Advancements in Microextraction by Packed Sorbent: Insights into Sorbent Phases and Automation Strategies
Separations,
Год журнала:
2025,
Номер
12(1), С. 11 - 11
Опубликована: Янв. 8, 2025
Miniaturized
solid-based
approaches
have
added
an
eco-friendly
dimension
to
analytical
procedures,
establishing
themselves
as
promising
strategies
for
a
wide
range
of
applications.
Among
these,
microextraction
by
packed
sorbent
(MEPS)
stands
out
due
its
ability
facilitate
efficient
sample
interaction
with
densely
sorb
ent
phase
within
the
system.
MEPS
offers
several
advantages,
including
preconcentration
capabilities
and
use
minimal
solvent
volumes,
making
it
appealing
choice
modern
workflows.
Since
extraction
efficiency
is
largely
dictated
phase,
recent
advancements
in
design
garnered
considerable
attention
field
preparation.
Innovations
phases
not
only
enhanced
but
also
enabled
development
semi-
fully
automated
systems,
paving
way
high-throughput
methodologies.
These
elevated
beyond
traditional
offline
miniaturized
preparation
methods,
offering
new
opportunities
streamlined
scalable
analyses.
Therefore,
this
study
provides
comprehensive
overview
novel
used
MEPS,
particular
focus
on
both
bio-based
synthetic
materials.
Furthermore,
explores
aspects
highlighting
current
trends,
technological
advancements,
future
directions
rapidly
evolving
field.
Язык: Английский
Optimization of Capillary Electrophoresis by Central Composite Design for Separation of Pharmaceutical Contaminants in Water Quality Testing
Environments,
Год журнала:
2025,
Номер
12(1), С. 22 - 22
Опубликована: Янв. 12, 2025
Many
pharmaceutical
active
compounds
are
prepared
as
hydrochlorides
for
quick
release
in
the
gastrointestinal
tract
upon
oral
administration.
Their
inadvertent
escape
into
water
environment
requires
efficient
analytical
separation
accurate
quantitation
to
monitor
their
environmental
fate.
The
purpose
of
this
study
is
demonstrate
how
best
optimize
a
capillary
electrophoresis
method
four
model
hydrochlorides.
Concentration
sodium
dibasic
phosphate
background
electrolyte
solution,
pH
adjustment
with
HCl
or
NaOH,
and
applied
voltage
across
were
three
key
factors
chosen
optimization.
peak
resolutions
total
migration
time
examined
response
indicators
complete
central
composite
design
surface
methodology.
examination
revealed
that
CE
was
driven
significantly
by
linear
regression
minimally
quadratic
model,
based
on
coefficient
determination,
lack
fit,
sum
squares,
p
values.
Under
optimal
conditions
concentration
75
mM,
9,
10
kV,
separated
within
five
minutes
order
metformin
(first)
>
phenformin
mexiletine
ranitidine
(last).
limits
UV
detection/quantification
attained
under
0.015/0.045,
0.020/0.060,
0.142/0.426,
0.017/0.051,
respectively.
Язык: Английский
Isolation of Biomolecules Using MXenes
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 11, 2024
Biomolecule
isolation
is
a
crucial
process
in
diverse
biomedical
and
biochemical
applications,
including
diagnostics,
therapeutics,
research,
manufacturing.
Recently,
MXenes,
novel
class
of
two-dimensional
nanomaterials,
have
emerged
as
promising
adsorbents
for
this
purpose
due
to
their
unique
physicochemical
properties.
These
biocompatible
antibacterial
nanomaterials
feature
high
aspect
ratio,
excellent
conductivity,
versatile
surface
chemistry.
This
timely
review
explores
the
potential
MXenes
isolating
wide
range
biomolecules,
such
proteins,
nucleic
acids,
small
molecules,
while
highlighting
key
future
research
trends
innovative
applications
poised
transform
field.
provides
an
in-depth
discussion
various
synthesis
methods
functionalization
techniques
that
enhance
specificity
efficiency
biomolecule
isolation.
In
addition,
mechanisms
by
which
interact
with
biomolecules
are
elucidated,
offering
insights
into
selective
adsorption
customized
separation
capabilities.
also
addresses
recent
advancements,
identifies
existing
challenges,
examines
emerging
may
drive
next
wave
innovation
rapidly
evolving
area.
Язык: Английский