Erectile Dysfunction and Oxidative Stress: A Narrative Review DOI Open Access

Dake Zhu,

Quan Minh Pham, Chunlin Wang

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 3073 - 3073

Опубликована: Март 27, 2025

Erectile dysfunction (ED) is a prevalent condition affecting male sexual health, characterized by the inability to achieve or maintain satisfactory erections. ED has multifactorial pathogenesis in which psychological, hormonal, neurologic, cardiovascular, and lifestyle factors all contribute progressive decline of erectile function. A critical underlying mechanism involves oxidative stress (OS), an imbalance between reactive oxygen species (ROS) production antioxidant defenses, disrupts endothelial function, reduces nitric oxide (NO) bioavailability, contributes vascular dysfunction. This narrative review explores interplay OS ED, focusing on roles ROS sources such as NADPH oxidase, xanthine uncoupled synthase, mitochondrial It examines impact chronic conditions like hypertension, diabetes mellitus, hyperlipidemia, hypogonadism, smoking obesity, exacerbate through systemic effects. Emerging research underscores potential therapies interventions restore redox balance, improve mitigate ED's progression. also highlights gaps understanding molecular pathways linking emphasizing need for further develop targeted therapeutic strategies.

Язык: Английский

Erectile Dysfunction and Oxidative Stress: A Narrative Review DOI Open Access

Dake Zhu,

Quan Minh Pham, Chunlin Wang

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 3073 - 3073

Опубликована: Март 27, 2025

Erectile dysfunction (ED) is a prevalent condition affecting male sexual health, characterized by the inability to achieve or maintain satisfactory erections. ED has multifactorial pathogenesis in which psychological, hormonal, neurologic, cardiovascular, and lifestyle factors all contribute progressive decline of erectile function. A critical underlying mechanism involves oxidative stress (OS), an imbalance between reactive oxygen species (ROS) production antioxidant defenses, disrupts endothelial function, reduces nitric oxide (NO) bioavailability, contributes vascular dysfunction. This narrative review explores interplay OS ED, focusing on roles ROS sources such as NADPH oxidase, xanthine uncoupled synthase, mitochondrial It examines impact chronic conditions like hypertension, diabetes mellitus, hyperlipidemia, hypogonadism, smoking obesity, exacerbate through systemic effects. Emerging research underscores potential therapies interventions restore redox balance, improve mitigate ED's progression. also highlights gaps understanding molecular pathways linking emphasizing need for further develop targeted therapeutic strategies.

Язык: Английский

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