International Journal of Pharmaceutics,
Год журнала:
2023,
Номер
648, С. 123561 - 123561
Опубликована: Окт. 30, 2023
3D
Printing
(3DP)
of
pharmaceuticals
could
drastically
transform
the
manufacturing
medicines
and
facilitate
widespread
availability
personalised
healthcare.
However,
with
increasing
awareness
environmental
damage
manufacturing,
3DP
must
be
eco-friendly,
especially
when
it
comes
to
carbon
emissions.
This
study
investigated
effects
pharmaceutical
3DP.
Using
Design
Experiments
(DoE)
Machine
Learning
(ML),
we
looked
at
energy
use
in
Fused
Deposition
Modeling
(FDM).
From
136
experimental
runs
across
four
common
dosage
forms,
identified
several
key
parameters
that
contributed
consumption,
consequently
CO
International Journal of Pharmaceutics X,
Год журнала:
2021,
Номер
3, С. 100087 - 100087
Опубликована: Июль 2, 2021
We
report
here
the
potential
role
of
a
4-strain
probiotic
suspension
for
use
with
patients
Parkinson's
disease
(PD).
Stool
samples
from
group
three
diagnosed
PD
were
used
to
create
microbiotas
in
an
Seminars in Immunopathology,
Год журнала:
2022,
Номер
44(4), С. 485 - 507
Опубликована: Май 10, 2022
Autoimmune
liver
diseases
are
a
group
of
immune-mediated
with
three
distinct
entities,
including
autoimmune
hepatitis,
primary
biliary
cholangitis,
and
sclerosing
cholangitis.
The
interplay
genetic
environmental
factors
leads
to
the
breakdown
self-tolerance,
resulting
in
hyper-responsiveness,
auto-aggressive
immune
activation.
Emerging
evidence
links
alterations
commensal
microbiome
configuration
aberrant
system
activation
by
microbial
signals,
mainly
via
gut-liver
axis.
Thus,
is
new
frontier
deepen
pathogenetic
understanding,
uncover
biomarkers,
inspire
innovative
treatments.
Herein,
we
review
current
on
role
from
both
clinical
basic
research.
We
highlight
recent
achievements
also
bottlenecks
limitations.
Moreover,
give
an
outlook
future
developments
potential
for
applications.
Natural Product Reports,
Год журнала:
2023,
Номер
40(6), С. 1078 - 1093
Опубликована: Янв. 1, 2023
Covering:
2014
to
June
2022The
gut
microbiota
has
attracted
increasing
attention
from
researchers
due
its
critical
role
in
regulating
human
physiology
and
pathophysiology.
Natural
products
(NPs)
produced
or
transformed
by
microbes
are
key
signalling
mediators
for
a
variety
of
physiological
functions.
On
the
other
hand,
NPs
ethnomedicines
have
also
been
found
generate
health
benefits
through
modulation
microbiota.
In
this
highlight,
we
review
most
recent
studies
related
microbiota-derived
bioactive
that
regulate
pathological
processes
via
microbiota-associated
mechanisms.
We
outline
strategies
discovery
methodologies
how
elucidate
crosstalk
between
Microorganisms,
Год журнала:
2024,
Номер
12(2), С. 242 - 242
Опубликована: Янв. 24, 2024
Orally
administered
compounds
represent
the
great
majority
of
all
pharmaceutical
produced
for
human
use
and
are
most
popular
among
patients
since
they
practical
easy
to
self-administer.
Following
ingestion,
orally
drugs
begin
a
“perilous”
journey
down
gastrointestinal
tract
their
bioavailability
is
modulated
by
numerous
factors.
The
(GI)
anatomy
can
modulate
drug
accounts
interpatient
response
heterogeneity.
Furthermore,
host
genetics
contributor
modulation.
Importantly,
component
GI
that
has
been
gaining
notoriety
with
regard
treatment
interactions
gut
microbiota,
which
shares
two-way
interaction
in
be
influenced
able
influence
drugs.
Overall,
patient-friendly
option.
However,
during
tract,
there
factors
patient-specific
manner.
Medicine in Novel Technology and Devices,
Год журнала:
2024,
Номер
23, С. 100319 - 100319
Опубликована: Июль 2, 2024
The
convergence
of
artificial
intelligence
(AI)
and
microbial
therapeutics
offers
promising
avenues
for
novel
discoveries
therapeutic
interventions.
With
the
exponential
growth
omics
datasets
rapid
advancements
in
AI
technology,
next
generation
is
increasingly
prevalent
microbiology
research.
In
research,
instrumental
classification
functional
annotation
microorganisms.
Machine
learning
algorithms
facilitate
efficient
accurate
categorization
taxa,
enabling
identification
traits
metabolic
pathways
within
communities.
Additionally,
AI-driven
protein
design
strategies
hold
promise
engineering
enzymes
with
enhanced
catalytic
activities
stabilities.
By
predicting
structures,
functions,
interactions,
enable
rational
proteins
tailored
specific
applications.
systems
are
already
present
clinical
laboratories
form
expert
rules
used
by
some
automated
susceptibility
testing
systems.
future,
technologists
will
rely
more
heavily
on
initial
screening,
allowing
them
to
focus
diagnostic
challenges
complex
technical
interpretations.
approaches
immense
advancing
our
understanding
ecosystems,
accelerating
drug
discovery
processes,
fostering
development
groundbreaking
This
review
aims
summarize
common
their
applications
synthetic
biology.
We
provide
a
comprehensive
evaluation
AI's
utility
discussing
both
its
advantages
challenges.
Finally,
we
explore
future
research
directions
bottlenecks
faced
field.
Pharmaceutics,
Год журнала:
2021,
Номер
13(7), С. 1026 - 1026
Опубликована: Июль 6, 2021
The
human
gut
microbiome,
composed
of
trillions
microorganisms,
plays
an
essential
role
in
health.
Many
factors
shape
microbiome
composition
over
the
life
span,
including
changes
to
diet,
lifestyle,
and
medication
use.
Though
not
routinely
tested
during
drug
development,
drugs
can
exert
profound
effects
on
potentially
altering
its
functions
promoting
disease.
This
study
develops
a
machine
learning
(ML)
model
predict
whether
will
impair
growth
40
bacterial
strains.
Trained
18,600
drug-bacteria
interactions,
13
distinct
ML
models
are
built
compared,
tree-based,
ensemble,
artificial
neural
network
techniques.
Following
hyperparameter
tuning
multi-metric
evaluation,
lead
is
selected:
tuned
extra
trees
algorithm
with
performances
AUROC:
0.857
(±0.014),
recall:
0.587
(±0.063),
precision:
0.800
(±0.053),
f1:
0.666
(±0.042).
be
used
by
pharmaceutical
industry
development
could
even
adapted
for
use
clinical
settings.
