20 Years of Providing Custom Non-Animal-Derived Antibodies — A Review

Alternatives to Laboratory Animals, Год журнала: 2025, Номер unknown

Опубликована: Апрель 17, 2025

As innovators who made non-animal-derived antibodies available to researchers starting 20 years ago, we have generated more than 60,000 during this time span. Here, review and highlight the key challenges that hampered adoption of research by phage display. We describe advantages method over traditional immunisation-based methods, provide examples specific projects. active participants in attesting scientific validity antibodies, contributed supported advancements display for generation antibodies. Such paved way community switch animal-free at a faster pace, as goal near future.

Язык: Английский

Global availability of critical reagents for biologicals testing - Current status, challenges and possible solutions

Biologicals, Год журнала: 2025, Номер 90, С. 101821 - 101821

Опубликована: Март 22, 2025

On July 2, 2024, the International Alliance for Biological Standardization (IABS) and Humane Society (HSI) co-hosted a webinar on global availability affordability of critical reagents vaccine biologics production. Despite growing support non-animal testing, significant barriers remain, especially in low-income countries facing financial supply chain challenges. This meeting showcased successful collaborations reagent production shared industry regulatory perspectives. Key included high costs, import complexities, limited number suppliers. Participants stressed need tailored risk-based in-house assay validation, stronger collaboration standardised testing. The idea regional hubs Africa Southeast Asia distribution was also discussed to address logistical A central theme advocating reliance strategies, which promote assessments resource optimisation, as demonstrated by EU/EEA OCABR Network activities South African-European laboratory collaborations. Difficulties smaller national control laboratories international standards were highlighted, along with further innovation non-animal-derived these importance continued adopting practices improve access ensure sustainability

Язык: Английский

Human antibodies neutralizing the alpha-latrotoxin of the European black widow

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Июнь 12, 2024

Poisoning by widow-spider (genus

Язык: Английский