Irritability in Children with Rasopathies, Insights into Emotional Dysregulation and Social Skills Impairments DOI Creative Commons
Yaffa Serur,

Naomi Fuhrman,

Odeya Russo

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Дек. 19, 2024

Abstract Rasopathies, including Noonan Syndrome (NS) and Neurofibromatosis type 1 (NF1), are developmental disorders caused by germline mutations in genes of the RAS/mitogen-activated protein kinase pathway (RAS-MAPK). This study investigates irritability, a highly prevalent transdiagnostic construct, children with Rasopathies impact Rasopathy status on associations between emotional dysregulation-related disorders, social skills impairments. The sample comprise 174 aged 4–17 (age mean = 9.49; 98 females), 113 (NS n 85, NF1 28) 61 age-sex-matched typically developed (TD) children. We used parent questionnaires (CBCL, SRS) to assess symptoms ADHD, defiance, anxiety/depression, impairments while controlling for cognitive measures (IQ). Children exhibited higher irritability than TD (mean difference 1.09; p < 0.001). NS showed weaker association ADHD compared (p .032, ηp2 .03) stronger both .033, .03), groups .009, .06). present novel clinically significant findings showing high Rasopathies. Our provides syndrome-specific results, suggesting differences mechanisms involved processes NF1. In essence, irritable profile associated impairments, significantly NS. results suggest that developing prevention treatments targeting can distinctly affect trajectories neurodevelopmental

Язык: Английский

Assessing Dimensions of Aggressive Behavior in Diverse Youth: The Peer Conflict Scale in English and Spanish DOI Creative Commons
Denise López Sosa, Kate Simmons, Ashley R. Karlovich

и другие.

JAACAP Open, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Treating pediatric aggressive behaviors and comorbid conditions DOI
E. N. Stepanova, Joshua A. Langfus, James Blair

и другие.

Expert Opinion on Pharmacotherapy, Год журнала: 2025, Номер unknown

Опубликована: Март 30, 2025

Introduction Aggressive behaviors in children and adolescents can significantly impair quality of life, leading to disruptions both academic social functioning. Despite decades research, a standardized nosology for aggressive remains lacking, resulting considerable variability the design treatment trials aggression.

Язык: Английский

Процитировано

0
Development and Validation of a Multi-Informant Scale for Assessing Youth Tonic and Phasic Irritability DOI
Jamilah Silver, Gabrielle A. Carlson, Wilfred Farquharson

и другие.

Research on Child and Adolescent Psychopathology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 15, 2025

Язык: Английский

Процитировано

0
The Affective Side of Disruptive Behavior: Toward Better Understanding, Assessment, and Treatment DOI Creative Commons
Spencer C. Evans, Jeffrey D. Burke

Journal of Clinical Child & Adolescent Psychology, Год журнала: 2024, Номер 53(2), С. 141 - 155

Опубликована: Март 3, 2024

Historically, much of the progress made in youth mental health research can be classified as focusing on

Язык: Английский

Процитировано

2
Irritability in children: Promising advances in measurement and treatment DOI Open Access

Anne S. Walters

The Brown University Child and Adolescent Behavior Letter, Год журнала: 2024, Номер 40(9), С. 8 - 8

Опубликована: Авг. 7, 2024

Extreme irritability is a challenging quality for children and adolescents those that live with them; one often brings them into treatment due to the impact on others. Further, it also leads cycle of interpersonal rejection from others based unpleasantness interaction such an individual. For these reasons, both anger have received increasing attention researchers clinicians in recent years, yet conceptualization still murky, as measurement. Is temperament? sign pathology? Specific mood disorders or cross‐sectional symptom? Stable enduring, not?

Язык: Английский

Процитировано

0
Understanding irritability through the lens of self-regulatory control processes in children and adolescents: a systematic review DOI Creative Commons
Sébastien Urben,

Ana Ochoa Williams,

Cécile Ben Jemia

и другие.

