Autoimmune/inflammatory syndrome induced by adjuvants (ASIA): past, present, and future implications

Clinical & Experimental Immunology, Год журнала: 2023, Номер 213(1), С. 87 - 101

Опубликована: Март 7, 2023

Summary Adjuvants, as the name indicates, are adjoined material aimed to assist in functioning when added vaccines they meant boost effect and strongly stimulate immune system. The response of system can be unpredictable, autoimmune/inflammatory syndrome induced by adjuvants (ASIA) was developed address possible adverse reactions an autoimmune inflammatory type that may caused adjuvants. While ASIA, a syndrome, coined defined 2011; reports describing patients with vague nonspecific clinical symptoms following vaccinations appeared much earlier. In other words, ASIA came define, arrange, unite variety symptoms, related autoimmunity, not vaccine itself, rather adjuvant part such aluminum, among others. Accordingly, introduction enabled better understanding, proper diagnosis, early treatment disorder. Furthermore, shown associated almost all body systems various rheumatic diseases systemic lupus erythematosus, antiphospholipid sclerosis. addition, correlation between COVID-19 noticed during pandemic. this review, we summarized reported effects medical literature before after defined, several ways manifest impact different body, incidences It is important clarify, among, if the, most effective means fighting infectious however, believe manufacturing above criticism, particularly it comes substances possessing risk side effects.

Язык: Английский

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Effects of SARS-COV-2 infection during the frozen–thawed embryo transfer cycle on embryo implantation and pregnancy outcomes

Human Reproduction, Год журнала: 2024, Номер 39(6), С. 1239 - 1246

Опубликована: Апрель 11, 2024

Abstract STUDY QUESTION Does severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during the frozen–thawed embryo transfer (FET) cycle affect implantation and pregnancy rates? SUMMARY ANSWER There is no evidence that SARS-CoV-2 of women FET negatively affects rates. WHAT IS KNOWN ALREADY Coronavirus disease 2019 (COVID-19), as a multi-systemic disease, poses threat to reproductive health. However, effects on following fertility treatments, particularly FET, remain largely unknown. DESIGN, SIZE, DURATION This retrospective cohort study, included who underwent cycles between 1 November 2022 31 December at an academic centre. PARTICIPANTS/MATERIALS, SETTING, METHODS Women tested positive for their were in COVID-19 group, while those negative same study period non-COVID-19 group. The primary outcome was ongoing rate. Secondary outcomes rates implantation, biochemical pregnancy, clinical early loss, pregnancy. Multivariate logistic regression models applied adjust potential confounders including age, body mass index, gravidity, vaccination status, endometrial preparation regimen. Subgroup analyses conducted by time with respect (prior transfer, 1–7 days after or 8–14 transfer) level fever (no fever, <39°C, ≥39°C). MAIN RESULTS AND THE ROLE OF CHANCE A total 243 305 respectively. (58.8% vs 62.0%, P = 0.46), (53.1% 54.4%, 0.76), (46.4% 46.2%, 0.95), loss (24.5% 26.5%, 0.68), (44.4% 45.6%, 0.79) all comparable groups without infection. Results models, both before adjustment, revealed associations Moreover, neither nor ≥39°C) found be related LIMITATIONS, REASONS FOR CAUTION nature subject possible selection bias. Additionally, although sample size relatively large sizes certain subgroups small lacked adequate power, so these results should interpreted caution. WIDER IMPLICATIONS FINDINGS findings suggest females does not indicating cancellation due may necessary. Further studies are warranted verify findings. FUNDING/COMPETING INTEREST(S) supported National Key Research Development Program China (2023YFC2705500, 2019YFA0802604), Natural Science Foundation (82130046, 82101747), Shanghai leading talent program, Innovative research team high-level local universities (SHSMU-ZLCX20210201, SHSMU-ZLCX20210200, SSMU-ZLCX20180401), Jiao Tong University School Medicine Affiliated Renji Hospital Clinical Innovation Cultivation Fund (RJPY-DZX-003), Technology Commission Municipality (23Y11901400), Sailing (21YF1425000), Shanghai’s Top Priority Center Construction Project (2023ZZ02002), Three-Year Action Plan Strengthening Public Health System (GWVI-11.1-36), Municipal Education Commission-Gaofeng Grant Support (20161413). authors have conflicts interest declare. TRIAL REGISTRATION NUMBER N/A.

Язык: Английский

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SARS-CoV-2 evolution has increased resistance to monoclonal antibodies and first-generation COVID-19 vaccines: Is there a future therapeutic role for soluble ACE2 receptors for COVID-19?

