A neural pathway for social modulation of spontaneous locomotor activity (SoMo-SLA) in Drosophila

Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 121(9)

Опубликована: Фев. 23, 2024

Social enrichment or social isolation affects a range of innate behaviors, such as sex, aggression, and sleep, but whether there is shared mechanism not clear. Here, we report neural underlying modulation spontaneous locomotor activity (SoMo-SLA), an internal-driven behavior indicative internal states. We find that specifically reduces in male flies. identify neuropeptides Diuretic hormone 44 (DH44) Tachykinin (TK) to be up- down-regulated by necessary for SoMo-SLA. further demonstrate sexually dimorphic circuit, which the male-specific P1 neurons encoding states form positive feedback with interneurons coexpressing doublesex ( dsx ) Tk promote locomotion, while also negative DH44 inhibit locomotion. These two opposing neuromodulatory recurrent circuits represent potentially common underlies regulation multiple behaviors.

Язык: Английский

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Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies

Aging, Год журнала: 2023, Номер unknown

Опубликована: Фев. 27, 2023

The astrocyte-neuron lactate shuttle hypothesis posits that glial-generated is transported to neurons fuel metabolic processes required for long-term memory. Although studies in vertebrates have revealed shuttling important cognitive function, it uncertain if this form of coupling conserved invertebrates or influenced by age. Lactate dehydrogenase (Ldh) a rate limiting enzyme interconverts and pyruvate. Here we genetically manipulated expression Drosophila melanogaster (dLdh) glia assess the impact altered metabolism on invertebrate aging courtship memory at different ages. We also assessed survival, negative geotaxis, brain neutral lipids (the core component lipid droplets) metabolites. Both upregulation downregulation dLdh resulted decreased survival impairment with Glial caused age-related without altering while upregulated glial lowered disrupting neuronal increased accumulation. provide evidence age affects tricarboxylic acid (TCA) cycle, 2-hydroxyglutarate (2HG), Collectively, our findings indicate direct alteration either but only an age-dependent manner.

Язык: Английский

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Plasticity in expression of fruit fly larval feeding clusters in response to changes in food quality and distribution

Insectes Sociaux, Год журнала: 2024, Номер 71(1), С. 5 - 15

Опубликована: Фев. 1, 2024

Язык: Английский

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Temporal genomics in Hawaiian crickets reveals compensatory intragenomic coadaptation during adaptive evolution

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Июнь 12, 2024

Abstract Theory predicts that compensatory genetic changes reduce negative indirect effects of selected variants during adaptive evolution, but evidence is scarce. Here, we test this in a wild population Hawaiian crickets using temporal genomics and high-quality chromosome-level cricket genome. In population, mutation, flatwing , silences males rapidly spread due to an acoustically-orienting parasitoid. Our sampling spanned social transition which fixed the went silent. We find long-range linkage disequilibrium around putative locus was maintained over time, hitchhiking genes had functions related -associated effects. develop combinatorial enrichment approach transcriptome data for compensatory, intragenomic coevolution. Temporal genomic selection were distributed genome-wide functionally associated with population’s silence, particularly behavioural responses silent environments. results demonstrate how ‘adaptation begets adaptation’; sociogenetic environment accompanying rapid trait evolution can generate provoking further, adaptation.

Язык: Английский

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Ageing effects of social environments in ‘non-social’ insects

Philosophical Transactions of the Royal Society B Biological Sciences, Год журнала: 2024, Номер 379(1916)

Опубликована: Окт. 28, 2024

It is increasingly clear that social environments have profound impacts on the life histories of ‘non-social’ animals. However, it not yet well known how species with varying degrees sociality respond to different contexts and whether such effects are sex-specific. To survey extent which specifically affect lifespan ageing in non-social species, we performed a systematic literature review, focusing invertebrates but excluding eusocial insects. We found 80 studies or parameters were measured relation changes same-sex opposite-sex exposure, group size cues thereof. Most focused manipulations adults, often reporting sex differences following exposure opposite sex. Some highlighted developmental partner age lifespan. Several explored potential underlying mechanisms, emphasizing insects could provide excellent opportunities interrogate basis ageing. discuss what these can tell us about environment as stressor, trade-offs resources prompted by contexts. suggest fruitful avenues for further research across wider more diverse range taxa. This article part discussion meeting issue ‘Understanding society using natural populations’.

