Country-specific psychopharmacological risk of reporting suicidality comparing 38 antidepressants and lithium comparing the FDA Adverse Event Reporting System, 2017–2023
Frontiers in Psychiatry,
Год журнала:
2024,
Номер
15
Опубликована: Ноя. 1, 2024
Background
The
United
States
Food
and
Drug
Administration
(FDA)
maintains
a
black-box
warning
for
antidepressants
of
an
increased
risk
suicidality
in
children
young
adults
that
is
based
on
proprietary
clinical
trial
data
from
study
sponsors
were
submitted
regulatory
approval.
This
article
aimed
to
assess
whether
the
still
valid
today
using
recent
drug
safety
data.
Methods
Post-marketing
adverse
event
obtained
US
FDA’s
Adverse
Event
Reporting
System
(FAERS)
years
2017
through
2023.
Logistic
regression
analysis
was
conducted
case
versus
non-case
methodology
adjusted
gender,
age
group,
role
(primary
drug,
secondary
interacting
concomitant
drug),
initial
FDA
reporting
year,
reporter
country,
drug*gene*age
group
interaction.
Results
In
multivariate
analysis,
compared
fluoxetine
patients
aged
25
64
years,
[adjusted
odds
ratio
(aROR)
=
7.38,
95%
CI,
6.02–9.05]
(aROR
3.49,
2.65–4.59)
associated
with
suicidality,
but
not
elderly
0.76,
0.53–1.09).
Relative
fluoxetine,
esketamine
highest
rate
3.20,
2.25–4.54);
however,
lower
0.59,
0.41–0.84),
significantly
0.77,
0.48–1.23).
For
country-specific
findings,
relative
USA,
Slovak
Republic,
India,
Canada
had
lowest
suicidality.
overall
population,
desvenlafaxine
0.61,
0.46–0.81)
vilazodone
0.56,
0.32–0.99)
only
two
reduced
Conclusion
shows
antidepressant
data,
prescribing
USA.
However,
15
countries
while
16
higher
38
lithium.
Язык: Английский
Renaissance of Ketamine
Prospects in Pharmaceutical Sciences,
Год журнала:
2024,
Номер
22(3), С. 156 - 163
Опубликована: Сен. 18, 2024
The
history
of
ketamine
began
in
the
1960s.
Ketamine
is
a
specific
anesthetic
drug
that
exhibits
analgesia,
has
stabilizing
impact
on
cardiovascular
system
and
does
not
significantly
depress
respiratory
system.
It
responsible
for
causing
so-called
dissociative
effect.
effects
depend
dose.
Its
mechanism
action
based
primarily
blockade
N-methyl
D-aspartic
acid
receptors
(NMDA)
central
nervous
Due
to
its
favorable
profile
small
number
contraindications,
becoming
an
increasingly
popular
drug.
In
medicine,
it
commonly
used
as
analgesic
anesthetic.
Studies
conducted
over
recent
years
have
noted
can
be
effective
conditions
such
as:
status
epilepticus,
asthmaticus,
agitation,
alcohol
dependence
withdrawal
syndrome,
depression,
suicidal
thoughts.
This
paper
reviews
current
reports
uses
ketamine,
beneficial
especially
physicians
with
Specialty
emergency
medicine.
Язык: Английский