Опубликована: Янв. 1, 2024
Язык: Английский
Expert Review of Cardiovascular Therapy, Год журнала: 2025, Номер unknown, С. 1 - 12
Опубликована: Фев. 7, 2025
The pathophysiology of cardiovascular diseases encompasses a complex interplay genetic and environmental risk factors. Even if traditional factors are treated to target, there remains residual risk. This manuscript reviews the potential role gut microbiota in development disease, as target. A systematic search was conducted until 30 October 2024 on PubMed (MEDLINE), using MeSH terms [Gut microbiota] + [Dysbiosis] [Cardiovascular] [TMAO] [bile acids] [short-chain fatty acids]. term dysbiosis implies changes equilibrium, with modifications composition functionality series additional factors: reduced diversity uniformity microorganisms; short-chain acid-producing bacteria; increased permeability; release metabolites, such trimethylamine N-oxide, betaine, phenylalanine, tryptophan-kynurenine, phenylacetylglutamine, lipopolysaccharides; secondary bile acid excretion, leading inflammation, oxidative stress, endothelial dysfunction facilitating onset pathological conditions, including obesity, hypertension, diabetes, atherosclerosis, heart failure. Attempts restore balance through different interventions, mainly diet, have been shown positively affect individual components metabolites reduce disease. In addition, probiotics prebiotics potentially useful. Fecal transplantation is promising therapy.
Язык: Английский
Процитировано
1
Gut Microbes, Год журнала: 2024, Номер 16(1)
Опубликована: Окт. 24, 2024
The current studies have shown that the occurrence and development of chronic obstructive pulmonary disease (COPD) are closely related to changes in gut health its microenvironment, even some diseases significant clinical correlation with COPD. dysbiosis microbiota observed COPD patients also suggests a potential bidirectional interaction between lung. Communication lung may occur through circulating inflammatory cells, microbial metabolites, mediators, but mechanism communication is still under study. Therefore, more research needed this area. In review, we summarize recent animal models on role gut-lung axis mechanisms, so as provide ideas for further field. addition, summarized negative effects medication risk factors proposed prevention treatment strategies.
Язык: Английский
Процитировано
4
The International Journal of Artificial Organs, Год журнала: 2025, Номер unknown
Опубликована: Янв. 29, 2025
Cardiopulmonary bypass (CPB) is an indispensable technique in cardiac surgery; however, its impact on gut microbiota and metabolites remains insufficiently studied. CPB may disrupt the intestinal mucosal barrier, altering composition function of microbiota, thereby triggering local immune responses systemic inflammation, which lead to postoperative complications. This narrative review examines relevant literature from PubMed, Web Science, Google Scholar, CNKI databases over past decade. Keywords such as “gut microbiota,” “cardiopulmonary bypass,” “cardiac surgery,” “postoperative complications” were employed, with Boolean operators used refine search results. The changes before after CPB, their role complications, potential strategies for modulation improve outcomes.
Язык: Английский
Процитировано
0
CABI eBooks, Год журнала: 2025, Номер unknown, С. 80 - 99
Опубликована: Март 24, 2025
Язык: Английский
Процитировано
0
Clinical Reviews in Allergy & Immunology, Год журнала: 2025, Номер 68(1)
Опубликована: Апрель 11, 2025
Язык: Английский
Процитировано
0
European journal of medical research, Год журнала: 2024, Номер 29(1)
Опубликована: Апрель 15, 2024
Abstract Background Atrial fibrillation (AF) is associated with circulating inflammation. Short-chain fatty acids (SCFAs) derived from gut microbiota (GM) regulate leukocyte function and inhibit the release of inflammatory cytokines, which are partly mediated by G-protein-coupled receptor 43 (GPR43) signaling. This study aimed to investigate expression GPR43/NOD-like receptors family pyrin domain containing 3 (NLRP3) in leukocytes interaction intestinal SCFAs levels AF patients. Methods Expressions GPR43 NLRP3 mRNA peripheral blood 23 patients 25 non-AF controls were detected quantitative reverse transcription-polymerase chain reaction (qRT-PCR). protein evaluated western blot analysis. The plasma IL-1β measured enzyme-linked immunosorbent assay (ELISA). fecal based on GC/MS metabolome corresponding 21 14 acquired our published dataset. To evaluate IL-1β, human THP-1 cells stimulated or without (acetate, propionate, butyrate), lipopolysaccharide (LPS), nigericin vitro, respectively. Results Compared controls, was significantly reduced ( P = 0.011) coupled increase downstream 0.007) < 0.001), consistent changes expression. Furthermore, positively correlated GM-derived acetic acid 0.046) negatively 0.024). In contrast negative correlation between left atrial diameter (LAD) 0.008), LAD Subsequent mediation analysis showed that 68.88% total effect might be GPR43/NLRP3. constructed GPR43–NLRP3 score have a predictive potential for detection (AUC 0.81, 0.001). Moreover, treatment increased remarkably LPS/nigericin-induced vitro. Conclusions Disrupted interactions leukocytes, SCFAs, especially acid, may involved development enlargement enhancing
Язык: Английский
Процитировано
1
Biomedicines, Год журнала: 2024, Номер 12(8), С. 1645 - 1645
Опубликована: Июль 24, 2024
Cardiovascular diseases (CVDs) are the most common cause of mortality and morbidity in Western countries, thus representing a global health concern. CVDs show different patterns terms prevalence presentation men women. The role sex hormones has been extensively implicated these sex-specific differences, due to presence menstrual cycle menopause Moreover, gut microbiota (GM) cardiovascular health, considering growing evidence that it is involved determining development specific diseases. In particular, gut-derived metabolites have linked kidney disorders, which can turn promote progression CVDs. Considering differences composition GM between women, possible act as mediator regard disparities This narrative review aims comprehensively interplay sex, GM, CVDs, discussing potential mechanisms therapeutic options.
Язык: Английский
Процитировано
1
Cureus, Год журнала: 2024, Номер unknown
Опубликована: Окт. 5, 2024
Cardiovascular diseases (CVDs) remain the leading cause of morbidity and mortality worldwide despite advances in medical research therapeutics. Emerging evidence suggests a significant role gut-brain axis, complex communication network involving gut microbiota, central nervous system, cardiovascular modulating health. The microbiota influences systemic inflammation, neurohumoral pathways, metabolic processes, which are critical pathogenesis CVD. Dysbiosis, or an imbalance has been implicated various conditions, including hypertension, atherosclerosis, heart failure. This comprehensive review aims to elucidate intricate relationship between microbiome, brain, highlighting mechanisms by gut-derived signals affect function. Key microbial metabolites, such as short-chain fatty acids (SCFAs) trimethylamine N-oxide (TMAO), their impact on vascular health blood pressure regulation discussed. Furthermore, explores potential therapeutic strategies targeting probiotics, prebiotics, dietary modifications, pharmacological interventions, improve outcomes. Despite promising findings, field faces challenges individual variability microbiome composition, complexities interactions, need for robust clinical trials establish causality. Addressing these through interdisciplinary could pave way innovative, personalized approaches. provides understanding gut-brain-cardiovascular underscoring its novel target preventing treating
Язык: Английский
Процитировано
1
Frontiers in Cardiovascular Medicine, Год журнала: 2024, Номер 11
Опубликована: Окт. 11, 2024
Despite significant advances in diagnosis and treatment over recent decades, cardiovascular disease (CVD) remains one of the leading causes morbidity mortality Western countries. This persistent burden is partly due to incomplete understanding fundamental pathogenic mechanisms, which limits effectiveness current therapeutic interventions. In this context, evidence highlights pivotal role immuno-inflammatory activation by gut microbiome influencing disorders, potentially opening new avenues. Indeed, while atherosclerosis has been established as a chronic inflammatory arterial wall, accumulating data suggest that immune system regulation anti-inflammatory pathways mediated microbiota metabolites play crucial range CVDs, including heart failure, pericardial disease, arrhythmias, cardiomyopathies. Of particular interest emerging how tryptophan metabolism-by both host microbiota-converges on Aryl hydrocarbon Receptor (AhR), key regulator homeostasis. review seeks enhance our inflammation CVD, with focus microbiome-derived metabolites, such indoles their derivatives, contribute cardioimmunopathology. By exploring these we aim facilitate development novel, microbiome-centered strategies for combating CVD.
Язык: Английский
Процитировано
1
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0