Economic burden of hospital admissions for adverse drug reactions in France: The IATROSTAT‐ECO study
British Journal of Clinical Pharmacology,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 3, 2024
Aims
Hospitalizations
for
adverse
drug
reactions
(ADR‐HA)
have
increased
over
the
last
decade,
but
impact
of
ADR‐HA
has
rarely
been
evaluated.
The
aim
this
study
was
to
estimate
economic
burden
in
France.
Methods
A
partial
evaluation
from
viewpoint
French
public
health
insurance
performed,
based
on
a
previous
pharmacovigilance
(IATROSTAT)
performed
2018
hospital
medical
units.
cost
included
direct
costs,
collected
retrospectively,
discharge
database.
estimated
by
calculating
total
per
patient
(cost
stays,
additional
daily
specific
such
as
resuscitation,
intensive
care
or
continuous
surveillance
unit,
products
and
devices
addition
Healthcare
Resource
Group‐based
tariffs,
outpatient
consultations
other
clinical
technical
procedures,
3
months
first
day
ADR‐HA).
robustness
results
assessed
using
one‐way
deterministic
sensitivity
analysis
factors
applying
tariffs
2023
instead
2018.
Results
According
(
vs
.
2023),
mean
with
at
€5208
±
€3719
€5974
€4232)
ranging
€514
€23
355
€618
€27
380).
196
patients
admitted
sample
hospitals
€1
020
549
170
960).
It
could
be
€1.3
billion
national
level.
Conclusions
In
increase
number
expensive
drugs,
ageing
population
polypharmacy,
serious
weighs
heavily
healthcare
spending.
Язык: Английский
Attitudes and beliefs of older adults and caregivers towards deprescribing in French-speaking countries: a multicenter cross-sectional study
European Journal of Clinical Pharmacology,
Год журнала:
2022,
Номер
78(10), С. 1633 - 1646
Опубликована: Июль 27, 2022
Язык: Английский
Potentially inappropriate medications and polypharmacy in the older population: A nationwide cross-sectional study in France in 2019
Therapies,
Год журнала:
2023,
Номер
78(5), С. 575 - 584
Опубликована: Фев. 9, 2023
To
assess
the
prevalence
of
potentially
inappropriate
medications
(PIMs)
and
polypharmacy
in
adults
aged
75
years
over
France
2019
based
on
data
from
French
health
insurance
claims
database,
at
national
level
by
region.
We
conducted
a
cross-sectional
study
or
2019.
assessed
seventeen
PIM
criteria
adapted
2015
Beers
STOPP
lists,
as
well
cumulative
polypharmacy.
Polypharmacy
(5
to
9
drugs)
hyper-polypharmacy
(≥10
were
defined
average
number
drugs
dispensed
per
quarter.
The
regional
analysis
used
age-
sex-standardized
prevalence.
Of
6,707,897
older
adults,
39.6%
exposed
least
one
2019,
46.7%
drugs),
25.2%
drugs).
Benzodiazepine
PIMs
most
frequent
(26.9%),
followed
atropinic
(8.3%),
non-steroidal
anti-inflammatory
(7.8%),
concomitant
use
three
more
central
nervous
system-active
(7.3%),
antihypertensive
(6.0%).
There
was
gradient
exposure
according
for
every
category.
observed
variations
prevalence,
36.5%
Pays-de-la-Loire
44.8%
Hauts-de-France
mainland
France.
These
results
show
that
concerned
than
after
age
support
need
secure
medication
this
population.
reasons
geographic
should
be
investigated
further
studies.
Язык: Английский
Cost outcomes of potentially inappropriate prescribing in middle‐aged adults: A Delphi consensus and cross‐sectional study
British Journal of Clinical Pharmacology,
Год журнала:
2022,
Номер
88(7), С. 3404 - 3420
Опубликована: Март 4, 2022
Potentially
inappropriate
prescribing
(PIP)
is
common
in
older
adults
and
associated
with
increased
medication
costs
of
adverse
drug
events.
PIP
also
affects
almost
1/5
middle-aged
(45-64
y),
as
defined
by
the
PRescribing
Optimally
Middle-aged
People's
Treatments
(PROMPT)
criteria.
However,
there
has
been
little
research
on
within
this
age
group.Calculate
for
according
to
22
PROMPT
criteria
compare
cost
consensus-validated,
evidence-based
(adequate)
alternative
scenarios.Adequate
alternatives
were
created
via
literature
review.
