Targeted and intelligent nano-drug delivery systems for colorectal cancer treatment DOI Creative Commons

Meihong Chai,

Shihua Wang, Yuxin Chen

и другие.

Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13

Опубликована: Апрель 25, 2025

Colorectal cancer (CRC) remains a highly heterogeneous malignancy with significant morbidity and mortality worldwide. Despite advancements in surgery, chemotherapy, immunotherapy, targeted therapy, treatment efficacy is often hampered by drug resistance systemic toxicity. In recent years, nano-drug delivery systems (NDDS) have emerged as promising strategy to enhance therapeutic precision, reduce adverse effects, overcome CRC treatment. This review discusses the NDDS for treatment, focusing on optimization of oral systems, development tumor-specific targeting strategies, design intelligent responsive tumor microenvironment (TME). Furthermore, we summarize current challenges translation explore future research directions enhancing their clinical feasibility impact.

Язык: Английский

Targeted and intelligent nano-drug delivery systems for colorectal cancer treatment DOI Creative Commons

Meihong Chai,

Shihua Wang, Yuxin Chen

и другие.

Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13

Опубликована: Апрель 25, 2025

Colorectal cancer (CRC) remains a highly heterogeneous malignancy with significant morbidity and mortality worldwide. Despite advancements in surgery, chemotherapy, immunotherapy, targeted therapy, treatment efficacy is often hampered by drug resistance systemic toxicity. In recent years, nano-drug delivery systems (NDDS) have emerged as promising strategy to enhance therapeutic precision, reduce adverse effects, overcome CRC treatment. This review discusses the NDDS for treatment, focusing on optimization of oral systems, development tumor-specific targeting strategies, design intelligent responsive tumor microenvironment (TME). Furthermore, we summarize current challenges translation explore future research directions enhancing their clinical feasibility impact.

Язык: Английский

Процитировано

0