Antiviral Research, Год журнала: 2024, Номер 227, С. 105894 - 105894

Опубликована: Апрель 25, 2024

Язык: Английский

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Selective IgA Deficiency May Be an Underrecognized Risk Factor for Severe COVID-19

The Journal of Allergy and Clinical Immunology In Practice, Год журнала: 2022, Номер 11(1), С. 181 - 186

Опубликована: Окт. 12, 2022

Язык: Английский

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Soluble wild-type ACE2 molecules inhibit newer SARS-CoV-2 variants and are a potential antiviral strategy to mitigate disease severity in COVID-19

Clinical & Experimental Immunology, Год журнала: 2023, Номер 214(3), С. 289 - 295

Опубликована: Авг. 11, 2023

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for disease of 2019 (COVID-19), has caused havoc around world. While several COVID-19 vaccines and drugs have been authorized use, these antiviral remain beyond reach most low- middle-income countries. Rapid viral evolution is reducing efficacy monoclonal antibodies contributing to deaths some fully vaccinated persons. Others with normal immunity may chosen not be at risk if they contract infection. Vaccines protect immunodeficient patients from SARS-CoV-2, who are also increased chronic infection, a dangerous stalemate between suboptimal immune response. Intra-host could rapidly lead selection dominance vaccine antibody-resistant clades SARS-CoV-2. There thus an urgent need develop new treatments COVID-19. The NZACE2-Pātari project, comprising modified soluble angiotensin-converting enzyme (ACE2) molecules, seeks intercept block SARS-CoV-2 infection mucosa. In vitro data presented here show that wild-type ACE2 molecules retain ability effectively Spike (S) glycoprotein variants including ancestral Wuhan, delta (B.1.617.2) omicron (B.1.1.529) strains. This therapeutic strategy prove effective implemented early during nasal phase act synergistically other such as Paxlovid further mitigate severity.

Язык: Английский

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The autoimmune rheumatological presentation of Common Variable Immunodeficiency Disorders with an overview of genetic testing

Seminars in Arthritis and Rheumatism, Год журнала: 2024, Номер 65, С. 152387 - 152387

Опубликована: Янв. 21, 2024

Язык: Английский

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Barriers to COVID-19 vaccine surveillance: the issue of under-reporting adverse events

Epidemiology and Health, Год журнала: 2023, Номер 45, С. e2023054 - e2023054

Опубликована: Июнь 7, 2023

This study investigated the reporting rates of adverse events following immunization (AEFIs) to spontaneous system (SRS) and its predictors among individuals with AEFIs after coronavirus disease 2019 (COVID-19) vaccination.A cross-sectional, web-based survey was conducted from December 2, 2021 20, 2021, recruiting participants >14 days completion a primary COVID-19 vaccination series. Reporting were calculated by dividing number who reported SRS total experienced AEFIs. We estimated adjusted odds ratios (aORs) using multivariate logistic regression determine factors associated reporting.Among 2,993 participants, 90.9% 88.7% first second vaccine doses, respectively (reporting rates, 11.6 12.7%). Furthermore, 3.3% 4.2% suffered moderate severe AEFIs, 50.5 50.0%). Spontaneous more prevalent in female (aOR, 1.54; 95% confidence interval [CI], 1.31 1.81); those 5.47; CI, 4.45 6.73), comorbidities 1.31; 1.09 1.57), history allergic reactions 2.02; 1.47 2.77); had received mRNA-1273 1.25; 1.05 1.49) or ChAdOx1 1.62; 1.15 2.30) vaccines versus BNT162b2. less likely older 0.98; 0.98 0.99 per 1-year age increment).Spontaneous younger age, sex, comorbidities, reactions, type. under-reporting should be considered when delivering information community public health decision-making.

Язык: Английский

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Critical role of diagnostic SARS-CoV-2 T cell assays for immunodeficient patients

Journal of Clinical Pathology, Год журнала: 2022, Номер 75(12), С. 793 - 797

Опубликована: Окт. 10, 2022

After almost 3 years of intense study, the immunological basis COVID-19 is better understood. Patients who suffer severe disease have a chaotic, destructive immune response. Many patients with produce high titres non-neutralising antibodies, which are unable to sterilise infection. In contrast, there increasing evidence that rapid, balanced cellular response required eliminate virus and mitigate severity. longer term, memory T cell responses, following infection or vaccination, play critical role in protection against SARS-CoV-2.Given pivotal immunity COVID-19, diagnostic assays for SARS-CoV-2 may be particular value immunodeficient patients. A assay would utility immunocompromised antibodies passively acquired from subcutaneous intravenous immunoglobulin (SCIG/IVIG) replacement. many antibody-deficient patients, responses preserved. identify breakthrough infections if reverse transcriptase quantitative PCR (RT-qPCR) rapid antigen tests (RATs) not undertaken during window viral shedding. addition immunodeficiency, could also chronically symptomatic long were infected early pandemic. These individuals been before availability reliable RT-qPCR RAT their waned. greater durability than can distinguish vaccinated individuals.

Язык: Английский

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Association between COVID-19 vaccines and development of chronic morbidities: a cross-sectional study in the Jordanian population

Current Medical Research and Opinion, Год журнала: 2024, Номер 40(3), С. 537 - 543

Опубликована: Янв. 9, 2024

Background In Jordan, individuals recently diagnosed with chronic illnesses have expressed concerns regard to COVID-19 vaccines. This study aims investigate potential associations between vaccination and the likelihood of recipients developing conditions such as autoimmune diseases, rheumatoid arthritis, diabetes, asthma, hypertension.

Язык: Английский

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Vaccine hesitancy is not increased in patients with ASIA (autoimmune/inflammatory syndrome induced by adjuvants) when compared to patients with vasculitis

Clinical Rheumatology, Год журнала: 2023, Номер 42(6), С. 1727 - 1728

Опубликована: Апрель 1, 2023

Язык: Английский

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