Molecular Mechanism of Action of Abamectin on Human Microglia Clone 3 Cell Line

Applied In Vitro Toxicology, Год журнала: 2025, Номер 11(1), С. 16 - 20

Опубликована: Фев. 20, 2025

Introduction: Abamectin (ABA) is an insecticide that commonly used in agricultural spraying. Although it known to have neurotoxic effects on living organisms the ecosystem and humans, details of these effects, including duration amount exposure, are not fully understood. The aim this study evaluate effect ABA exposure human microglia clone 3 (HMC3) cells. These cells were chosen because they suitable for modeling immunological functions such as cytokine production, cell migration, inflammation response.

Язык: Английский

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The Dual Roles of STAT3 in Ferroptosis: Mechanism, Regulation and Therapeutic Potential

Journal of Inflammation Research, Год журнала: 2025, Номер Volume 18, С. 4251 - 4266

Опубликована: Март 1, 2025

Ferroptosis, an iron-dependent programmed mechanism of cell death that is driven by lipid peroxidation, important pathogenic factor in oncological and non-oncological disorders. Dysregulation iron metabolism profoundly influences disease progression through ferroptosis modulation. Signal transducer activator transcription 3 (STAT3), a transcriptional regulator, regulates binding to promoters key molecules such as solute carrier family 7 member 11 (SLC7A11), glutathione peroxidase 4 (GPX4), ferritin heavy chain 1 (FTH1). In this review, we described the role STAT3 supporting tumors survival suppressing malignancies, bidirectionally regulating non-tumors regulate development disease. We also reported emerging therapeutic strategies target STAT3-mediated ferroptosis, including natural phytochemicals, inhibitors, nanotechnology-enabled drug delivery systems. These advancements deepen mechanistic understanding regulation, provide new theoretical bases treat ferroptosis-related diseases.

Язык: Английский

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Lipid metabolism in ferroptosis: Unraveling key mechanisms and therapeutic potential in cancer

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2024, Номер 1880(1), С. 189258 - 189258

Опубликована: Дек. 31, 2024

Язык: Английский

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Inhibition of CDGSH iron‑sulfur domain 2 exhibits tumor-suppressing effects on diffuse large B-cell lymphoma (DLBCL) by inducing ferroptosis through the regulation of the NRF2/SLC7A11/GPX4 pathway

Toxicology and Applied Pharmacology, Год журнала: 2024, Номер 493, С. 117148 - 117148

Опубликована: Ноя. 8, 2024

Язык: Английский

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Synergistic effects of dihydroartemisinin and cisplatin on inducing ferroptosis in gastric cancer through GPX4 inhibition

Gastric Cancer, Год журнала: 2024, Номер unknown

Опубликована: Дек. 29, 2024

Язык: Английский

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