Photoelectrochemical Biosensor Based on TiO2/P5FIn with a Cascade Amplification Strategy for Simultaneous Detection of GSH and E2 Analytes of Ovarian Cancer DOI
Lu Zhang, Dandan Liu,

Anding Wang

и другие.

Analytical Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 17, 2025

In this work, a photoelectrochemical (PEC) sensor for ovarian cancer detection was constructed based on TiO2/poly(5-formylindole) (P5FIn)heterojunction using cascade amplification. The combined of multiple markers instead single mode can improve diagnostic accuracy. photoelectron conversion efficiency and photocurrent response were significantly improved by the reaction detector glutathione (GSH) with cystine. 17β-Estradiol (E2) had negative effect PEC response, reducing signal, ultimately realizing sensitive GSH E2. good performance E2, linear range (LDR) 0.5–1000 μM, limits (LOD) 0.167 μM 0.1224 pM, respectively, 0.0003671–36.71 nM. Meanwhile, also has analytical capability, signal amplification strategy potential development prospect in disease detection.

Язык: Английский

Photoelectrochemical Biosensor Based on TiO2/P5FIn with a Cascade Amplification Strategy for Simultaneous Detection of GSH and E2 Analytes of Ovarian Cancer DOI
Lu Zhang, Dandan Liu,

Anding Wang

и другие.

Analytical Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 17, 2025

In this work, a photoelectrochemical (PEC) sensor for ovarian cancer detection was constructed based on TiO2/poly(5-formylindole) (P5FIn)heterojunction using cascade amplification. The combined of multiple markers instead single mode can improve diagnostic accuracy. photoelectron conversion efficiency and photocurrent response were significantly improved by the reaction detector glutathione (GSH) with cystine. 17β-Estradiol (E2) had negative effect PEC response, reducing signal, ultimately realizing sensitive GSH E2. good performance E2, linear range (LDR) 0.5–1000 μM, limits (LOD) 0.167 μM 0.1224 pM, respectively, 0.0003671–36.71 nM. Meanwhile, also has analytical capability, signal amplification strategy potential development prospect in disease detection.

Язык: Английский

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