Effect of melatonin on gut microbiome and metabolomics in diabetic cognitive impairment DOI Creative Commons
Ming Gao, Jie Li, Xu Han

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Ноя. 21, 2024

Diabetic cognitive impairment(DCI) presents as a central nervous complication of diabetes especially among aging population. Melatonin (MEL) is known for its antioxidant and anti-inflammation effects in neuroprotective aspects. Recent evidence has demonstrated that the gut microbiome plays key role DCI by modulating function through gut-brain crosstalk. MEL been shown to modulate microbiota composition diabetic model. However, underlying mechanism which contributes remains unclear. This study aims investigate effect attenuating relation regulating metabolomics. Cognitive memory were assessed Morris water maze test, histopathological assessment brain tissues, immunoblotting neuroinflammation apoptosis. The levels serum tumor necrosis factor-α (TNF-α) Interleukin-18 (IL-18) measured enzyme-linked immunoassays reflect circulatory inflammation level.16S rRNA sequencing analysis was performed on control mice(db-m group), mice(db-db group) MEL-treated mice(db-dbMEL group). Gut metabolites changes characterized using liquid chromatography tandem mass spectrometry (LC-MS/MS). Our confirmed alleviated diabetes-induced cognition dysfunction. protected against apoptosis hippocampus db-db mice. corrected increased abundance Bacteroides Dorea reduced Prevotella vast majority differential three groups lipids lipid-like molecules. significantly restored pyruvate lactic acid. results supported use promising therapeutic agent DCI, may be associated with metabolomics regulation.

Язык: Английский

The Role of Gut Microbiota-Derived Trimethylamine N-Oxide in the Pathogenesis and Treatment of Mild Cognitive Impairment DOI Open Access
Haihua Xie, Jia‐Qian Jiang,

Sihui Cao

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(3), С. 1373 - 1373

Опубликована: Фев. 6, 2025

Mild cognitive impairment (MCI) represents a transitional stage between normal aging and dementia, often considered critical for dementia prevention. Despite its significance, no effective clinical treatment MCI has yet been established. Emerging evidence demonstrated strong association trimethylamine-N-oxide (TMAO), prominent metabolite derived from the gut microbiota, MCI, highlighting potential as biomarker therapeutic target. TMAO implicated in increasing risk through influence on factors such hypertension, cardiovascular disease, depression, diabetes, stroke. Moreover, it contributes to by promoting oxidative stress, disrupting blood–brain barrier, impairing synaptic plasticity, inducing inflammation, causing mitochondrial metabolic disturbances, facilitating abnormal protein aggregation. This review further explores strategies targeting mitigate progression.

Язык: Английский

Процитировано

0
A panel of altered blood oxysterols in patients with mild cognitive impairment: A novel combined diagnostic marker DOI Creative Commons
Yu An, Yuandi Xi, Tao Wang

и другие.

Pharmacological Research, Год журнала: 2025, Номер 213, С. 107661 - 107661

Опубликована: Фев. 20, 2025

Perturbed cholesterol metabolism may play an important role in the development of dementia and its preclinical stage, mild cognitive impairment (MCI). Oxysterols, metabolites generated during oxidation, also appear to be risk factors for MCI. Therefore, we aimed investigate if metabolic profile blood oxysterols could used characterize MCI risk. This cross-sectional study incorporated 501 participants-253 patients with 248 cognitively normal controls. Serum levels 22 free were measured, a set 27 oxysterol-related gene polymorphisms was genotyped. Five [27-hydroxycholesterol (27-OHC), 27-OHC periphery-derived metabolite 3β-hydroxy-5-cholestenoic acid (27-CA) brain-derived 7α-hydroxy-3-oxo-4-cholestenoic (7-HOCA), 4β-hydroxycholesterol (4β-OHC); 4α-hydroxycholesterol (4α-OHC)] twenty-two detected serum significantly differed between controls, greatly distinguishing from control individuals (AUC=0.834, 95% CI: 0.804-0.866). Association analyses demonstrated significant correlations these candidate oxysterol biomarkers younger age, higher lipids, worse performance, monounsaturated fatty intake. panel as highlighted essential pathogenesis early prevention. (The registered Chinese Clinical Trial Registry ChiCTR-OOC-17011882).

Язык: Английский

Процитировано

0
High-cellulose diet ameliorates cognitive impairment by modulating gut microbiota and metabolic pathways in mice DOI
Moeka Tanabe, Kazuo Kunisawa, Isao Saito

и другие.

Journal of Nutrition, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
The Intersection of Ultra-Processed Foods, Neuropsychiatric Disorders, and Neurolaw: Implications for Criminal Justice DOI Creative Commons
Susan L. Prescott, Kathleen F. Holton, Christopher A. Lowry

и другие.

NeuroSci, Год журнала: 2024, Номер 5(3), С. 354 - 377

Опубликована: Сен. 23, 2024

Over the last decade there has been increasing interest in links between consumption of ultra-processed foods and various neuropsychiatric disorders, aggression, antisocial behavior. Neurolaw is an interdisciplinary field that seeks to translate rapid voluminous advances brain science into legal decisions policy. An enhanced understanding biophysiological mechanisms by which influence behavior allows for a historical reexamination one forensic neuropsychiatry's most famous cases-

Язык: Английский

Процитировано

2
Effect of melatonin on gut microbiome and metabolomics in diabetic cognitive impairment DOI Creative Commons
Ming Gao, Jie Li, Xu Han

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Ноя. 21, 2024

Diabetic cognitive impairment(DCI) presents as a central nervous complication of diabetes especially among aging population. Melatonin (MEL) is known for its antioxidant and anti-inflammation effects in neuroprotective aspects. Recent evidence has demonstrated that the gut microbiome plays key role DCI by modulating function through gut-brain crosstalk. MEL been shown to modulate microbiota composition diabetic model. However, underlying mechanism which contributes remains unclear. This study aims investigate effect attenuating relation regulating metabolomics. Cognitive memory were assessed Morris water maze test, histopathological assessment brain tissues, immunoblotting neuroinflammation apoptosis. The levels serum tumor necrosis factor-α (TNF-α) Interleukin-18 (IL-18) measured enzyme-linked immunoassays reflect circulatory inflammation level.16S rRNA sequencing analysis was performed on control mice(db-m group), mice(db-db group) MEL-treated mice(db-dbMEL group). Gut metabolites changes characterized using liquid chromatography tandem mass spectrometry (LC-MS/MS). Our confirmed alleviated diabetes-induced cognition dysfunction. protected against apoptosis hippocampus db-db mice. corrected increased abundance Bacteroides Dorea reduced Prevotella vast majority differential three groups lipids lipid-like molecules. significantly restored pyruvate lactic acid. results supported use promising therapeutic agent DCI, may be associated with metabolomics regulation.

Язык: Английский

Процитировано

2