Chemistry & Biodiversity,
Год журнала:
2024,
Номер
21(4)
Опубликована: Фев. 15, 2024
New
chalcones
were
synthesized
and
evaluated
to
serve
as
p38-α
type
of
mitogen-activated
protein
kinase
(MAPK)
inhibitors.
According
the
National
Cancer
Institute,
findings
indicated
that
at
a
10
μM
dosage,
compounds
3a
6
most
active
among
all
examined,
with
mean
growth
inhibition%
94.83
58.49,
respectively.
In
5-dose
testing,
they
showed
anticancer
activity
in
micro-molar
range
GI
Results in Chemistry,
Год журнала:
2024,
Номер
7, С. 101448 - 101448
Опубликована: Янв. 1, 2024
Present
work
elicits
synthesis
of
novel
azepane-acridines,
assisted
by
titania-encapsulated
γFe2O3
nanoparticles
supported
on
Vitamin
B1
(γFe2O3@TiO2-Vitamin
B1)
as
a
new
magnetically
recyclable
heterogeneous
nano-catalytic
system.
The
reaction
was
accomplished
using
biocompatible
PEG-200
(Polyethylene
glycol)
the
solvent
under
ultrasonic
irradiations.
structure
and
morphology
synthesized
magnetic
nano-catalyst
ascertained
based
data
obtained
from
powder
X-ray
diffraction
(PXRD),
field
emission
scanning
electron
microscopy
(FE-SEM),
energy-dispersive
spectroscopy
(EDAX),
Fourier
transform
infrared
(FT-IR),
VSM
(Vibrating-sample
magnetometer)
TGA,
DTA
DTG
techniques.
characteristic
size
prepared
heterogenous
is
34.62
nm.
Also,
structures
all
azepane-acridine
heterocyclic
scaffolds
were
corroborated
through
spectro-analytical
data.
These
compounds
found
to
have
remarkable
biological
activity
profile
against
bacterium
S.aureus
with
IC50
values
ranging
1.41
2.75
µg/mL.
Further,
these
in-vitro
studies
correlated
statistically
significant
2D/3D-
QSAR
models.
best
2D-QSAR
models
reveal
positive
influence
slogp
Vander
Waal
Surface
area
descriptors
while
negative
polar
surface
T_2_N_6
bioactivity
ideal
squared
correlation
coefficient
(r2),
cross-validated
(q2)
high
Fisher
ratio
(F-test)
indicating
model
be
relevant.
finest
3D-QSAR
MLR
(Multiple
Linear
Regression
method)
provide
practical
information
in
characterization
differentiation
compound
binding
sites.
Moreover,
molecular
docking
performed
evaluate
antifungal
black
fungi
crystal
protein,
bioassay
scores.
Atom
economy,
feasibility,
cost-effectiveness,
minimum
time,
High
yields,
an
additive-free
process
are
foremost
advantages
developed
methodology.
The Chemical Record,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 13, 2025
Abstract
Seven‐membered
nitrogen‐containing
heterocycles,
particularly
azepine‐based
compounds,
represent
an
intriguing
class
of
molecules
with
vast
arrays
applications.
These
compounds
have
garnered
considerable
attention
in
synthetic
and
medicinal
chemistry
due
to
their
non‐planar,
non‐aromatic
features,
which
offer
structural
flexibility
diversity
design
new
drugs
improved
pharmacological
properties.
This
review
summarizes
the
recent
advances
synthesis
azepine
derivatives,
including
eco‐friendly
methodologies
that
align
principles
green
chemistry,
emphasize
atom
economy,
sustainability,
waste
reduction.
Besides,
present
article
highlights
diverse
biological
activities,
viz.
anticancer,
antibacterial,
antifungal,
antiviral,
anti‐inflammatory,
neuroprotective
effects
derivatives.
Additionally,
discusses
key
aspects
such
as
molecular
docking
studies,
structure‐activity
relationships
(SAR),
mode
action
evident
through
preclinical
clinical
trials.
The
information
presented
current
would
assist
researchers
designing
developing
novel
leads
for
varied
therapeutic
ACS Omega,
Год журнала:
2023,
Номер
8(29), С. 26444 - 26457
Опубликована: Июль 17, 2023
Paracetamol
overdose
is
the
leading
cause
of
drug-induced
hepatotoxicity
worldwide.
Because
N-acetyl
cysteine's
limited
therapeutic
efficacy
and
safety,
searching
for
alternative
substitutes
necessary.
This
study
investigated
four
citrus
juices:
Citrus
sinensis
L.
Osbeck
var.
Pineapple
(pineapple
sweet
orange),
reticulata
Blanco
×
(Murcott
mandarin),
paradisi
Macfadyen
Ruby
Red
(red
grapefruit),
Fortunella
margarita
Swingle
(oval
kumquat)
to
improve
herbal
therapy
against
paracetamol-induced
liver
toxicity.
UHPLC-QTOF-MS/MS
profiling
samples
resulted
in
identification
about
40
metabolites
belonging
different
phytochemical
classes.
Phenolic
compounds
were
most
abundant,
with
total
content
ranked
from
609.18
1093.26
μg
gallic
acid
equivalent
(GAE)/mL
juice.
The
multivariate
data
analysis
revealed
that
phloretin
3',5'-di-C-glucoside,
narirutin,
naringin,
hesperidin,
2-O-rhamnosyl-swertisin,
fortunellin
(acacetin-7-O-neohesperidoside),
sinensetin,
nobiletin,
tangeretin
represented
crucial
discriminatory
segregated
analyzed
samples.
Nevertheless,
antioxidant
activity
was
1135.91-2913.92
μM
Trolox
eq/mL
juice,
718.95-3749.47
2304.74-4390.32
as
2,2'-azino-bis-3-ethylbenzthiazoline-6-sulfonic
acid,
ferric-reducing
power,
oxygen
radical
absorbance
capacity,
respectively.
vivo
model
rats
established
assessed
by
measuring
levels
hepatic
enzymes
biomarkers.
Interestingly,
concomitant
administration
juices
a
toxic
dose
paracetamol
effectively
recovered
injury,
confirmed
normal
sections
hepatocytes.
action
could
be
due
interactions
between
major
identified
(hesperidin,
hesperetin,
fortunellin,
poncirin,
apigenin-6,8-digalactoside,
6',7'-dihydroxybergamottin,
naringenin,
naringin)
cytochrome
P450
isoforms
(CYP3A4,
CYP2E1,
CYP1A2),
molecular
docking
study.
promising
three
processes
naringin.
Finally,
desirable
food-drug
interaction
achieved
our
research
overcome
overdose-induced
hepatotoxicity.
Future Medicinal Chemistry,
Год журнала:
2023,
Номер
15(19), С. 1773 - 1790
Опубликована: Окт. 1, 2023
Aim:
Our
objective
was
to
design
and
synthesize
a
new
range
of
pyrazolopyrimidines
while
maintaining
the
key
pharmacophoric
features
EGFR
tyrosine
kinase
inhibitors.
Materials
&
methods:
Percentage
inhibition
in
14
human
cancer
cell
lines
IC50
values
were
recorded.
Compounds
6c,
7e
7f
examined
against
both
wild
mutant
(T790M)
subtypes.
Apoptosis
markers,
cycle
arrest,
apoptosis
assay
molecular
docking
performed.
Results:
demonstrated
superior
inhibitory
potentials
A
study
showed
that
compounds
6c
had
best
fit.
Conclusion:
The
designed
candidates
potential
as
promising
EGFR-T790M
inhibitors
agrees
with
proposed
rationale.
