Inferior social hierarchy is vulnerable to anxiety-like behavior in chronic pain mice: Potential role of gut microbiota and metabolites

Neurobiology of Disease, Год журнала: 2024, Номер 191, С. 106402 - 106402

Опубликована: Янв. 4, 2024

Social dominance is a universal phenomenon among grouped animals that profoundly affects survival, health, and reproductive success by determining access to resources, exerting powerful influence on subsequent behavior. However, the understanding of pain anxiety comorbidities in dominant or subordinate suffering from chronic not well-defined. Here, we provide evidence mice are more susceptible pain-induced compared mice. We propose gut microbiota may play mediating role this mechanism. Our findings demonstrate transplantation fecal with inflammatory pain, but mice, into antibiotics-treated pseudo-germ-free significantly amplifies anxiety-like phenotypes, highlighting critical involvement behavioral response. Using model, carried out 16S rRNA sequencing untargeted metabolomic analyses explore relationship between metabolites stable social hierarchy Interestingly, behaviors were directly associated some microbial genera metabolites, especially bile acid metabolism. Overall, have demonstrated close status susceptibility, contributions high-anxiety state pain.

Язык: Английский

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MicrobeTCM: a comprehensive platform for the interactions of microbiota and traditional Chinese medicine

Pharmacological Research, Год журнала: 2024, Номер unknown, С. 107080 - 107080

Опубликована: Янв. 1, 2024

Thanks to the advancements in bioinformatics, drugs, and other interventions that modulate microbes treat diseases have been emerging continuously. In recent years, an increasing number of databases related traditional Chinese medicine (TCM) gut established. However, a database combining two has not yet developed. To accelerate TCM research address micro ecological system connection between short board, we developed most comprehensive micro-ecological TCM. This initiative includes standardization following advantages: (1) A repeatable process achieved through retrieval strategy identify literature. involved identifying 419 experiment articles from PubMed six authoritative databases; (2) High-quality data integration double-entry extraction literature, mitigating uncertainties associated with natural language extraction; (3) Implementation similar aiding prediction mechanisms action. Leveraging drug similarity, target entity known drug-target association, our platform enables effects new or acupoint prescription using existing data. total, MicrobeTCM 171 diseases, 725 microbes, 1468 herb-formulas, 1032 herbs, 15780 chemical compositions, 35 acupoint-formulas, 77 acupoints. For further exploration, please visit https://www.microbetcm.com.

Язык: Английский

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Polysaccharides extracted from common buckwheat (Fagopyrum esculentum) attenuate cognitive impairment via suppressing RAGE/p38/NF-κB signaling and dysbiosis in AlCl3-treated rats

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 276, С. 133898 - 133898

Опубликована: Июль 15, 2024

Язык: Английский

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Meta-analysis of the human gut microbiome uncovers shared and distinct microbial signatures between diseases

mSystems, Год журнала: 2024, Номер 9(8)

Опубликована: Июль 30, 2024

Microbiome studies have revealed gut microbiota's potential impact on complex diseases. However, many often focus one disease per cohort. We developed a meta-analysis workflow for microbiome profiles and analyzed shotgun metagenomic data covering 11 Using interpretable machine learning differential abundance analysis, our findings reinforce the generalization of binary classifiers Crohn's (CD) colorectal cancer (CRC) to hold-out cohorts highlight key microbes driving these classifications. identified high microbial similarity in pairs like CD vs ulcerative colitis (UC), CRC, Parkinson's type 2 diabetes (T2D), schizophrenia T2D. also found strong inverse correlations Alzheimer's UC. These findings, detected by pipeline, provide valuable insights into

Язык: Английский

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Gut microbiota metabolites: potential therapeutic targets for Alzheimer’s disease?

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Сен. 17, 2024

Background Alzheimer’s disease (AD) is a neurodegenerative characterized by progressive decline in cognitive function, which significantly increases pain and social burden. However, few therapeutic interventions are effective preventing or mitigating the progression of AD. An increasing number recent studies support hypothesis that gut microbiome its metabolites may be associated with upstream regulators AD pathology. Methods In this review, we comprehensively explore potential mechanisms currently available targeting for improvement Our discussion structured around modern research advancements AD, bidirectional communication between brain, multi-target regulatory effects microbial on strategies aimed at modulating microbiota to manage Results The plays crucial role pathogenesis through continuous via microbiota-gut-brain axis. Among these, such as lipids, amino acids, bile acids neurotransmitters, especially sphingolipids phospholipids, serve central components gut-brain axis, regulating AD-related pathogenic including β-amyloid metabolism, Tau protein phosphorylation, neuroinflammation. Additionally, probiotic administration, fecal transplantation, antibiotic use have also provided evidence supporting association At same time, propose an innovative strategy treating AD: healthy lifestyle combined targeted probiotics other interventions, aiming restore intestinal ecology balance. Conclusion Despite previous efforts, molecular microbes act yet fully described. microorganisms become essential target connecting axis improving symptoms it requires joint exploration multiple centers disciplines.

Язык: Английский

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