Causal relationship between gut microbiota and ageing: A multi-omics Mendelian randomization study

Archives of Gerontology and Geriatrics, Год журнала: 2025, Номер 131, С. 105765 - 105765

Опубликована: Янв. 20, 2025

Язык: Английский

---

Akkermansia muciniphila-derived extracellular vesicles mitigate smoking-induced prostate inflammation and fibrosis

International Immunopharmacology, Год журнала: 2025, Номер 149, С. 114195 - 114195

Опубликована: Фев. 3, 2025

Язык: Английский

---

Camel Milk Protein Ameliorates Ulcerative Colitis by Modulating Gut Microbiota and Amino Acid Metabolism

Nutrients, Год журнала: 2025, Номер 17(5), С. 780 - 780

Опубликована: Фев. 24, 2025

The protective effects of the milk fat globule membrane (MFGM) in alleviating inflammation have been reported. However, limited attention has paid to key fraction protein (MFGMP). This study investigated camel MFGMP against dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) mice. results revealed that administering 50 mg/kg significantly alleviated colonic inflammation, as evidenced by a marked decrease IL-6, IL-1β, and TNF-α levels, along with pathological damage DSS-induced mice UC. supplementation partially regulated gut microbiota dysbiosis UC increasing α-diversity relative abundance beneficial bacteria, such Lactobacillus, while decreasing Akkermansia. Additionally, treatment exhibited significant regulatory on metabolites, particularly amino acid metabolism, feces. Specifically, this restored L-valine normal physiological levels increased concentrations L-leucine, L-lysine, L-tyrosine nearly twice their baseline whereas concentration L-tryptophan threefold. These upregulated acids were negatively correlated pro-inflammatory cytokines positively anti-inflammatory cytokine IL-10, indicated Spearman's correlation analysis. Furthermore, reduction mRNA expression WNT-1, β-catenin, Cyclin D1 suggests exerts positive effect via Wnt/β-catenin pathway. findings indicate modulating intestinal metabolism mice, potential implications for treating inflammatory diseases.

Язык: Английский

---

AGING THROUGH THE LENS OF THE GUT MICROBIOME: CHALLENGES AND THERAPEUTIC OPPORTUNITIES

Archives of Gerontology and Geriatrics Plus, Год журнала: 2025, Номер unknown, С. 100142 - 100142

Опубликована: Март 1, 2025

Язык: Английский

---

Oral Targeted MXenzyme – Armed Probiotic Regulates Intestinal Redox and Microbiota Homeostasis to Synergistically Ameliorate Ulcerative Colitis

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 16, 2025

Abstract Ulcerative colitis (UC) leads to complex alterations in the intestinal microenvironment, with gut microbiota dysbiosis and excessive reactive oxygen species (ROS) being major drivers. Previously, microecological preparations have been used restore homeostasis demonstrated considerable potential; however, efficacy is hindered due hostile environment gastrointestinal tract high ROS levels at lesion sites. Accordingly, a multienzyme mimicking vanadium carbide (V2C) MXenzyme armored colon‐colonizing Akkermansia muciniphila (Akk) probiotic designed synchronously alleviate inflammation regulate microbiota. V2C induced on boron hydroxyl groups coated onto via boronic acid vicinal‐diol‐based click reactions called Akk@V2C. Akk@V2C targets UC lesional sites Akk colonizing capabilities electrostatic interactions. effectively scavenges enhances colonialization mouse model colon tissue biopsies from patients UC. Furthermore, exhibits notable curative effects by alleviating inflammation, reprogramming macrophage polarization, regulating homeostasis, thus promoting short chain fatty production restoring barriers. Moreover, this approach exerts negligible impact bacterial viability has shown potential other probiotics. Collectively, given its flexibility favorable biocompatibility, promising for biomaterial delivery biomedical applications.

