Brain Behavior and Immunity,
Год журнала:
2024,
Номер
119, С. 211 - 219
Опубликована: Март 27, 2024
Sexual
minority
individuals
have
a
markedly
elevated
risk
of
depression
compared
to
heterosexuals.
We
examined
early
threats
social
safety
and
chronically
inflammation
as
mechanisms
contributing
this
disparity
in
symptoms,
the
relative
strength
co-occurrence
between
chronic
symptoms
for
sexual
minorities
versus
To
do
so,
we
analyzed
data
from
prospective
cohort
heterosexual
young
adults
(n
=
595),
recruited
nationally
representative
sample,
that
included
assessments
form
adverse
childhood
interpersonal
events,
three
biomarkers
(i.e.,
CRP,
IL-6,
TNF-α)
measured
at
two
time
points,
over
four
years.
In
pre-registered
analyses,
found
experienced
more
were
likely
display
inflammation,
reported
severe
than
Adverse
events
explained
approximately
23
%
total
effect
association
orientation
symptom
severity.
Further,
there
was
an
increased
coupling
among
These
results
provide
novel
longitudinal,
population-based
evidence
role
linking
during
with
severity
adulthood,
consistent
primary
tenets
signal
transduction
theory
depression.
Our
study
extends
population
level
by
finding
members
stigmatized
minorities)
experience
greater
because
their
exposure
subsequent
link
highlighting
potential
biopsychosocial
intervention
targets.
Brain Behavior & Immunity - Health,
Год журнала:
2024,
Номер
38, С. 100793 - 100793
Опубликована: Май 8, 2024
Although
seasonal
changes
in
physiology
are
well
documented,
little
is
known
about
how
human
immune
and
metabolic
markers
vary
across
seasons,
no
studies
have
examined
stress
→
health
biomarker
associations
differ
the
year.
To
investigate
these
issues,
we
analyzed
data
from
2118
participants
of
Midlife
United
States
(MIDUS)
study
to
determine
whether
there
were
differences
(a)
levels
19
markers,
(b)
association
between
perceived
each
Results
component-wide
boosted
generalized
additive
models
revealed
patterning
for
most
biomarkers,
with
proteins
generally
peaking
when
days
shorter.
Moreover,
whereas
hemoglobin
A1C
rose
late
fall
spring,
triglycerides
elevated
summer
fall,
high-density
lipoprotein
decreased
steadily
January
December.
Urinary
cortisol
cortisone
exhibited
opposite
patterns,
at
beginning
end
year,
respectively.
Most
critically,
found
that
effects
on
18
biomarkers
assessed
varied
by
month
measurement.
In
some
cases,
involved
magnitude
but,
other
it
was
direction
effect
changed.
Studies
do
not
account
assessment
may
thus
yield
misleading
or
unreproducible
results.
Brain Behavior and Immunity,
Год журнала:
2023,
Номер
115, С. 747 - 757
Опубликована: Окт. 31, 2023
Women
using
hormonal
contraceptives
(HCs)
exhibit
numerous
signs
of
chronic
inflammation,
including
elevated
C-reactive
protein
levels
and
greater
risk
developing
mood
autoimmune
disorders.
However,
users
non-users
HCs
often
have
similar
circulating
proinflammatory
cytokine
levels,
making
the
mechanism
association
unclear.
One
possible
explanation
for
this
paradox
is
that
HC
differences
in
their
inflammatory
responses
to
psychosocial
stress
that,
over
time,
could
contribute
inflammation
its
pathologies.
Here,
we
tested
possibility
by
examining
women's
glucocorticoid,
inflammatory,
psychological
Trier
Social
Stress
Test
(TSST)
67
naturally
cycling
(NC)
60
oral
HC-using
women
(M
Journal of Clinical Medicine,
Год журнала:
2023,
Номер
13(1), С. 24 - 24
Опубликована: Дек. 19, 2023
Despite
great
interest
in
how
dynamic
fluctuations
psychological
states
such
as
mood,
social
safety,
energy,
present-focused
attention,
and
burnout
impact
stress,
well-being,
health,
most
studies
examining
these
constructs
use
retrospective
assessments
with
relatively
long
time-lags.
Here,
we
discuss
ecological
momentary
(EMAs)
address
methodological
issues
associated
reports
to
help
reveal
associations
between
at
small
timescales
that
are
often
missed
stress
health
research.
In
addition
helping
researchers
characterize
daily
within-day
temporal
dynamics
different
health-relevant
processes,
EMAs
can
elucidate
mechanisms
through
which
interventions
reduce
enhance
well-being.
also
be
used
identify
changes
precede
critical
events,
turn
deliver
interventions,
or
just-in-time
prevent
events
from
occurring.
To
enable
this
work,
provide
examples
of
scales
single-item
questions
EMA
studies,
recommend
study
designs
statistical
approaches
capitalize
on
data,
limitations
methods.
doing
so,
aim
demonstrate
how,
when
carefully,
methods
well
poised
greatly
advance
our
understanding
intrapersonal
affect
levels,
human
health.
Brain Behavior and Immunity,
Год журнала:
2024,
Номер
119, С. 211 - 219
Опубликована: Март 27, 2024
Sexual
minority
individuals
have
a
markedly
elevated
risk
of
depression
compared
to
heterosexuals.
We
examined
early
threats
social
safety
and
chronically
inflammation
as
mechanisms
contributing
this
disparity
in
symptoms,
the
relative
strength
co-occurrence
between
chronic
symptoms
for
sexual
minorities
versus
To
do
so,
we
analyzed
data
from
prospective
cohort
heterosexual
young
adults
(n
=
595),
recruited
nationally
representative
sample,
that
included
assessments
form
adverse
childhood
interpersonal
events,
three
biomarkers
(i.e.,
CRP,
IL-6,
TNF-α)
measured
at
two
time
points,
over
four
years.
In
pre-registered
analyses,
found
experienced
more
were
likely
display
inflammation,
reported
severe
than
Adverse
events
explained
approximately
23
%
total
effect
association
orientation
symptom
severity.
Further,
there
was
an
increased
coupling
among
These
results
provide
novel
longitudinal,
population-based
evidence
role
linking
during
with
severity
adulthood,
consistent
primary
tenets
signal
transduction
theory
depression.
Our
study
extends
population
level
by
finding
members
stigmatized
minorities)
experience
greater
because
their
exposure
subsequent
link
highlighting
potential
biopsychosocial
intervention
targets.
