Kynurenine amplifies tetrahydrocannabinol-induced sensorimotor impairment and classic “tetrad” effects in mice
Progress in Neuro-Psychopharmacology and Biological Psychiatry,
Год журнала:
2025,
Номер
unknown, С. 111342 - 111342
Опубликована: Март 1, 2025
Язык: Английский
Altered local intrinsic neural activity and molecular architecture in internet use disorders
Brain Research Bulletin,
Год журнала:
2024,
Номер
216, С. 111052 - 111052
Опубликована: Авг. 20, 2024
Internet
gaming
disorder
(IGD)
is
mainly
characterized
by
its
core
dysfunction
in
higher-order
brain
cortices
involved
inhibitory
control,
whose
neurobiological
basis
remains
unclear.
Then,
we
will
investigate
local
intrinsic
neural
activity
(INA)
alterations
IGD,
ascertain
whether
these
potential
are
related
to
clinical
characteristics,
and
further
explore
the
underlying
molecular
architecture.
Язык: Английский
Loop diuretics inhibit kynurenic acid production and kynurenine aminotransferases activity in rat kidneys
Pharmacological Reports,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 11, 2024
Язык: Английский
Effect of Tryptophan Restriction in the Therapy of Irritable Bowel Syndrome: a Systematic Review
Ben Wang,
Peilin Cheng,
Bingjie Jin
и другие.
International Journal of General Medicine,
Год журнала:
2024,
Номер
Volume 17, С. 4141 - 4151
Опубликована: Сен. 1, 2024
The
metabolic
pathways
of
tryptophan
(TRP)
have
been
implicated
in
the
pathophysiology
irritable
bowel
syndrome
(IBS),
positing
that
strategic
modulation
TRP
consumption
may
exert
regulatory
effects
on
serotonin
levels,
consequently
altering
clinical
manifestation
IBS.
This
systematic
review
was
meticulously
orchestrated
to
evaluate
effect
restriction
Язык: Английский
Gene Variant Frequencies of IDO1, IDO2, TDO, and KMO in Substance Use Disorder Cohorts
Genes,
Год журнала:
2024,
Номер
15(11), С. 1388 - 1388
Опубликована: Окт. 29, 2024
Substance
use
disorder
in
the
United
States
represents
a
complex
and
growing
public
health
crisis,
marked
by
increasing
rates
of
overdose
deaths
misuse
prescription
medications.
There
is
critical
need
for
furthering
understanding
molecular
genetic
mechanisms
that
can
lead
to
substance
disorder.
Identifying
significant
variants
kynurenine
pathway
could
help
identify
therapeutic
targets
intervention.
Язык: Английский
Impact of Substance Use Disorder on Tryptophan Metabolism Through the Kynurenine Pathway: A Narrative Review
Metabolites,
Год журнала:
2024,
Номер
14(11), С. 611 - 611
Опубликована: Ноя. 10, 2024
:
Substance
use
disorder
is
a
crisis
impacting
many
people
in
the
United
States.
This
review
aimed
to
identify
effect
addictive
substances
have
on
kynurenine
pathway.
Tryptophan
an
essential
amino
acid
metabolized
by
serotonin
and
pathways.
The
metabolites
of
these
pathways
play
role
biological
reward
system.
Addictive
been
shown
cause
imbalances
ratios
metabolites.
With
current
treatment
therapeutic
options
being
suboptimal,
identifying
biochemical
mechanisms
that
are
impacted
during
can
provide
alternative
for
or
drug
discovery.
Язык: Английский