A
Delphi
consensus
panel
experts
was
recruited
(n
=
16),
supported
a
patient
public
involvement
group,
achieve
alternatives.
retrospective
repeated
cross-sectional
study
from
2014
2019
then
conducted
utilising
pseudonymised
primary
care
data
Lambeth
DataNet
South
London
(41
general
practices,
n
1
185
335,
using
May
2020
extract)
calculate
PIP.The
included
55
880
patients.
The
total
£2.79
million,
adequate
costing
£2.74
million
(cost
savings
£51
278).
Duplicate
classes
most
costly
criterion
both
prescribing.This
calculated
scenarios
There
no
substantial
difference
between
vs.
PIP.
Future
studies
should
investigate
wider
health
economic
prescribing,
such
reducing
hospital
admissions.
Язык: Английский
Variability in the prevalence of inappropriate medication use among older adults: A review highlighting the importance of screening methods and database types
British Journal of Clinical Pharmacology,
Год журнала:
2024,
Номер
90(7), С. 1559 - 1575
Опубликована: Май 16, 2024
Aims
The
global
older
population
is
growing
rapidly,
and
the
rise
in
polypharmacy
has
increased
potentially
inappropriate
medication
(PIM)
encounters.
PIMs
pose
health
risks,
but
detecting
them
automatically
large
medical
databases
complex.
This
review
aimed
to
uncover
PIM
prevalence
individuals
aged
65
years
or
using
emphasized
risk
of
underestimating
due
underutilization
detection
tools.
Methods
study
conducted
a
broad
search
on
Medline
database
identify
articles
about
adults
various
databases.
Articles
published
between
January
2010
June
2023
were
included,
specific
criteria
applied
for
selection.
Two
literature
reviews
before
our
period
integrated
obtain
perspective
from
1990s
present
day.
selected
papers
analysed
variables
including
type,
screening
method,
adaptations
prevalence.
categorized
original
tools
clarity,
examined
assessed
concordance
among
different
methods.
Results
encompassed
48
manuscripts,
covering
58
sample
evaluations.
mean
within
general
over
was
27.8%.
Relevant
heterogeneity
emerged
both
utilized
Adaptation
observed
86.2%
(50/58)
cases.
Half
used
assessing
belonged
simple
category.
About
third
studies
employed
less
than
half
after
adaptation.
Only
three
75%
more
50
criteria.
Conclusions
extensive
highlights
adults,
emphasizing
method
intricacies
potential
underestimation
data
limitations
algorithm
adjustments.
findings
call
enhanced
methodologies,
transparent
algorithms
deeper
understanding
intricate
rules'
impact
public
implications.
Язык: Английский
Drugs and the elderly: A complex interaction
Therapies,
Год журнала:
2023,
Номер
78(5), С. 559 - 563
Опубликована: Янв. 20, 2023
Язык: Английский
Attitudes and beliefs of older adults and caregivers towards deprescribing in French-speaking countries: a multicenter cross-sectional study
Research Square (Research Square),
Год журнала:
2022,
Номер
unknown
Опубликована: Май 11, 2022
Abstract
Purpose
Successful
deprescribing
requires
understanding
the
attitudes
of
older
adults
and
caregivers
towards
this
process.
This
study
aimed
to
capture
these
in
four
French-speaking
countries,
investigate
associated
factors.
Methods
A
multicenter
cross-sectional
was
conducted
by
administrating
French
version
revised
Patients’
Attitudes
Towards
Deprescribing
(rPATD)
questionnaire
Belgium,
Canada,
France
Switzerland.
Community-dwelling
or
nursing
home
≥
65
years
taking
1
prescribed
medications,
with
similar
characteristics
were
included.
Multivariate
logistic
regressions
carried
out
examine
factors
willingness
deprescribe.
Results
total
367
(79.3
±
8.7
years,
63%
community-dwelling,
54%
≥5
medications)
255
unrelated
(64.4
12.6
years)
care
recipients
(83.4
7.9
52%
69%
answered
questionnaire.
Among
them,
87.5%
75.6%
would
be
willing
stop
medications
if
physician
said
it
possible.
Reluctance
a
medication
taken
for
long
time
expressed
46%
both
caregivers.
low
score
factor
“concerns
about
stopping”
[older
adults:
aOR:
0.21;
95%CI:
0.07–0.59],
high
“involvement”
2.66;
1.01–7.07;
caregivers:
11.28;
1.48–85.91]
Conclusions
significant
proportion
speaking
countries
are
open
deprescribing.
Despite
apparent
willingness,
conversations
clinical
practice
remains
marginal,
emphasizing
importance
optimizing
integration
existing
tools
such
as
rPATD.
Язык: Английский