Sugar‐sensing swodkoreceptors and swodkocrine signaling
Animal Models and Experimental Medicine,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 20, 2025
Abstract
Sugars
are
one
of
the
major
metabolites
and
essential
for
nucleic
acid
synthesis
energy
production.
In
addition,
sugars
can
act
as
signaling
molecules.
To
study
sugar
at
systemic
level,
there
is
an
urgent
need
to
systematically
identify
sugar‐sensing
proteins
acids.
I
propose
terms
“swodkoreceptor”
“swodkocrine
signaling,”
derived
from
Polish
word
“słodki”
meaning
“sweet,”
comprise
all
events,
respectively,
regardless
their
cellular
location
domains.
This
proposal
intended
facilitate
inclusion
such
Escherichia
coli
LacI
repressor
allolactose
receptor,
human
glucokinase
regulatory
protein
(GCKR)
a
fructose
other
sugar‐binding
based
allosterically
regulated
enzymes
transcription
factors
receptors.
enzyme‐interacting
whose
interaction
state
by
binding
have
also
been
proposed
The
protein‐
nucleic‐acid‐based
swodkoreceptors
may
help
organelle‐specific
address
receptor
duality.
intra‐
inter‐organism
swodkocrine
its
crosstalk
with
gasocrine
understand
etiology
diseases
due
dysregulation
in
homeostasis
signaling.
Язык: Английский
Gas-sensing riboceptors
RNA Biology,
Год журнала:
2024,
Номер
21(1), С. 1 - 6
Опубликована: Июль 17, 2024
Understanding
how
cells
sense
gases
or
gaseous
solutes
is
a
fundamental
question
in
biology
and
pivotal
for
the
evolution
of
molecular
organismal
life.
In
numerous
organisms,
can
diffuse
into
cells,
be
transported,
generated,
sensed.
Controlling
cellular
environment
essential
to
prevent
damage
due
interactions
with
gas-dependent
free
radicals.
Consequently,
mechanisms
governing
acute
gas
sensing
are
evolutionarily
conserved
have
been
experimentally
elucidated
various
organisms.
However,
scientific
literature
on
direct
largely
based
hemoprotein-based
gasoreceptors
(or
sensors).
As
RNA-based
G-quadruplex
(G4)
structures
also
bind
heme,
I
propose
that
some
ribozymes
contain
associated
heme-binding
G4
act
as
gas-sensing
riboceptors
(ribonucleic
acid
receptors).
Additionally,
present
few
other
ideas
non-heme
metal
ion-
cluster-based
riboceptors.
Studying
help
understand
evolutionary
origins
environmental
sensing,
gasocrine
signaling,
interspecies
communication.
Язык: Английский