Disruptions of Gut Microbiota are Associated with Cognitive Deficit of Preclinical Alzheimer's Disease: A Cross-Sectional Study DOI
Binbin Yu,

Guomeng Wan,

Shupeng Cheng

и другие.

Current Alzheimer Research, Год журнала: 2023, Номер 20(12), С. 875 - 889

Опубликована: Дек. 1, 2023

Background: Alzheimer's Disease (AD) is the most prevalent type of dementia. The early change gut microbiota a potential biomarker for preclinical AD patients. Objective: study aimed to explore changes in characteristics patients, including those with Subjective Cognitive Decline (SCD) and Mild Impairment (MCI), detect correlation between cognitive performances. Methods: This included 117 participants [33 MCI, 54 SCD, 30 Healthy Controls (HC)]. We collected fresh fecal samples blood from all evaluated their performance. analyzed diversity structure through qPCR, screened characteristic microbial species machine learning models, explored correlations these performances serum indicators. Results: Compared healthy controls, MCI SCD patients was significantly different. three microorganisms, Bacteroides ovatus, Bifidobacterium adolescentis, Roseburia inulinivorans, were based on best classification model (HC MCI) having intergroup differences. adolescentis associated better performance multiple scores several inulinivorans showed negative Functional Activities Questionnaire (FAQ). Conclusion: has changed terms composition richness. Correlations have been discovered Gut alterations shown promise affecting pathology deficit.

Язык: Английский

Disruptions of Gut Microbiota are Associated with Cognitive Deficit of Preclinical Alzheimer's Disease: A Cross-Sectional Study DOI
Binbin Yu,

Guomeng Wan,

Shupeng Cheng

и другие.

Current Alzheimer Research, Год журнала: 2023, Номер 20(12), С. 875 - 889

Опубликована: Дек. 1, 2023

Background: Alzheimer's Disease (AD) is the most prevalent type of dementia. The early change gut microbiota a potential biomarker for preclinical AD patients. Objective: study aimed to explore changes in characteristics patients, including those with Subjective Cognitive Decline (SCD) and Mild Impairment (MCI), detect correlation between cognitive performances. Methods: This included 117 participants [33 MCI, 54 SCD, 30 Healthy Controls (HC)]. We collected fresh fecal samples blood from all evaluated their performance. analyzed diversity structure through qPCR, screened characteristic microbial species machine learning models, explored correlations these performances serum indicators. Results: Compared healthy controls, MCI SCD patients was significantly different. three microorganisms, Bacteroides ovatus, Bifidobacterium adolescentis, Roseburia inulinivorans, were based on best classification model (HC MCI) having intergroup differences. adolescentis associated better performance multiple scores several inulinivorans showed negative Functional Activities Questionnaire (FAQ). Conclusion: has changed terms composition richness. Correlations have been discovered Gut alterations shown promise affecting pathology deficit.

Язык: Английский

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