European Child & Adolescent Psychiatry, Год журнала: 2024, Номер unknown

Опубликована: Окт. 8, 2024

Abstract Among youths, pathological irritability is highly prevalent and severely disabling. As a frequent symptom, it often leads to referrals child adolescent mental health services. Self-regulatory control (SRC) processes are set of socio-psycho-physiological that allow individuals adapt their ever-changing environments. This conceptual framework may enhance the current understanding cognitive, emotional, behavioural social dysregulations underlying irritability. The present systematic review (PROSPERO registration: #CRD42022370390) aims synthesize existing studies examine through lens SRC among youths (< 18 years age). We conducted comprehensive literature search six bibliographic databases: Embase.com, Medline ALL Ovid, APA PsycInfo Web Science Core Collection, Cochrane Database Systematic Reviews Wiley ProQuest Dissertations & Theses A&I. Additional searches were performed using citation tracing strategies. retrieved reports totalled 2612, which we included 82 (i.e., articles) from 74 studies. More than 85% published during last 6 years, highlighting topicality this work. sampled n = 26,764 participants (n 12,384 girls 12,905 boys, 1475 no information) with an average age 8.08 (SD 5.26). suggest has association lower effortful control, cognitive delay intolerance. Further, evidence indicates both cross-sectional longitudinal associations between lack regulation skills for positive negative emotions, particularly anger. Physiological seems moderate psychopathology. Finally, mutual influence child’s parenting practice been established in several uses illustrate psychopathology, discusses important gaps literature, highlights new avenues further research.

Язык: Английский

Процитировано

0
Peer socialization processes in the development of callous-unemotional traits DOI Creative Commons
Gretchen R. Perhamus, Jamie M. Ostrov

Development and Psychopathology, Год журнала: 2024, Номер unknown, С. 1 - 18

Опубликована: Дек. 10, 2024

Abstract Callous-unemotional (CU) traits represent a risk factor for persistent, severe levels of externalizing problems. Irritability may predict the development CU some individuals, who are thought to acquire them in reaction negative environmental experiences. Models on have emphasized socializing role harsh parenting neglect peer The present study 1) tested primary and alternative models physical relational victimization as socialization agents relations between irritability traits; 2) considered hypothalamic-pituitary-adrenal-axis functioning moderator these associations. Gender moderation was also considered. Aims were from middle childhood adolescence using data NICHD Study Early Child Care Youth Development, which includes large national sample ( N = 1,077) multiple methods informants constructs interest. Positive associations irritability, victimization, supported, with indirect effects supported specifically through increases irritability. Associations be particularly salient females, whose experiences been neglected date. However, small, replication efforts needed.

Язык: Английский

Процитировано

0
Irritability in Children with Rasopathies, Insights into Emotional Dysregulation and Social Skills Impairments DOI Creative Commons
Yaffa Serur,

Naomi Fuhrman,

Odeya Russo

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Дек. 19, 2024

Abstract Rasopathies, including Noonan Syndrome (NS) and Neurofibromatosis type 1 (NF1), are developmental disorders caused by germline mutations in genes of the RAS/mitogen-activated protein kinase pathway (RAS-MAPK). This study investigates irritability, a highly prevalent transdiagnostic construct, children with Rasopathies impact Rasopathy status on associations between emotional dysregulation-related disorders, social skills impairments. The sample comprise 174 aged 4–17 (age mean = 9.49; 98 females), 113 (NS n 85, NF1 28) 61 age-sex-matched typically developed (TD) children. We used parent questionnaires (CBCL, SRS) to assess symptoms ADHD, defiance, anxiety/depression, impairments while controlling for cognitive measures (IQ). Children exhibited higher irritability than TD (mean difference 1.09; p < 0.001). NS showed weaker association ADHD compared (p .032, ηp2 .03) stronger both .033, .03), groups .009, .06). present novel clinically significant findings showing high Rasopathies. Our provides syndrome-specific results, suggesting differences mechanisms involved processes NF1. In essence, irritable profile associated impairments, significantly NS. results suggest that developing prevention treatments targeting can distinctly affect trajectories neurodevelopmental

Язык: Английский

Процитировано

0