
more
than
70
million
individuals
of
all
ages
worldwide
and
remains
one
the
most
severe
chronic
noncommunicable
neurological
diseases
globally.
Several
neurotransmitters,
membrane
protein
channels,
receptors,
enzymes,
and,
recently
noted,
various
pathways,
such
as
inflammatory
mTORC
complexes,
play
significant
roles
in
initiation
propagation
seizures.
Over
past
two
decades,
developments
have
been
made
diagnosis
treatment
epilepsy.
Various
pharmacological
drugs
with
diverse
mechanisms
action
other
options
developed
to
control
seizures
treat
These
include
surgical
treatment,
nanomedicine,
gene
therapy,
natural
products,
nervous
stimulation,
a
ketogenic
diet,
gut
microbiota,
etc.,
which
are
developmental
stages.
Despite
plethora
options,
one-third
affected
resistant
current
medications,
while
majority
approved
side
effects,
changes
can
occur,
pharmacoresistance,
effects
on
cognition,
long-term
problems,
drug
interactions,
risks
poor
adherence,
specific
for
certain
psychological
complications.
Therefore,
development
new
that
no
or
minimal
adverse
is
needed
combat
this
deadly
disease.
In
Review,
we
comprehensively
summarize
explain
stages
epilepsy
well
their
status
clinical
trials
advancements.
Язык: Английский
Adeno-Associated Virus Therapies: Pioneering Solutions for Human Genetic Diseases
Cytokine & Growth Factor Reviews,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 1, 2024
Язык: Английский
Oligodendrocytes, the Forgotten Target of Gene Therapy
Cells,
Год журнала:
2024,
Номер
13(23), С. 1973 - 1973
Опубликована: Ноя. 28, 2024
If
the
billions
of
oligodendrocytes
(OLs)
populating
central
nervous
system
(CNS)
patients
could
express
their
feelings,
they
would
undoubtedly
tell
gene
therapists
about
frustration
with
other
neural
cell
populations,
neurons,
microglia,
or
astrocytes,
which
have
been
favorite
targets
transfer
experiments.
This
review
questions
why
OLs
left
out
most
therapy
attempts.
The
first
explanation
is
that
pathogenic
role
still
discussed
in
CNS
diseases.
Another
reason
so-called
ubiquitous
CAG,
CBA,
CBh,
CMV
promoters—widely
used
studies—are
unable
poorly
able
to
activate
transcription
episomal
transgene
copies
brought
by
adeno-associated
virus
(AAV)
vectors
OLs.
Accordingly,
expression
has
either
not
found
evaluated
studies
rodents
non-human
primates.
aims
current
are
give
rightful
place
among
cells
future
target
and
encourage
researchers
test
effect
OL
transduction
various
Язык: Английский