Язык: Английский

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Peptidergic neurons with extensive branching orchestrate the internal states and energy balance of male Drosophila melanogaster.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 5, 2024

ABSTRACT Neuropeptide SIFamide (SIFa) neurons in Drosophila melanogaster have been characterized by their exceptionally elaborate arborization patterns, which extend from the brain into ventral nerve cord (VNC). SIFa are equipped to receive signals that integrate both internal physiological cues and external environmental stimuli. These enable regulate energy balance, sleep metabolic status, circadian timing. peptidergic instrumental orchestrating animal’s states refining its behavioral responses, yet precise molecular underpinnings of this process remain elusive. Here we demonstrate coordinate a range responses selectively integrating inputs outputs context-dependent manner. engage feedback loop with sNPF cord, modifying behaviors such as long mating duration (LMD) shorter (SMD). Furthermore, essential neuropeptides Dsk, sNPF, dilp2, interval timing behaviors. Activating leads reduced increased food intake, while deactivating them reduces intake. Overall, these findings importance absorbing turning outputs, shedding light on intricate orchestration.

Язык: Английский

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Recovery from social isolation requires dopamine in males, but not the autism-related gene nlg3 in either sex

Royal Society Open Science, Год журнала: 2024, Номер 11(7)

Опубликована: Июль 1, 2024

Social isolation causes profound changes in social behaviour a variety of species. However, the genetic and molecular mechanisms modulating behavioural responses to recovery remain be elucidated. Here, we quantified response vinegar flies using two distinct protocols (social space preference sociability, spontaneous tendencies form groups). We found that increased reduced sociability. These effects were reversible could after 3 days group housing. Flies with loss function neuroligin3 (orthologue autism-related neuroligin genes) known socially enriched environment still able recover from isolation. also show dopamine (DA) is needed for males but not females. Furthermore, only males, DA levels are recovered Finally, mutant , propose model explain how involved its dynamic sex-specific manner.

Язык: Английский

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On the use of kinship and familiarity associated social information in mediating Drosophila melanogaster oviposition decisions

PLoS ONE, Год журнала: 2025, Номер 20(3), С. e0320377 - e0320377

Опубликована: Март 26, 2025

Decisions where an individual lays their eggs are important, as the choice may affect offspring’s survival and lifetime reproductive success. Information produced by conspecifics can potentially be useful in making decisions this “social information” provide energetically cheaper means of assessing oviposition site suitability rather than acquiring it personally. However, not all public information equally beneficial, cues kin especially valuable they might signal suitable microenvironments, associated with other fitness advantages resulting from improved foraging success and/or a decreased risk competition/cannibalism compared to sites unrelated located. Using fruit fly, Drosophila melanogaster , we explored whether use is kin-based egg-laying decisions. Kinship recognized several ways, including environmentally-associated proxy cues, so there were biases how focal females interacted that differed both genetic relatedness, environmental “familiarity.” In series inter-connected assays, examined behaviour potential substrates manner prior conspecific exposure, counted offspring eclosed these different substrates. Sites had exhibited demonstrators visited more, yielded more unexposed Furthermore, patterns bias production consistent ovipositing exhibiting sensitivity kinship status substrate’s occupants. The basis categorization appears based on phenotypes reflect true but nature social affected factors. These results further highlight usefulness D. model understand evolution expression decision-making.

Язык: Английский

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Flexibility of neural circuits regulating mating behaviors in mice and flies

Frontiers in Neural Circuits, Год журнала: 2022, Номер 16

Опубликована: Ноя. 8, 2022

Mating is essential for the reproduction of animal species. As mating behaviors are high-risk and energy-consuming processes, it critical animals to make adaptive decisions. This includes not only finding a suitable mate, but also adapting animal’s needs environmental conditions. Internal include physical states (e.g., hunger) emotional fear), while external conditions both social cues existence predators or rivals) non-social factors food availability). With recent advances in behavioral neuroscience, we now beginning understand neural basis behaviors, particularly genetic model organisms such as mice flies. However, how internal integrated by nervous system enable mating-related decision-making state- context-dependent manner less well understood. In this article, review knowledge regarding flexible from studies flies mice. By contrasting derived these two evolutionarily distant organisms, discuss potential conserved divergent mechanisms involved control invertebrate vertebrate brains.

Язык: Английский

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Neuroregulation of foraging behavior mediated by the olfactory co-receptor Orco in termites

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 262, С. 129639 - 129639

Опубликована: Фев. 7, 2024

Язык: Английский

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