Язык: Английский

---

Electroacupuncture modulates the gut-brain axis via the PI3K/Akt pathway to improve feeding behavior, body weight, glucolipid metabolism, and reduce insulin resistance in T2DM rats

Diabetology & Metabolic Syndrome, Год журнала: 2025, Номер 17(1)

Опубликована: Апрель 9, 2025

Язык: Английский

---

Baseline abundance of Akkermansia muciniphila and Bacteroides acidifaciens in a healthy state predicts inflammation associated tumorigenesis in the AOM/DSS mouse model

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Апрель 10, 2025

Numerous studies demonstrate that intestinal microbiota contribute to colorectal cancer (CRC), which is often associated with dysbiosis. Most of the data were obtained from on CRC patients, making it challenging determine whether alterations in are a consequence pathology or they actively drive its progression. Several using laboratory animals suggest gut may be involved both onset and progression CRC. In present study we utilized azoxymethane-dextran sulfate sodium (AOM/DSS) mouse model investigate contribution healthy-state inflammation-associated tumorigenesis. Two cohorts C57BL/6 mice harboring different demonstrated susceptibility AOM/DSS treatment. Sequencing 16S rRNA bacterial DNA fecal samples revealed Akkermansia muciniphila Bacteroides acidifaciens as marker features (before administration), showed strong positive correlation tumor incidence. Moreover, abundance these markers, considered beneficial bacteria, was strongly positively correlated sulfate-reducing bacteria Desulfovibrio fairfieldensis identified chronic colitis-associated microbiota. Furthermore, abundances features, outcome, expression interferon gamma nitric oxide synthase 2 genes colon tissue during early stage DSS-induced inflammation. contrast multiple demonstrating anti-inflammatory properties A. B. acidifaciens, our results point out their potential adverse effect under specific conditions genotoxicity inflammation intestine. Taken together, findings complex, context-dependent role commensal dysbiosis

Язык: Английский

---

Recent Advances in Gut Microbiota in Psoriatic Arthritis

Nutrients, Год журнала: 2025, Номер 17(8), С. 1323 - 1323

Опубликована: Апрель 11, 2025

Psoriatic arthritis (PsA) is a chronic inflammatory disease characterized by joint inflammation and skin lesions. Recent research has underscored the critical role of gut microbiota—comprising bacteria, fungi, viruses, archaea—in pathogenesis progression PsA. This narrative review synthesizes latest findings on influence microbiota PsA, focusing mechanisms such as immune modulation, microbial dysbiosis, gut-joint axis, its impact treatment. Advances in high-throughput sequencing metagenomics have revealed distinct profiles associated with Studies show that individuals PsA unique composition, differing significantly from healthy controls. Alterations abundance specific bacterial taxa, including decrease beneficial bacteria an increase potentially pathogenic microbes, contribute to systemic affecting intestinal barrier promoting responses. explores various factors age, hygiene, comorbidities, medication use. Additionally, it highlights diet, probiotics, fecal transplantation promising strategies modulate alleviate symptoms. The gut-skin-joint axis concept illustrates how influences not only gastrointestinal health but also inflammation. Understanding complex interplay between could lead novel, microbiome-based therapeutic approaches. These insights offer hope for improved patient outcomes through targeted manipulation microbiota, enhancing both diagnosis treatment

Язык: Английский

---

Bibliometric analysis of research trends and prospective directions of Akkermansia muciniphila from 2010 to 2024

Frontiers in Microbiology, Год журнала: 2025, Номер 16

Опубликована: Апрель 16, 2025

Background Akkermansia muciniphila ( A. ) is an emerging probiotic with potential impact on human health, and there a growing interest in this area, but overall analysis of research trends lacking. This study conducted detailed bibliometric visualization to examine the current status, hotspots, trends, aiming inform future directions. Methods utilized Web Science database search from 2010 2024. Bibliometric was using CiteSpace VOSviewer software generate yearly publication contributions by countries, institutions, distinguished researchers, as well key themes influential researches. aimed visualize explore literature over past 15 years, guiding researches identifying gaps field intestinal flora . Results We searched total 4,423 related publications. Wei Chen, Willem de Vos Patrice D. Cani are primary contributors ‘s research. The top contributing countries institutions China, United States, South Korea, Spain, Italy, centers such Chinese Academy Sciences, Zhejiang University, University Copenhagen, Helsinki being main contributors. Current hotspots focus molecular biology , its role barrier maintenance, immune response, for regulating treating digestive metabolic diseases, cancer, fatty liver disease, inflammatory bowel etc., through bile acid metabolism, extracellular vesicles, insulin resistance. Conclusion Our synthesizes various disease areas suggests enhancing collaboration among authors advance —related clinical basic research, efficacy variety diseases effects commonly used medications fill field, provide valid evidence development novel supplement.

Язык: Английский

---

The Roles of Flavonoids in the Treatment of Inflammatory Bowel Disease and Extraintestinal manifestations : A Review

Food Bioscience, Год журнала: 2024, Номер 62, С. 105431 - 105431

Опубликована: Ноя. 8, 2024

Язык: Английский

---